Comparison of Two Autogenous Bone and Xenograft Ratios for Horizontal Ridge Augmentation

NCT07865624 | Not Yet Recruiting

• 1 other identifier: PER 6-3-1 GBR
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

This pilot randomized controlled clinical study will evaluate horizontal bone gain in patients with deficient alveolar ridges requiring horizontal ridge augmentation. The study will compare two different ratios of autogenous bone and xenograft used for bone augmentation. Participants will be randomly assigned to receive either a 50:50 mixture of autogenous bone and xenograft or a 75:25 mixture of autogenous bone and xenograft. Bone augmentation will be performed using the sausage technique with a collagen membrane. Changes in horizontal ridge dimensions will be evaluated radiographically using cone-beam computed tomography (CBCT) before treatment and during follow-up. The primary outcome will be horizontal bone gain at 6 months after augmentation.

Conditions

Horizontal Alveolar Ridge Deficiency

Keywords

Horizontal Ridge Augmentation , Autogenous Bone , Xenograft, Sausage Technique

Outcome Measures

Primary Outcomes (1)

• Radiographic Horizontal bone gain

  Horizontal bone gain will be calculated as the difference in ridge width between the baseline and 6-month measurements

  6 months

Secondary Outcomes (10)

• Clinical Horizontal Bone Gain

  6 months after augmentation

• Vertical Bone Gain

  Baseline to 6 months after augmentation

• Histomorphometric Bone Quality

  6 months after augmentation

• Soft Tissue Thickness

  Baseline and 3 and 6 months after augmentation

• Keratinized Tissue Width

  Baseline and 3 and 6 months after augmentation

Study Arms (2)

50:50 Autogenous Bone-Xenograft

EXPERIMENTAL

Participants will receive horizontal alveolar ridge augmentation using a 50:50 mixture of autogenous bone and xenograft, covered with a collagen membrane using the sausage technique.

Procedure: 50:50 Autogenous Bone-Xenograft

75:25 Autogenous Bone-Xenograft

EXPERIMENTAL

Participants will receive horizontal alveolar ridge augmentation using a 75:25 mixture of autogenous bone and xenograft, covered with a collagen membrane using the sausage technique.

Procedure: 75:25 Autogenous Bone-Xenograft

Interventions

50:50 Autogenous Bone-Xenograft PROCEDURE

Horizontal alveolar ridge augmentation using a 50:50 mixture of autogenous bone and xenograft with a collagen membrane using the sausage technique

50:50 Autogenous Bone-Xenograft

75:25 Autogenous Bone-Xenograft PROCEDURE

Horizontal alveolar ridge augmentation using a 75:25 mixture of autogenous bone and xenograft with a collagen membrane using the sausage technique.

75:25 Autogenous Bone-Xenograft

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 20 to 70 years.
• Patients with multiple missing mandibular posterior teeth (2 or more).
• Patients with compromised bone width in the posterior mandible (≤4 mm) and adequate bone height (not less than 9 mm).
• Patients with healthy systemic condition.
• Adequate inter-arch space for placement of the implant prosthetic part (8-12 mm).
• Good oral hygiene.
• Cooperative patients who are willing to commit to 6 months of follow-up.

You may not qualify if:

• Smokers.
• Pathological lesions (abscess, cyst, or acute infection) at the defect site.
• Pregnant females.
• Uncontrolled diabetic patients.
• Patients taking medications or receiving treatments that may interfere with healing, including corticosteroids, bisphosphonates, chemotherapy, or radiotherapy.

Sponsors & Collaborators

• Eslam hisham mohamed: lead
• Geistlich Pharma AG: collaborator

Study Officials

• Eslam Hisham Mohamed, B.Sc.

  Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Eslam Hisham Mohamed, B.Sc.

CONTACT

+201117182392; eslam.younes@dentistry.cu.edu.eg

Hani elnahass, Prof.Dr.

CONTACT

+20 10 00252603; hani.elnahass@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The radiographic outcomes will be assessed by an outcomes assessor who is blinded to the treatment group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Master's Student

Model Details: Participants will be randomly allocated in a 1:1 ratio to two parallel treatment arms comparing different ratios of autogenous bone and xenograft for horizontal alveolar ridge augmentation.

Study Record Dates

• First Submitted: October 3, 2026
• First Posted: October 8, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: October 8, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share