Neuropathic Pain Severity and Its Association With Radiological Findings in Lumbar Spinal Stenosis

NCT07855445 | Not Yet Recruiting

• 1 other identifier: 09.2026.26.0532
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional observational study aims to evaluate neuropathic pain severity in patients with lumbar spinal stenosis (LSS) and to investigate its association with radiological findings. Neuropathic pain will be evaluated using the Neuropathic Pain Symptom Inventory (NPSI). Pain intensity, neuropathic pain characteristics, functional status, walking capacity, and psychological symptoms will also be assessed. The relationships between NPSI scores and clinical, functional, psychological, and radiological parameters will be investigated.

Conditions

Spinal Stenosis Lumbar; Neuropathic Pain

Keywords

Neuropathic pain; Spinal stenosis

Outcome Measures

Primary Outcomes (1)

• Neuropathic Pain Symptom Inventory Total Intensity Score

  Neuropathic pain symptom intensity will be assessed using the Neuropathic Pain Symptom Inventory (NPSI). The total intensity score is calculated as the sum of 10 symptom descriptor scores and ranges from 0 to 100, with higher scores indicating greater neuropathic pain symptom intensity.

  Single assessment at baseline

Secondary Outcomes (3)

• Association Between Neuropathic Pain Severity and Radiological Severity

  Single assessment at baseline

• Association Between Neuropathic Pain Severity and Clinical Pain Intensity

  Single assessment at baseline

• Association Between Neuropathic Pain Severity and Functional Status

  Single assessment at baseline

Study Arms (1)

Patients with Lumbar Spinal Stenosis

Patients diagnosed with lumbar spinal stenosis based on clinical and magnetic resonance imaging (MRI) findings. Participants will undergo a single cross-sectional assessment including neuropathic pain symptoms, pain intensity, functional status, walking capacity, psychological symptoms, and radiological severity.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with clinically and radiologically confirmed lumbar spinal stenosis who present with low back and/or leg pain or symptoms of neurogenic claudication.

You may qualify if:

• Age ≥18 years.
• Diagnosis of lumbar spinal stenosis based on clinical evaluation and lumbar magnetic resonance imaging findings.
• Presence of low back and/or leg pain or symptoms of neurogenic claudication.
• Sufficient cognitive ability to understand and complete the study questionnaires.

You may not qualify if:

• Presence of diabetic neuropathy, polyneuropathy, peripheral nerve entrapment neuropathy, or other causes of neuropathic pain.
• Acute symptomatic lumbar disc herniation considered to be the primary cause of radicular symptoms.
• Active malignancy or a history of spinal metastasis.
• History of major lumbar spine surgery, such as lumbar fusion.
• Severe psychiatric disorder or cognitive impairment that prevents reliable completion of the study questionnaires.

Sponsors & Collaborators

• Marmara University: lead

Study Sites (1)

Marmara University Pendik Training and Research Hospital

Istanbul, Istanbul, 34899, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Neuralgia; Spinal Stenosis

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases

Central Study Contacts

Nurbanu Hindioglu Dogan

CONTACT

+90 216 625 45 45; nurbanuhindioglu@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 28, 2026
• First Posted: October 2, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: October 2, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)