Persistent Pain and Its Impact on Daily Life After Lung Surgery

NCT07853456 | Not Yet Recruiting

• 1 other identifier: THOR-PAIN-2026-002
• Study Type: observational
• Target: 350
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will examine how pain changes over the first six months after lung surgery and how it affects daily life. It will include adults scheduled for surgery to remove part or all of a lung. The main questions are:

• How does pain change from the early days after surgery to three and six months afterward?
• Which factors before surgery and during early recovery are associated with persistent pain?
• How does pain affect walking, coughing, sleep, mood, and everyday activities? Participants will complete questionnaires before surgery, during their hospital stay, at discharge, and at three and six months after surgery. These questionnaires will assess pain, its effects on daily life, sleep, and emotional well-being. Follow-up after discharge will be conducted by telephone or electronic questionnaires. Researchers will also collect information from medical records about the type of surgery, surgical incisions, anesthesia, pain relief treatments, and chest drains. This is an observational study. The research team will not assign pain treatments or change usual care. The findings may help identify patients who need additional pain assessment and support during recovery.

Conditions

Chronic Postsurgical Pain; Acute Postoperative Pain; Pain-Related Functional Interference

Outcome Measures

Primary Outcomes (1)

• Incidence of Chronic Postsurgical Pain at 3 Months After Lung Resection

  3 months after surgery

Interventions

Longitudinal Assessment of Pain and Pain-Related Functional Interference OTHER

Participants will undergo questionnaire-based assessments before lung resection, during the postoperative hospital stay, at discharge, and at 3 and 6 months after surgery. Assessments will cover pre-existing pain, postoperative pain intensity and location, and pain-related interference with daily activities, sleep, and emotional well-being. Post-discharge assessments will be conducted by telephone or electronic questionnaires. Information on surgical procedures, anesthesia, analgesic treatments, and chest drains will be collected from medical records. These assessments are conducted for observational research only. No analgesic treatment is assigned by the study, and all participants receive routine clinical care.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18 years or older scheduled for elective lung resection at Aerospace Center Hospital, Beijing, China, will be consecutively recruited during preoperative assessment. Patients undergoing surgery for benign or malignant lung conditions through video-assisted, robot-assisted, or open approaches will be eligible. Patients with pre-existing chronic pain and those who have received neoadjuvant treatment may participate. Baseline pain and treatment history will be recorded. Participants will be followed through 6 months after surgery to assess pain persistence and pain-related interference with daily life.

You may qualify if:

• \- Age 18 years or older.
• Scheduled for elective lung resection, including wedge resection, segmentectomy, lobectomy, bilobectomy, or pneumonectomy, through a video-assisted, robot-assisted, or open surgical approach.
• Able to understand and answer the study questionnaires in Chinese, independently or with standardized assistance from research staff.
• Willing to complete assessments before surgery, during hospitalization, at discharge, and at 3 and 6 months after surgery.
• Provides written informed consent.

You may not qualify if:

• Emergency surgery.
• Planned concomitant major surgery involving another organ, such as esophagectomy or cardiac surgery.
• Cognitive impairment or another condition that prevents informed consent or reliable self-reported questionnaire responses despite assistance.

Sponsors & Collaborators

• Aerospace Center Hospital: lead

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2026
• First Posted: October 1, 2026
• Study Start (Estimated): October 10, 2026
• Primary Completion (Estimated): March 10, 2027
• Study Completion (Estimated): April 10, 2027
• Last Updated: October 1, 2026

Record last verified: 2026-09