Prevalence and Risk Factors for Chronic Post-Surgical Pain Following Video-Assisted Thoracic Surgery : The EVATHO Prospective Bicentric Cohort Study.

NCT07687082 | Not Yet Recruiting

• 1 other identifier: RECHMPL 25_0555
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life. Although the widespread adoption of video-assisted thoracic surgery (VATS) has reduced surgical trauma and improved postoperative recovery, a substantial proportion of patients still develop persistent pain. The EVATHO study is a multicenter prospective observational cohort designed to determine the prevalence of CPSP three months after VATS and to identify perioperative factors associated with its development. Adult patients undergoing thoracic surgery by VATS at Montpellier and Nice University Hospitals will be prospectively enrolled. Pain intensity, neuropathic pain characteristics, anxiety, depression, quality of life, and analgesic consumption will be assessed using validated questionnaires during the perioperative period and at 1 and 3 months after surgery. The results of this study may help identify patients at increased risk of CPSP and improve perioperative pain management strategies following thoracic surgery.

Conditions

Chronic Post-surgical Pain; Neuropathic Pain; Thoracic Surgical Procedures; Postoperative Pain After Thoracic Surgery

Outcome Measures

Primary Outcomes (1)

• Number of participants with chronic post-surgical pain

  Chronic post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 3-month postoperative follow-up.

  3 months after surgery.

Secondary Outcomes (9)

• Postoperative pain at 1 month after VATS

  1 month after thoracic surgery

• Visual Analogue Scale (VAS) pain score

  Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.

• Cumulative postoperative opioid consumption.

  Postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.

• Douleur Neuropathie 4 (DN4) score

  Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.

• Hospitalier Anxiety and depression Scale (HADS) anxiety score

  Preoperative assessment, 1 month, and 3 months after surgery.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing video-assisted thoracic surgery (VATS) for pulmonary resection, pleural procedures, chest wall surgery, or lung biopsy at Montpellier and Nice University Hospitals.

You may qualify if:

• Adult patients undergoing video-assisted thoracic surgery (VATS) for thoracic surgery

You may not qualify if:

• Age \<18 years
• Adults under legal protection or unable to provide informed non-opposition
• Patients unable to understand or complete the study questionnaires
• Patients not affiliated with a French health insurance scheme.
• Adults under legal protection, including judicial safeguard, guardianship, or curatorship.
• Pregnant or breastfeeding women.

Sponsors & Collaborators

• University Hospital, Montpellier: lead

MeSH Terms

Conditions

Pain, Postoperative; Neuralgia

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases

Central Study Contacts

Benjamin Bourdois, MD

CONTACT

+33467335958; b-bourdois@chu-montpellier.fr

Sophie Bringuier, MD

CONTACT

+33467335958

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 21, 2026
• First Posted: July 7, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): April 1, 2028
• Study Completion (Estimated): August 1, 2028
• Last Updated: July 7, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share