Minicrush Versus Culotte Stenting in Complex Coronary Bifurcation Lesions:The Multicenter T-REX II Registry

NCT07849335 | Enrolling By Invitation DMC

• 1 other identifier: 007/2026
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Percutaneous coronary intervention (PCI) of complex coronary bifurcation lesions frequently requires an upfront two-stent strategy. While the double kissing crush technique has been extensively studied, limited contemporary data are available comparing alternative two-stent approaches, particularly Minicrush and T-stenting and Culotte, in complex bifurcation anatomy. This study aimed to compare procedural characteristics and long-term clinical outcomes of Minicrush versus Culotte stenting techniques in patients undergoing PCI for complex coronary bifurcation lesions.

Conditions

Coronary Artery Disease (CAD); Percutaneous Coronary Intervention (PCI); Bifurcation Coronary Artery Disease

Keywords

Minicrush; Culotte; PCI; Bifurcation lesions

Outcome Measures

Primary Outcomes (1)

• Target Lesion Failure (TLF)

  Composite of cardiac death, Target Vessel Myocardial Infarction and Target Lesion Revascularization

  From the enrollment to the end of the study at 5 years

Secondary Outcomes (1)

• Major Adverse Cardiovascular Events (MACE)

  From the enrollment to the endif the treatment at 5 years

Study Arms (1)

Minicrush Patients

Culotte Patients

Procedure: Percutaneous Coronary Intervention with Minicrush

Interventions

Percutaneous Coronary Intervention with Minicrush PROCEDURE

The Minicrush and Culotte techniques were performed as upfront two-stent strategies according to standard protocols focusing on minimal side-branch stent protrusion and carina reconstruction, respectively.

Minicrush Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This cohort study included all patients with complex coronary bifurcation lesions who received intentional two-stent treatment with the Minicrush or Culotte techniques

You may qualify if:

• Patients with complex coronary bifurcation lesions according to DEFINITION criteria

You may not qualify if:

• \<18 years
• Treatment with other techniques
• Non-complex coronary bifurcation lesions

Sponsors & Collaborators

• San Luigi Gonzaga Hospital: lead

Study Sites (1)

Rivoli Hospital

Rivoli, Turin, 10098, Italy

Location

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

Percutaneous Coronary Intervention

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Endovascular Procedures; Vascular Surgical Procedures; Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MedicalDoctor

Study Record Dates

• First Submitted: September 24, 2026
• First Posted: September 30, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: September 30, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)