Gait Pattern and Its Relation to Cognition and VEP in Multiple Sclerosis

NCT07847086 | Not Yet Recruiting

• 1 other identifier: MS-Gait-Assiut-2026
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

This cross-sectional study aims to assess the pattern of gait in patients with multiple sclerosis and to evaluate its relation to cognitive function, visual evoked potentials, and radiological findings.

Conditions

Gait Disorders, Neurologic; Multiple Sclerosis

Keywords

Visual evoked potentials; Multiple sclerosis; Gait analysis; Cognition; Assiut

Outcome Measures

Primary Outcomes (1)

• Mean gait velocity

  Mean gait velocity in meters per second measured by quantitative spatiotemporal gait analysis.

  Baseline

Secondary Outcomes (5)

• Mean cadence

  Baseline

• Mean stride length

  Baseline

• Mean MoCA score

  Baseline

• Mean P100 latency

  Baseline

• Mean EDSS score

  Baseline

Study Arms (1)

Single cohort: Multiple Sclerosis Patients

Patients with confirmed multiple sclerosis who will undergo gait analysis, cognitive testing, visual evoked potential assessment, and MRI review in a single visit.

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients with multiple sclerosis attending the Neurology Department outpatient clinic and gait laboratory at Assiut University.

You may qualify if:

• \- Age 18 to 55 years
• Confirmed diagnosis of multiple sclerosis according to the revised McDonald criteria
• Clinically stable (no relapse or steroid treatment within 4 weeks)
• Able to walk independently with or without a single assistive device
• Written informed consent

You may not qualify if:

• \- Other neurological, orthopedic, visual, or vestibular conditions affecting gait
• Severe cognitive impairment precluding valid testing
• Pregnancy
• MRI contraindications
• Ocular disease unrelated to multiple sclerosis

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Multiple Sclerosis; Gait Disorders, Neurologic

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Tarek A Rageh, prof

  Neuropsychiatry Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Manar A Ali, Resident

CONTACT

01091423914; manarmoataz2000@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Department of Neuropsychiatry

Study Record Dates

• First Submitted: September 23, 2026
• First Posted: September 29, 2026
• Study Start: September 26, 2026
• Primary Completion (Estimated): September 26, 2027
• Study Completion (Estimated): March 1, 2028
• Last Updated: October 1, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share