Oct-A and Perimetry in Multiple Sclerosis

NCT07175324 | Not Yet Recruiting

• 1 other identifier: OctA in Multiple sclerosis
• Study Type: observational
• Target: 32
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to assess retinal vascular density using OCT-A and correlate these parameters with visual field changes in MS patients with and without a history of ON

Conditions

Multiple Sclerosis

Keywords

MS; OctA

Outcome Measures

Primary Outcomes (1)

• 1-To evaluate the correlation between OCTA-derived microvascular metrics {Structural measure} and visual field defects{Functional measure} in patients with multiple sclerosis (MS)

  The aim of this work is to investigate the correlation between visual field parameters and optical coherence tomography angiography (OCT-A) findings in patients with multiple sclerosis (MS). MS is a chronic autoimmune demyelinating disease that frequently involves the visual pathway, often presenting with optic neuritis (ON) and subsequent neurodegeneration. OCT-A, a non-invasive imaging modality, enables detailed visualization and quantification of retinal microvasculature, particularly the superficial and deep capillary plexuses, which supply the retinal ganglion cells and nerve fiber layers. Previous studies have demonstrated reduced retinal vessel density and thinning of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in MS patients, reflecting neuro-axonal damage and microvascular impairment. However, the correlation between these structural and vascular changes and functional visual outcomes, such as visual field loss, remains to be fully elucidated.

  baseline

Study Arms (2)

patients with multiple sclerosis

Device: optical coherence tomography angiography; Device: Visual Field Perimetry

healthy control

Device: optical coherence tomography angiography; Device: Visual Field Perimetry

Interventions

optical coherence tomography angiography DEVICE

correlation between OctA and Visual field changes in Multiple Sclerosis

healthy control; patients with multiple sclerosis

Visual Field Perimetry DEVICE

Correlation between OctA and Visual field changes in Multiple sclerosis

healthy control; patients with multiple sclerosis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with multiple sclerosis and healthy control group in Assiut

You may qualify if:

• Diagnosis of relapsing-remitting multiple sclerosis (RR-MS) or other MS subtypes confirmed by established neurological criteria. .Ability to undergo OCTA imaging and visual field testing. .Visual acuity sufficient to perform reliable visual field testing.
• Absence of other ocular diseases affecting the retina or optic nerve (e.g., diabetic retinopathy, glaucoma)

You may not qualify if:

• History of ocular diseases unrelated to MS that could confound OCTA or visual field results.
• Recent optic neuritis episode within a defined period (often 3-6 months) to avoid acute inflammation effects.
• Media opacities preventing quality OCTA imaging. .Systemic diseases that may affect retinal vasculature (e.g., uncontrolled hypertension, diabetes).
• Poor cooperation or inability to complete visual field testing reliably

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Mancino, R., Martucci, A., Di Costanzo, A., et al. (2021).Optical coherence tomography and optical coherence tomography angiography findings in multiple sclerosis patientshttps://www.tandfonline.com/doi/full/10.1080/01658107.2021.1963787

  BACKGROUND

• Liu J, Song S, Gu X, Li H, Yu X. Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis. Front Neurosci. 2023 Jan 13;16:1121899. doi: 10.3389/fnins.2022.1121899. eCollection 2022.

  PMID: 36711144 BACKGROUND

• Farci R, Carta A, Cocco E, Frau J, Fossarello M, Diaz G. Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study. PLoS One. 2020 Jul 23;15(7):e0236090. doi: 10.1371/journal.pone.0236090. eCollection 2020.

  PMID: 32702050 BACKGROUND

• Mohammadi S, Gouravani M, Salehi MA, Arevalo JF, Galetta SL, Harandi H, Frohman EM, Frohman TC, Saidha S, Sattarnezhad N, Paul F. Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis. J Neuroinflammation. 2023 Mar 27;20(1):85. doi: 10.1186/s12974-023-02763-4.

  PMID: 36973708 BACKGROUND

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

Visual Field Tests

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Vision Tests; Diagnostic Techniques, Ophthalmological; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Omar Gamal Nouby, resident doctor

CONTACT

+0201124142020; omar.17289573@med.aun.edu.eg

Momen Ahmad Aly, Lecturer

CONTACT

+0201003821818; momenkhodair@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: September 3, 2025
• First Posted: September 16, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: September 16, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share