NCT07845838

Brief Summary

A six week patient study that intends to prove that training helps improve the life of people with osteoatritis of the knee. It looks at pain and function in daily life and markers in the blood that show stress at a cell level.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable knee-osteoarthritis

Timeline
8mo left

Started May 2025

Typical duration for not_applicable knee-osteoarthritis

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress68%
May 2025Jun 2027

Study Start

First participant enrolled

May 5, 2025

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

September 21, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 29, 2026

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

September 29, 2026

Status Verified

September 1, 2026

Enrollment Period

2.1 years

First QC Date

September 21, 2026

Last Update Submit

September 21, 2026

Conditions

Knee OsteoarthritisOxidative Stress

Outcome Measures

Primary Outcomes (3)

  • NRPS Pain score

    numeric pain rating scale

    6 weeks

  • PSPF

    Patient Specific Functional Scale

    6 weeks

  • oxidative stress bloodmarkers

    d-Roms fast test

    6 weeks

Study Arms (2)

supervised training

EXPERIMENTAL

the patient will recieve 6 weeks of 2 supevised trainings per week as an outpatient

Other: supervised training

walking

ACTIVE COMPARATOR

the patient will walk 6000 steps per day for the duration of 6 weeks

Other: daily walking

Interventions

supervised trainingOTHER

supervised training by a trained physical therapist, focussed on strength and overall fitness

supervised training
daily walkingOTHER

walking 6000 steps per day unsupervised

walking

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • diagnosed Knee osteoartritis in one or both knees

You may not qualify if:

  • not able to walk 6000 steps
  • not able to participate in the training

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Fysiotherapie de Rozenburcht

Capelle aan den IJssel, 2902BW, Netherlands

RECRUITING

Related Links

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • Aldo Scafoglieri, Prof

    professor at VUB

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mariette boshuis-scheenstra

CONTACT

+31102847365Mariette@rozenburcht.com

boudewijn Scheenstra

CONTACT

+31102847365fysio@rozenburcht.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: randomised 2 group study
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Physical and Manual therapist

Study Record Dates

First Submitted

September 21, 2026

First Posted

September 29, 2026

Study Start

May 5, 2025

Primary Completion (Estimated)

June 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

September 29, 2026

Record last verified: 2026-09

Data Sharing

IPD Sharing
Will not share

Locations

NL(1)