Proton MRI of MSK Disorders

NCT07845708 | Recruiting

• 1 other identifier: 2024-0256
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

In this research study we want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. We will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. We also want to collect images and health information about lungs that are healthy or those in people with different kinds of lung, muscular, and bone diseases. This collection will help us in the future to better understand lung variations in health and disease.

Conditions

Muskuloskeletal Diseases; Healthy; Respiratory

Outcome Measures

Primary Outcomes (2)

• Develop, optimize, and validate of 1H MRI sequences for assessment of lung structure and function

  Structural 1H MRI parameters such as relative 1H signal intensity and radiologists interpretation will be compared to retrospective clinical images to determine viability of 1H MRI to assess lung disease.

  Through study completion, an average of 5 years

• Generate preliminary bSSFP UTE 1H MRI data in healthy individuals and individuals with thoracic musculoskeletal disorders.

  Free-breathing bSSFP UTE 1H MRI images will be compared to other conventional structural 1H MRI techniques and aspects like relative 1H signal between images will be compared.

  Through study completion, an average of 5 years

Interventions

MRI DIAGNOSTIC_TEST

This intervention uses specialized MRI sequences, UTE and bSSFP, alongside traditional MRI to capture high-resolution images of lung structure and function. These sequences are optimized for imaging pulmonary tissues and airspaces, which is not typical in standard clinical MRI protocols. The study focuses on both healthy participants and those with lung, muscular, and bone diseases to evaluate variations in lung imaging.

Eligibility Criteria

• Age: 5 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We plan to enroll about 50 subjects with diagnosed respiratory and/or musculoskeletal disease and about 50 subjects with no diagnosed respiratory or musculoskeletal disease to serve as healthy controls. Participants will be recruited from the general population without restriction to a specific location or clinic.

You may qualify if:

• Age ≥ 5 years

You may not qualify if:

• History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject.
• Pregnancy

Sponsors & Collaborators

• Laura Walkup: lead

Study Sites (1)

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

RECRUITING

Study Officials

• Laura Walkup, PhD

  Children's Hospital Medical Center, Cincinnati

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ashley Borden, MPH

CONTACT

5136360143; ashley.borden@cchmc.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 22, 2026
• First Posted: September 29, 2026
• Study Start: June 17, 2025
• Primary Completion (Estimated): June 1, 2030
• Study Completion (Estimated): June 1, 2030
• Last Updated: September 29, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)