The Establishment of Large-sample Database of "Multiple-MRI/Gene/Cognition"

NCT02144467 | Unknown DMC FDA Device

• 1 other identifier: HNU_CCBD_LargeSampleCollection
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

Aim to establish a large-sample database of "Multiple-MRI/Gene/Cognition" for healthy Chinese (sample number, 5000; age, 6-70 years). This is a fundamental but very necessary work for future researches such as development, aging, relation of gene and behavior, relation of gene and neuroimaging, relation of behavior and neuroimaging. Importantly, this work will provide a norm for researches on psychological or neurological patients. This large-sample will be shared with world-wide researchers.

Conditions

Healthy

Keywords

Multiple-MRI, Gene, Cognition

Outcome Measures

Primary Outcomes (1)

• The distribution of the amplitude of blood oxygenation level dependent(BOLD) signal in healthy subjects

  The amplitude of BOLD-functional magnetic resonance imaging(fMRI) signal is a common measure to estimate the brain activity during resting-state. We try to establish its distribution on healthy subjects, which could be a control to examine abnormal brain function in patients.

  up to 15 months

Study Arms (1)

Large-sample healthy participants

MRI scanning.

Device: MRI

Interventions

MRI DEVICE

fMRI, sMRI, ASL and DTI

Large-sample healthy participants

Eligibility Criteria

• Age: 6 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Residents of Hangzhou, China.

You may qualify if:

• Healthy Chinese
• Age: 6-70 years old
• Right handed
• No smoking or alcoholic addiction

You may not qualify if:

• Psychological or neurological patients
• Hypertension or cardiopathy patients
• Pregnant woman
• Take medicine or drink tea/coffee before scanning-

Sponsors & Collaborators

• Hangzhou Normal University: lead

Study Sites (1)

Hangzhou Normal University,Center for Cognition and Brain Disorder

Hangzhou, Zhejiang, 310010, China

RECRUITING

Related Publications (1)

• Jing Y, Zhao N, Deng XP, Feng ZJ, Huang GF, Meng M, Zang YF, Wang J. Pregenual or subgenual anterior cingulate cortex as potential effective region for brain stimulation of depression. Brain Behav. 2020 Apr;10(4):e01591. doi: 10.1002/brb3.1591. Epub 2020 Mar 8.

  PMID: 32147973 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Peripheral Venous Blood

Study Officials

• Yu-Feng ZANG, M.D.

  Hangzhou Normal University, Center for Cognition and Brain Disorder

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jue Wang, PHD

CONTACT

juefirst@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: deputy director

Study Record Dates

• First Submitted: May 14, 2014
• First Posted: May 22, 2014
• Study Start: May 8, 2014
• Primary Completion: August 2, 2022
• Study Completion: August 2, 2022
• Last Updated: August 3, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)