Serum EBI-3 Protein Levels in Behçet's Disease

NCT07845162 | Not Yet Recruiting

• 1 other identifier: EBI3-Behcet-Assiut-2026
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

This cross-sectional study aims to evaluate serum Epstein-Barr virus-induced gene 3 (EBI-3) protein levels in patients with Behçet's disease compared with healthy controls.

Conditions

Behçet Disease

Keywords

Behçet's disease; EBI-3 Serum; biomarker; Assiut

Outcome Measures

Primary Outcomes (1)

• Mean serum EBI-3 protein level

  Mean serum Epstein-Barr virus-induced gene 3 (EBI-3) protein concentration measured by ELISA in patients with Behçet's disease compared with healthy controls.

  Baseline

Secondary Outcomes (4)

• Serum EBI-3 level according to disease activity

  Baseline

• Serum EBI-3 level in patients with vascular involvement

  Baseline

• Serum EBI-3 level in patients with ocular involvement

  Baseline

• Serum EBI-3 level in patients with neurological involvement

  Baseline

Study Arms (2)

Behçet's Disease

Patients diagnosed with Behçet's disease according to the International Criteria for Behçet's Disease.

Healthy Controls

Age-matched healthy individuals without autoimmune or inflammatory diseases.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with Behçet's disease attending the Physical Medicine, Rheumatology and Rehabilitation Department at Assiut University Hospitals, and healthy controls.

You may qualify if:

• \- Age 18 years or older
• Diagnosis of Behçet's disease according to the International Criteria for Behçet's Disease (cases)
• Healthy individuals without autoimmune or inflammatory diseases (controls)
• Written informed consent

You may not qualify if:

• \- Other autoimmune disorders (RA, SLE, psoriatic arthritis, ankylosing spondylitis)
• Acute or chronic infection
• Malignancy or history of malignancy
• Chronic liver disease or advanced chronic kidney disease
• Pregnancy or lactation
• Vasculitis caused by diseases other than Behçet's disease

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Behcet Syndrome

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Uveitis, Anterior; Panuveitis; Uveitis; Uveal Diseases; Eye Diseases; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Hereditary Autoinflammatory Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases, Genetic; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Vascular

Study Officials

• Gehan I Abdelraziq, prof

  Physical Medicine, Rheumatology and Rehabilitation Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Shrouk S Mohamed, Resident

CONTACT

01004638754; shrouk.18313202@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Department of Physical Medicine, Rheumatology and Rehabilitation

Study Record Dates

• First Submitted: September 22, 2026
• First Posted: September 28, 2026
• Study Start: September 26, 2026
• Primary Completion (Estimated): September 26, 2027
• Study Completion (Estimated): January 25, 2028
• Last Updated: September 28, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share