Chest Wall Deformities Beyond the Chest Wall

NCT07844382 | Completed

• 2 other identifiers: EMU-FTR-BA-02SBF00-2025-17218
• Study Type: observational
• Target: 186
• Locations: 1 country
• Sites: 1

Brief Summary

Pectus excavatum (PE) and pectus carinatum (PC) are chest wall deformities that may influence respiratory function, physical capacity, posture, and quality of life. This observational, cross-sectional study aims to provide a comprehensive and multidimensional evaluation of children with PE and PC and compare their findings with healthy controls. By examining multiple aspects of respiratory and physical function, postural characteristics, and quality of life, the study seeks to provide a broader understanding of the overall impact of these deformities.

Conditions

Pectus Carinatum; Pectus Excavatum

Keywords

Respiratory Function; Functional Capacity; Posture; Quality of Life

Outcome Measures

Primary Outcomes (4)

• Forced Vital Capacity (FVC)

  Forced vital capacity (FVC) was assessed using spirometry and expressed as a percentage of the predicted value.

  Baseline

• Forced Expiratory Volume in One Second (FEV1)

  Forced expiratory volume in one second (FEV1) was assessed using spirometry and expressed as a percentage of the predicted value.

  Baseline

• FEV1/FVC Ratio

  The FEV1/FVC ratio was assessed using spirometry and expressed as a percentage of the predicted value.

  Baseline

• Maximal Voluntary Ventilation (MVV)

  Maximal voluntary ventilation (MVV) was assessed using spirometry and expressed as a percentage of the predicted value.

  Baseline

Secondary Outcomes (12)

• Respiratory Muscle Strength

  Baseline

• Physical Activity Level

  Baseline

• Aerobic Capacity

  Baseline

• Body Composition

  Baseline

• Handgrip Strength

  Baseline

Study Arms (3)

Pectus Excavatum Group

Participants diagnosed with pectus excavatum

Pectus Carinatum

Participants diagnosed with pectus carinatum

Healthy Control Group

Age-matched healthy participants without pectus deformity

Eligibility Criteria

• Age: 10 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of individuals aged 10-18 years diagnosed with pectus excavatum or pectus carinatum at a specialized thoracic surgery clinic and age-matched healthy controls

You may qualify if:

• Individuals aged 10-18 years with pectus excavatum
• Individuals aged 10-18 years with pectus carinatum
• Healthy volunteers aged 10-18 years

You may not qualify if:

• Previous conservative or surgical treatment for pectus excavatum
• Major surgery within the previous 6 months
• Congenital or acquired cardiac disease
• Congenital or acquired pulmonary disease
• Neuromuscular or orthopedic disease
• Connective tissue disorders (Marfan syndrome, Turner syndrome, neurofibromatosis, or tuberous sclerosis)
• Diagnosed psychological or cognitive problems
• Obesity or severe underweight (BMI below the 5th percentile or above the 95th percentile)
• Hearing or visual impairment not corrected with hearing aids or glasses
• Acute infection, including an acute respiratory tract infection within the previous 2 weeks

Sponsors & Collaborators

• Eastern Mediterranean University: lead

Study Sites (1)

Pektus Klinik

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Funnel Chest; Pectus Carinatum; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Bone Diseases, Developmental; Bone Diseases; Musculoskeletal Diseases; Musculoskeletal Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cartilage Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Emine H Tüzün, PhD

  Eastern Mediterranean University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2026
• First Posted: September 28, 2026
• Study Start: November 20, 2025
• Primary Completion: August 22, 2026
• Study Completion: August 22, 2026
• Last Updated: September 28, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)