NCT07843355

Brief Summary

Children who experience severe burns may continue to have reduced muscle strength, power, balance, and physical function after their wounds have healed. Exercise is an important part of burn rehabilitation, but it is unclear which type of training provides the greatest improvement. This randomized study compared three exercise programs in children aged 10 to 17 years with burns affecting more than 30% of their total body surface area. Participants were assigned to traditional resistance training, plyometric training, or a program combining both approaches. Each group completed supervised exercise sessions three times per week for 8 weeks. Muscle strength, upper- and lower-body power, dynamic balance, and upper-limb stability were measured before and after the training period. The study aimed to determine which exercise approach was most effective for improving neuromuscular and functional performance during long-term pediatric burn rehabilitation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
78

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2025

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 10, 2025

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 10, 2026

Completed
18 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 28, 2026

Completed
24 days until next milestone

First Submitted

Initial submission to the registry

September 21, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 28, 2026

Completed
Last Updated

September 28, 2026

Status Verified

September 1, 2026

Enrollment Period

1.5 years

First QC Date

September 21, 2026

Last Update Submit

September 21, 2026

Conditions

Keywords

Resistance TrainingPlyometric TrainingMuscle StrengthNeuromuscular PerformanceDynamic BalancePhysical Function

Outcome Measures

Primary Outcomes (18)

  • Overhead Medicine Ball Throw

    Upper-body explosive power was assessed using overhead medicine ball throw. Three maximal attempts were performed with 60 seconds of rest between attempts. The longest valid throw was retained. Distance was measured in centimeters, with a greater distance indicating better performance.

    Week 0 before the intervention

  • Overhead Medicine Ball Throw

    Upper-body explosive power was assessed using overhead medicine ball throw. Three maximal attempts were performed with 60 seconds of rest between attempts. The longest valid throw was retained. Distance was measured in centimeters, with a greater distance indicating better performance.

    After Week 8

  • Standing Long Jump Distance

    Horizontal lower-body explosive power was evaluated using a two-legged standing long jump. Three maximal attempts were completed, and the longest valid jump was retained. Distance was reported in centimeters, with a greater distance indicating better performance.

    Week 0 before the intervention

  • Standing Long Jump Distance

    Horizontal lower-body explosive power was evaluated using a two-legged standing long jump. Three maximal attempts were completed, and the longest valid jump was retained. Distance was reported in centimeters, with a greater distance indicating better performance.

    After Week 8

  • Countermovement Jump Height

    Vertical lower-body explosive power was evaluated using a countermovement jump. Three valid attempts were completed, and the greatest jump height was retained. Height was reported in centimeters, with a greater height indicating better performance.

    Week 0 before the intervention

  • Countermovement Jump Height

    Vertical lower-body explosive power was evaluated using a countermovement jump. Three valid attempts were completed, and the greatest jump height was retained. Height was reported in centimeters, with a greater height indicating better performance.

    After Week 8

  • Knee Flexor Isometric Strength

    Maximal isometric strength of the knee flexors in the dominant limb was measured with a calibrated handheld dynamometer. The result was reported in kilograms.

    Week 0 before the intervention

  • Knee Flexor Isometric Strength

    Maximal isometric strength of the knee flexors in the dominant limb was measured with a calibrated handheld dynamometer. The result was reported in kilograms.

    After Week 8

  • Knee Extensor Isometric Strength

    Maximal isometric strength of the knee extensors was measured with a calibrated handheld dynamometer. The result was reported in kilograms.

    Week 0 before the intervention

  • Knee Extensor Isometric Strength

    Maximal isometric strength of the knee extensors was measured with a calibrated handheld dynamometer. The result was reported in kilograms.

    After Week 8

  • Elbow Flexor Isometric Strength

    Maximal isometric strength of the elbow flexors was measured with a calibrated handheld dynamometer. The result was reported in kilograms.

    Week 0 before the intervention

  • Elbow Flexor Isometric Strength

    Maximal isometric strength of the elbow flexors was measured with a calibrated handheld dynamometer. The result was reported in kilograms.

    After Week 8

  • Elbow Extensor Isometric Strength

    Maximal isometric strength of the elbow extensors was measured with a calibrated handheld dynamometer. The result reported in kilograms.

    Week 0 before the intervention

  • Elbow Extensor Isometric Strength

    Maximal isometric strength of the elbow extensors was measured with a calibrated handheld dynamometer. The result reported in kilograms.

    After Week 8

  • Hand Grip Strength

    Maximal grip strength of the dominant hand was assessed with a calibrated hydraulic hand dynamometer. The result was reported in kilograms.

    Week 0 before the intervention

  • Hand Grip Strength

    Maximal grip strength of the dominant hand was assessed with a calibrated hydraulic hand dynamometer. The result was reported in kilograms.

    After Week 8

  • Trunk Lift Test

    Trunk-extension performance was assessed using the Trunk Lift Test. Two maximal attempts were completed, and the greater valid distance was retained.

    Week 0 before the intervention

  • Trunk Lift Test

    Trunk-extension performance was assessed using the Trunk Lift Test. Two maximal attempts were completed, and the greater valid distance was retained.

    After Week 8

Secondary Outcomes (4)

  • Modified Closed Kinetic Chain Upper Extremity Stability Test

    Week 0 before the intervention

  • Modified Closed Kinetic Chain Upper Extremity Stability Test

    After Week 8

  • Y-Balance Test

    Week 0 before the intervention

  • Y-Balance Test

    After Week 8

Study Arms (3)

Traditional Resistance Training

EXPERIMENTAL

Participants completed a supervised traditional resistance-training program three times per week on nonconsecutive days for 8 weeks.

Other: Traditional Resistance Training

Plyometric Training

EXPERIMENTAL

Participants completed a supervised plyometric-training program three times per week on nonconsecutive days for 8 weeks.

Other: Plyometric Training

Combined Resistance and Plyometric Training

EXPERIMENTAL

Participants completed a supervised program combining traditional resistance and plyometric exercises three times per week on nonconsecutive days for 8 weeks.

Other: Combined Resistance and Plyometric Training

Interventions

Participants performed eight progressive resistance exercises targeting the upper and lower body. Sessions were held three times weekly for 8 weeks. Sessions were supervised by physical therapists and included a 10-minute warm-up and 5-minute cool-down.

Also known as: Strength Training
Traditional Resistance Training

Participants performed progressive upper- and lower-body plyometric exercises three times weekly for 8 weeks. Physical therapists supervised all sessions and emphasized safe takeoff and landing technique. Each session included a 10-minute warm-up and 5-minute cool-down.

Also known as: Power Training
Plyometric Training

Participants performed traditional resistance exercises and plyometric exercises per session, three times weekly for 8 weeks. All sessions were supervised by physical therapists and included a 10-minute warm-up and 5-minute cool-down.

Also known as: Combined Strength and Power Training
Combined Resistance and Plyometric Training

Eligibility Criteria

Age10 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Children aged 10 to 17 years.
  • History of a major thermal burn affecting more than 30% of total body surface area.
  • Time since burn injury between 0.1 and 2 years.

You may not qualify if:

  • A pre-existing or acquired neurological, musculoskeletal, cardiopulmonary, or cognitive condition that could interfere with physical performance or affect interpretation of the study outcomes.
  • Reconstructive surgery performed during the 6 months before the pre-intervention assessment.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shorook Physical Therapy Centers

Cairo, Egypt

Location

Related Publications (5)

  • Yang S, Qiu L, Xiao J, Luo C. The effects of resistance training on children with burns: a meta-analysis. Pediatr Surg Int. 2021 Oct;37(10):1323-1332. doi: 10.1007/s00383-021-04947-6. Epub 2021 Jul 30.

    PMID: 34331107BACKGROUND
  • Cambiaso-Daniel J, Rivas E, Carson JS, Hundeshagen G, Nunez Lopez O, Glover SQ, Herndon DN, Suman OE. Cardiorespiratory Capacity and Strength Remain Attenuated in Children with Severe Burn Injuries at Over 3 Years Postburn. J Pediatr. 2018 Jan;192:152-158. doi: 10.1016/j.jpeds.2017.09.015.

    PMID: 29246338BACKGROUND
  • Hardee JP, Porter C, Sidossis LS, Borsheim E, Carson JA, Herndon DN, Suman OE. Early rehabilitative exercise training in the recovery from pediatric burn. Med Sci Sports Exerc. 2014 Sep;46(9):1710-6. doi: 10.1249/MSS.0000000000000296.

    PMID: 24824900BACKGROUND
  • Palackic A, Suman OE, Porter C, Murton AJ, Crandall CG, Rivas E. Rehabilitative Exercise Training for Burn Injury. Sports Med. 2021 Dec;51(12):2469-2482. doi: 10.1007/s40279-021-01528-4. Epub 2021 Aug 2.

  • Basha MA, Aboelnour NH, Aly SM, Kamel FAH. Impact of Kinect-based virtual reality training on physical fitness and quality of life in severely burned children: A monocentric randomized controlled trial. Ann Phys Rehabil Med. 2022 Jan;65(1):101471. doi: 10.1016/j.rehab.2020.101471. Epub 2021 Nov 23.

MeSH Terms

Conditions

Burns

Interventions

Resistance TrainingPlyometric Exercise

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Ragab K Elnaggar, PhD

    Cairo University

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Participants were assigned in a 1:1:1 ratio to three parallel exercise-training groups: traditional resistance training, plyometric training, or combined resistance and plyometric training.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Physical Therapy

Study Record Dates

First Submitted

September 21, 2026

First Posted

September 28, 2026

Study Start

February 10, 2025

Primary Completion

August 10, 2026

Study Completion

August 28, 2026

Last Updated

September 28, 2026

Record last verified: 2026-09

Data Sharing

IPD Sharing
Will share

The manuscript states that study datasets may be obtained from the corresponding author following a reasonable and relevant request, subject to approval by all co-authors.

Shared Documents
STUDY PROTOCOL
Time Frame
6 months after publication
Access Criteria
relevance to the topic of the study and approval of all co-authors within 1month of receiving the request.

Locations