Myocardial Changes in Pediatric Guillain-Barré Syndrome

NCT07842705 | Not Yet Recruiting

• 1 other identifier: GBS-Cardiac-Assiut-2026
• Study Type: observational
• Target: 72
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to identify and characterize cardiac changes including electrocardiographic, echocardiographic, and biochemical abnormalities in pediatric patients with Guillain-Barré syndrome.

Conditions

Myocardial Dysfunction; Guillain-Barre Syndrome

Keywords

Guillain-Barré syndrome; Assiut; ECG; Echocardiography; Myocardial changes; Pediatric

Outcome Measures

Primary Outcomes (1)

• Prevalence of cardiac abnormalities

  Proportion of patients with any cardiac abnormality detected by electrocardiography, echocardiography, or elevated cardiac biomarkers (troponin I or CK-MB).

  Baseline

Secondary Outcomes (5)

• Prevalence of electrocardiographic abnormalities

  Baseline

• Mean left ventricular ejection fraction (LVEF)

  Baseline

• Prevalence of elevated cardiac troponin I

  Baseline

• Prevalence of cardiac abnormalities at follow-up

  At 3 months

• Mean left ventricular ejection fraction at follow-up

  At 3 months

Study Arms (1)

Single cohort: Pediatric patients with Guillain-Barré syndrome

Pediatric patients with confirmed Guillain-Barré syndrome who will undergo cardiac evaluation at admission and at 3-month follow-up.

Eligibility Criteria

• Age: 1 Month - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients aged 1 month to 18 years with confirmed Guillain-Barré syndrome admitted to Assiut University Children's Hospital.

You may qualify if:

• Age 1 month to 18 years
• Confirmed diagnosis of Guillain-Barré syndrome
• Onset of neurological symptoms within 2 weeks prior to hospital presentation
• No pre-existing cardiac disease
• Written informed consent from parents or legal guardians

You may not qualify if:

• Pre-existing congenital or acquired heart disease
• Pre-existing neuromuscular disorders or hereditary peripheral neuropathies
• Incomplete cardiac workup (inability to perform ECG, echocardiography, and cardiac biomarker assessment)
• Loss to follow-up before hospital discharge

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Guillain-Barre Syndrome

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Faisal A Ahmed, prof

  Pediatrics Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

maria m monir, Resident

CONTACT

+20 10 20193392; mariamedmagdy@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Department of Pediatrics

Study Record Dates

• First Submitted: September 21, 2026
• First Posted: September 25, 2026
• Study Start: September 26, 2026
• Primary Completion (Estimated): September 26, 2027
• Study Completion (Estimated): January 25, 2028
• Last Updated: September 25, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share