Exploring the Impact of Diurnal Variation on Coagulation Function in Patients Undering Tumor Surgery

NCT07841613 | Enrolling By Invitation DMC

• 1 other identifier: FudanU25.4.21
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Studies have shown that compared to the evening, the platelet adhension and aggregation functions of normal individuals are stronger in the morning, reaching peak at around 8AM or 9AM. Fibrinolysis is weakest at 7-11AM, and most active at midnight. previous studies have been contradictory regarding the rhythm of plasmin. Some show the level of plasmin complexes is highest at night, while some show higher in the morning and some show there is no rhythmicity. Since patients with tumors often have a hypercoagulable state, we try to find a method to assess whether cancer patients have the same circadian with heathy individuals. And whether the surgery time(in the morning or in the evening) will affect the tumor patients' postoperative coagulation function

Conditions

Diurnal Variation of Coagulation Function

Outcome Measures

Primary Outcomes (1)

• preoperative TEG values

  one day

Study Arms (2)

morning surgery group

night surgery group

Other: No Biologics

Interventions

No Biologics OTHER

no intervention

night surgery group

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The subjects of the study were 83 patients scheduled for gastrointestinal tumor surgery under general anesthesia.

You may qualify if:

• \) Patients who signed the informed consent form and were willing to complete the study according to the protocol.
• \) Patients who underwent surgical treatment for digestive tract tumors. 3) The operation start time was from 8:00 to 9:00 in the morning and from 19:00 to 20:00 in the evening.
• \) ASA grade I-II. 5) Age ranging from 20 to 70 years old.

You may not qualify if:

• \) History of thrombosis-related diseases 2) Use of anticoagulants (excluding aspirin, which should be discontinued for one week) 3) Hb \< 90g/dL 4) Diabetic patients \[14\] 5) Patients admitted to ICU after surgery 10) Those who have participated in other clinical trials or refused to join the study.

Sponsors & Collaborators

• Fudan University: lead

Study Sites (1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, 200333, China

Location

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: chief of anesthesia at Fudan University Cancer Center

Study Record Dates

• First Submitted: September 20, 2026
• First Posted: September 25, 2026
• Study Start: June 1, 2025
• Primary Completion (Estimated): December 30, 2026
• Study Completion (Estimated): July 30, 2027
• Last Updated: September 25, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)