Role of PCGEM1 in Breast Cancer

NCT07562789 | Not Yet Recruiting

• 1 other identifier: Breast cancer and PCGEM1
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study examines certain molecular markers in breast cancer using blood and tissue samples from routine diagnostic biopsies. No extra procedures will be performed on patients. The goal is to improve understanding of disease mechanisms and identify potential targets for treatment

Conditions

Breast Cancer

Keywords

breast cancer, long non-codingRNA

Outcome Measures

Primary Outcomes (1)

• Relative expression level of PCGEM1 marker in breast cancer tissue and blood sample

  This outcome measures the relative expression level of PCGEM1 in breast cancer tissue and blood samples compared to control using quantitative real-time PCR (qRT-PCR). The results will be correlated with clinicopathological parameters.

  at base line

Study Arms (1)

female breast cancer patients and matched control - no intervention

Device: No Biologics

Interventions

No Biologics DEVICE

No intervention will be performed in this study. Tissue samples will be obtained from routine diagnostic biopsies that are already indicated as part of standard clinical care

female breast cancer patients and matched control - no intervention

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

18 years and older newly diagnosed female patients with histopathological confirmation of the diagnosis of breast cancer at any stage and matched control

You may qualify if:

• Age: 18 years and older.
• Newly diagnosed patients with histopathological confirmation of the diagnosis of breast cancer at any stage.

You may not qualify if:

• Presence of any chronic diseases.
• Previous history of breast cancer or other malignancies.
• Evidence of distant metastasis at the time of diagnosis.
• Prior treatment with chemotherapy or radiotherapy.
• Incomplete clinical or laboratory data.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Kumar S, Prajapati KS, Singh AK, Kushwaha PP, Shuaib M, Gupta S. Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer. Cancer Lett. 2021 Apr 28;504:15-22. doi: 10.1016/j.canlet.2020.11.039. Epub 2021 Feb 6.

  PMID: 33556545 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Central Study Contacts

Rehab M Ahmed

CONTACT

00201003804148; rehabmostafa998@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecturer

Study Record Dates

• First Submitted: April 26, 2026
• First Posted: May 1, 2026
• Study Start: May 5, 2026
• Primary Completion (Estimated): July 5, 2026
• Study Completion (Estimated): August 6, 2026
• Last Updated: May 1, 2026

Record last verified: 2026-04