Intraoperative Ketamine Versus Lidocaine Infusion on Postoperative Cognitive Dysfunction in Patients Undergoing Hip Surgery

NCT07838909 | Completed

• 1 other identifier: 36265MD386/3/25
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare effects of ketamine versus lidocaine on postoperative cognitive dysfunction in geriatric patient undergoing hip surgery.

Conditions

Ketamine; Cognitive; Dysfunction; Hip Surgeries

Keywords

Hip Surgery; elderly; Ketamine; Cognitive Dysfunction; Lidocaine

Outcome Measures

Primary Outcomes (1)

• Incidence of postoperative cognitive dysfunction

  3 days

Secondary Outcomes (1)

• Postoperative pain score

  24 hours postoperatively

Study Arms (3)

Group Ketamine

EXPERIMENTAL

Patients will receive ketamine as a bolus (0.5 mg/kg) after induction of spinal anesthesia, followed by a continuous infusion (0.2 mg/kg. h) until the end of surgery.

Drug: Group Ketamine

Group Lidocaine

EXPERIMENTAL

Patients will receive lidocaine as a bolus (1.5 mg/kg) after induction of spinal anesthesia, followed by a continuous infusion (2 mg/kg. h) until the end of surgery.

Drug: Group Lidocaine

Group Placebo

PLACEBO COMPARATOR

Patients will receive placebo (saline) and administered in equal volumes and in the same manner as a control group.

Drug: Group Placebo

Interventions

Group Ketamine DRUG

Patients will receive ketamine as a bolus (0.5 mg/kg) after induction of spinal anesthesia, followed by a continuous infusion (0.2 mg/kg. h) until the end of surgery.

Group Ketamine

Group Lidocaine DRUG

Patients will receive lidocaine as a bolus (1.5 mg/kg) after induction of spinal anesthesia, followed by a continuous infusion (2 mg/kg. h) until the end of surgery

Group Lidocaine

Group Placebo DRUG

Patients will receive placebo (saline) and administered in equal volumes and in the same manner as a control group.

Group Placebo

Eligibility Criteria

• Age: 66 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Both sexes of Elderly patient Aged \>65 years.
• American Society of Anesthesiologists classification I-III.
• Undergoing hip surgery under spinal anesthesia.

You may not qualify if:

• Patient refusal.
• History of mental illness or scoring less than 8 using abbreviated mental test before operation as in table 3 .
• Obvious sinus bradycardia (heart rate of \<50 beats per minute) or other serious cardiovascular diseases.
• Symptomatic cerebrovascular disease (such as previous stroke).
• History of liver and kidney dysfunction.
• Allergy to lidocaine or ketamine.
• Metabolic disorders and fluid, electrolytes disturbances.
• Alcohol dependence or drug abuse.
• Redo surgery or infectious complications.
• Central nervous system medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).
• History of deep vein thrombosis.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, Egypt

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: September 18, 2026
• First Posted: September 24, 2026
• Study Start: March 30, 2025
• Primary Completion: March 30, 2026
• Study Completion: March 30, 2026
• Last Updated: September 24, 2026

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

EG (1)