Hydrogen Peroxide 40% Versus Salicylic Acid 40% for Plantar Warts

NCT07830979 | Not Yet Recruiting Phase 3

• 1 other identifier: Plantar-Warts-H2O2-SA-Assiut-2
• Study Type: interventional
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled trial aims to compare the efficacy and safety of topical hydrogen peroxide 40 percent versus topical salicylic acid 40 percent in the treatment of plantar warts.

Conditions

Plantar Wart

Keywords

Hydrogen peroxide; Salicylic acid; Plantar warts; Topical treatment; HPV

Outcome Measures

Primary Outcomes (1)

• Number of participants with complete clinical clearance

  Number of participants with complete clinical clearance defined as complete disappearance of plantar wart and restoration of normal skin markings

  At 12 weeks

Secondary Outcomes (6)

• Time to complete clearance

  Up to 12 weeks

• Change in wart surface area

  From baseline to 12 weeks

• Treatment-related pain score

  Up to 12 weeks

• Number of participants with local adverse effects

  Up to 12 weeks

• Patient satisfaction score

  At 12 weeks

Study Arms (2)

Topical Hydrogen Peroxide 40%

EXPERIMENTAL

Stabilized topical hydrogen peroxide 40 percent w/w applied directly onto wart surface using single-use wooden-tipped applicator avoiding surrounding skin once weekly by physician for 12 weeks or until complete clearance after soaking foot 5 to 10 minutes and gentle debridement

Drug: Hydrogen Peroxide 40%

Topical Salicylic Acid 40%

ACTIVE COMPARATOR

Commercially available salicylic acid 40 percent w/w as paint or plaster self-applied once daily onto wart surface with protection of surrounding skin with petrolatum for 12 weeks after soaking and gentle paring

Drug: Salicylic Acid 40%

Interventions

Hydrogen Peroxide 40% DRUG

Topical hydrogen peroxide 40 percent w/w solution in opaque light-protected applicator bottle applied once weekly for up to 12 weeks

Topical Hydrogen Peroxide 40%

Salicylic Acid 40% DRUG

Topical salicylic acid 40 percent w/w preparation applied once daily for up to 12 weeks

Topical Salicylic Acid 40%

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Age greater than or equal to 12 years of both sexes
• Clinically diagnosed plantar wart or warts
• Wart duration at least 2 weeks prior to enrollment
• Willing and able to give written informed consent or parental consent for minors
• Able to attend follow-up visits and comply with home-application protocol

You may not qualify if:

• Pregnant or lactating women
• Immunocompromised patients including HIV infection organ transplant recipients or on immunosuppressive therapy
• Diabetic patients with peripheral neuropathy or peripheral arterial disease
• Known hypersensitivity to hydrogen peroxide or salicylic acid
• Received any topical or systemic wart treatment within preceding 4 weeks
• Clinically atypical lesions raising suspicion of malignancy
• Active local skin infection or open wound at treatment site
• Unable or unwilling to complete follow-up schedule

Sponsors & Collaborators

• Assiut University: lead

Study Officials

• Saher A Moez, prof

  Dermatology Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Mohamed A Abdel rady, Resident

CONTACT

01024907721; mohamedradybalela199769@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Department of Dermatology, Venereology and Andrology

Study Record Dates

• First Submitted: September 15, 2026
• First Posted: September 21, 2026
• Study Start: September 20, 2026
• Primary Completion (Estimated): September 20, 2027
• Study Completion (Estimated): February 20, 2028
• Last Updated: September 22, 2026

Record last verified: 2026-09