Plantar Wart Treatment Using Adapalene Gel

NCT04823845 | Withdrawn Early Phase 1 FDA Drug

• 1 other identifier: 20.1175
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study seeks to research the efficacy of Adapalene 0.1% gel as a cost effective and low risk treatment option for plantar warts of the foot. Patients that present/diagnosed in designated clinics with plantar warts will be offered the option of being treated with regular superficial debridements of the epidermis and twice a day application of adapalene gel 0.1% under occlusion. Patients will be followed until resolution.

Conditions

Plantar Wart

Keywords

Wart; Adapalene

Outcome Measures

Primary Outcomes (1)

• Time Until Plantar Wart Resolution

  days

  30-60 days

Study Arms (1)

Plantar Wart Treatment Using Adapalene Gel 0.1%

EXPERIMENTAL

patients treated for plantar warts with Adapalene 0.1% gel

Drug: Topical Adapalene Gel 0.1%

Interventions

Topical Adapalene Gel 0.1% DRUG

applying Adapalene Gel 0.1% to plantar warts topically

Plantar Wart Treatment Using Adapalene Gel 0.1%

Eligibility Criteria

• Age: 6 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• patients must be diagnosed with plantar warts

You may not qualify if:

• pregnant women
• previous wart treatment within the last 2 weeks

Sponsors & Collaborators

• University of Louisville: lead

Related Publications (3)

• Gupta R, Gupta S. Topical adapalene in the treatment of plantar warts; randomized comparative open trial in comparison with cryo-therapy. Indian J Dermatol. 2015 Jan-Feb;60(1):102. doi: 10.4103/0019-5154.147835.

  PMID: 25657417 BACKGROUND

• Gupta R. Plantar warts treated with topical adapalene. Indian J Dermatol. 2011 Sep-Oct;56(5):513-4. doi: 10.4103/0019-5154.87135.

  PMID: 22121266 BACKGROUND

• Vlahovic TC, Khan MT. The Human Papillomavirus and Its Role in Plantar Warts: A Comprehensive Review of Diagnosis and Management. Clin Podiatr Med Surg. 2016 Jul;33(3):337-53. doi: 10.1016/j.cpm.2016.02.003. Epub 2016 Mar 29.

  PMID: 27215155 BACKGROUND

MeSH Terms

Conditions

Warts

Condition Hierarchy (Ancestors)

Papillomavirus Infections; DNA Virus Infections; Virus Diseases; Infections; Skin Diseases, Viral; Tumor Virus Infections; Skin Diseases, Infectious; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Masking Details: patient information will be kept secure and no individual identifiers will be used.
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: apply study treatment to single group of patients.

Study Record Dates

• First Submitted: March 5, 2021
• First Posted: April 1, 2021
• Study Start: May 1, 2022
• Primary Completion: December 10, 2022
• Study Completion: February 10, 2023
• Last Updated: April 13, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share