Evaluation of the Role of Luteinizing Hormone (LH) and Human Chorionic Gonadotropin (hCG) in Adult Patients Undergoing Assessment for Endocrine Disorders

NCT07824102 | Recruiting

• 1 other identifier: H-24076355
• Study Type: observational
• Target: 20,000
• Locations: 1 country
• Sites: 1

Brief Summary

Hormones are chemical messengers that help regulate many functions in the body. As women go through menopause, and as men age, levels of certain reproductive hormones change significantly. One of these hormones, luteinizing hormone (LH), increases substantially after menopause and may also rise in some men. Another hormone, human chorionic gonadotropin (hCG), is best known as the hormone of pregnancy, but small amounts can also be detected in some postmenopausal women and older men. Recent research suggests that LH and hCG may have effects beyond reproduction. These hormones may influence bone health, body weight, kidney function, thyroid function, and adrenal gland function. However, little is known about their importance in patients with endocrine disorders. The purpose of this study is to investigate whether blood levels of LH and hCG are associated with the presence, severity, and long-term outcomes of endocrine diseases. The study will include adult patients undergoing evaluation for hormonal disorders. Blood samples will be analyzed for LH, hCG, and other relevant hormones and biomarkers. Participants will also be followed through national health registries to examine whether these hormone levels are associated with future health outcomes. The results of this study may improve our understanding of how LH and hCG affect the body and help determine whether these hormones can be used as biomarkers to improve the diagnosis and management of endocrine diseases.

Conditions

Osteoporosis; Hypercalcemia; Adrenal Gland Disease; Pituitary Disease; Thyroid Diseases; Primary Hyperparathyroidism

Outcome Measures

Primary Outcomes (1)

• Association between serum LH and hCG and risk of major osteoporotic fracture (MOF)

  Among patients with suspected or confirmed osteoporosis

  From baseline up to 5-, 10-, and 15-year follow-up

Secondary Outcomes (7)

• Association between serum LH and hCG and risk of later diagnosis of osteoporosis

  From baseline up to 5-, 10-, and 15-year follow-up

• Association between serum LH and hCG and urinary calcium/phosphate ratio

  Baseline association

• Association between serum LH and hCG and serum T4/T3 ratio

  Baseline association

• Association between serum LH and hCG and risk of T3 treatment initiation

  From baseline up to 5-, 10-, and 15-year follow-up

• Association between serum LH and hCG and risk malignant adrenal tumor

  From baseline up to 5-, 10-, and 15-year follow-up

Study Arms (5)

Patients with presumed osteoporosis

Patients with presumed Hypercalcemia / Primary Hyperparathyroidism

Patients with presumed thyroidal illness

Patients with presumed adrenal disease

Patients with presumed pituitary disease

Eligibility Criteria

• Age: 18 Years - 90 Years
• Gender Eligibility Details: Cisgender men and women
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients referred or followed at the Department of Endocrinology and Internal Medicine, Herlev Hospital for suspected or confirmed: Osteoporosis, Hypercalcemia/PHPT, thyroid disease, adrenal disease, pituitary disease.

You may qualify if:

• Patients referred to or patients actively followed at the Department of Endocrinology and Internal Medicine at Herlev Hospital
• Age 18-90

You may not qualify if:

• Lacking mental capacity to provide informed consent

Sponsors & Collaborators

• Martin Blomberg Jensen: lead
• Copenhagen University Hospital at Herlev: collaborator

Study Sites (1)

Department of Endocrinology and Internal Medicine, Herlev Hospital

Herlev, 2730, Denmark

RECRUITING

Related Publications (43)

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Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum and Urine

MeSH Terms

Conditions

Osteoporosis; Hypercalcemia; Hyperparathyroidism, Primary; Adrenal Gland Diseases; Pituitary Diseases; Thyroid Diseases

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Calcium Metabolism Disorders; Water-Electrolyte Imbalance; Hyperparathyroidism; Parathyroid Diseases; Endocrine System Diseases; Hypothalamic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Central Study Contacts

Martin B Jensen, Professor

CONTACT

+4538687318; martin.blomberg.jensen@regionh.dk

Mads J Jorsal, MD

CONTACT

mads.joon.jorsal@regionh.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 11, 2026
• First Posted: September 17, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): December 1, 2045
• Study Completion (Estimated): December 1, 2045
• Last Updated: September 17, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)