Impact of an e-Bug Educational Intervention on HPV and Meningococcal ACWY Vaccine Uptake in Middle School Students

NCT07824076 | Completed

• 1 other identifier: 26SantéMentale02
• Study Type: observational
• Target: 53,608
• Locations: 1 country
• Sites: 1

Brief Summary

"This study is a non-interventional observational pilot analysis assessing the possible impact of an educational programme (e-Bug) on parental consent and HPV and meningococcal ACWY vaccination uptake during the 2025-2026 national school-based vaccination campaigns in France. The study focuses on one middle school in the Alpes-Maritimes department and PACA region where teachers and the school nurse had been previously trained on vaccination and used e-Bug educational resources in class as part of routine health education. No research-related intervention was conducted, and the educational programme was not introduced or modified for the purpose of the study. Only aggregated and anonymised vaccination data were used. These data were routinely collected by the Regional Health Agency (ARS PACA) as part of the national vaccination programme and transmitted for analysis. Aggregated data from the pilot school were compared with departmental-level outcomes to describe whether an upstream educational approach may be associated with improved parental acceptance and higher hpv and meningococcal acwy vaccination coverage. This study aims to contribute to the understanding of educational determinants of vaccine uptake in a real-life school setting without involving any participant recruitment or individual data collection."

Conditions

HPV Coverage; Meningitidis Infections; Vaccination Coverage; Meningococcal ACWY Vaccines

Outcome Measures

Primary Outcomes (1)

• HPV and Meningococcal ACWY vaccination uptake (1st and 2nd doses) in the pilot school compared with departmental and region data

  Aggregated rates of HPV and Meningococcal ACWY vaccination uptake (first and second doses) among 5th-grade students in the pilot middle school using the e-Bug educational programme, compared with aggregated departmental and region vaccination rates from all other middle schools in the PACA area.

  From (start of 2025 HPV and Meningococcal ACWY vaccination campaign) to (end of 2025-2026)

Secondary Outcomes (2)

• Parental consent rate (acceptability)

  One school years 2025-2026

• Response rate (return of vaccination authorisation forms)

  one school years: 2025-2026

Study Arms (2)

Pilot School Using e-Bug Programme

The intervention consisted of a school-based educational programme implemented before the national vaccination campaign using MenACWY-specific e-Bug educational resources. Age-appropriate classroom activities addressed meningococcal disease, transmission, disease severity, prevention, and vaccination. The intervention also involved close collaboration between teachers and the school nurse, communication with families, and active follow-up of non-responding parents.

Behavioral: e-Bug School-Based Educational Intervention

Other Middle Schools in Alpes-Maritimes Department and PACA region

Students participated in the national school-based vaccination campaign and received the standard information materials provided as part of the campaign. No MenACWY-specific e-Bug educational intervention was implemented in these schools during the study period.

Behavioral: Standard School-Based Vaccination Campaign

Interventions

e-Bug School-Based Educational Intervention BEHAVIORAL

The intervention consisted of a school-based educational programme implemented before the national vaccination campaign using MenACWY-specific e-Bug educational resources. Age-appropriate classroom activities addressed meningococcal disease, transmission, disease severity, prevention, and vaccination. The intervention also involved close collaboration between teachers and the school nurse, communication with families, and active follow-up of non-responding parents.

Pilot School Using e-Bug Programme

Standard School-Based Vaccination Campaign BEHAVIORAL

Students participated in the national school-based vaccination campaign and received the standard information materials provided as part of the campaign. No MenACWY-specific e-Bug educational intervention was implemented in these schools during the study period.

Other Middle Schools in Alpes-Maritimes Department and PACA region

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Aggregated data from 5th-grade students enrolled in one pilot middle school using the e-Bug programme, compared with aggregated data from all other middle schools in the Alpes-Maritimes department and PACA region. No individual-level data were accessed.

You may qualify if:

• No individual participants are enrolled. The study uses only aggregated, anonymised vaccination data routinely collected by ARS PACA.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

CHU de Nice

Nice, Alpes Maritimes, 06000, France

Location

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 11, 2026
• First Posted: September 17, 2026
• Study Start: May 1, 2026
• Primary Completion: June 30, 2026
• Study Completion: September 1, 2026
• Last Updated: September 17, 2026

Record last verified: 2026-09

Locations

FR (1)