NCT07817576

Brief Summary

The goal of this observational study is to learn how blood levels of biomarkers, e.g. hsCRP and Lp(a) - two markers linked to heart disease risk - change over time in patients who have had these levels tested more than once. The main questions it aims to answer are: How often does a high result on a first test return to normal on a later test? Do patients whose levels stay high across repeated tests have a higher risk of death than patients whose high level was only temporary

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
110,000

participants targeted

Target at P75+ for all trials

Timeline
40mo left

Started Jan 2004

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress88%
Jan 2004Jan 2030

Study Start

First participant enrolled

January 1, 2004

Completed
21.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2025

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

September 2, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

September 14, 2026

Completed
3.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2030

Expected
Last Updated

September 14, 2026

Status Verified

September 1, 2026

Enrollment Period

21.5 years

First QC Date

September 2, 2026

Last Update Submit

September 9, 2026

Conditions

Heart FailureASCVDCKD

Keywords

RetrospectiveCardiovascular DiseasePrognosishsCRPLipoprotein (a)BiomarkerOutcomeVariability

Outcome Measures

Primary Outcomes (1)

  • Mortality

    From registration office (Meldeamt)

    Mortality is assessed at a defined time point (23rd June, 2026) as provided by the registration office (deceased yes/no)

Study Arms (5)

Total Cohort

Total Cohort

≥2 Test Cohort

≥3 Test Cohort

≥4 Test Cohort

≥5 Test Cohort

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Agnostic design. All-comers cohort at the University Hospital Freiburg, Department of Cardiology. Locations Freiburg and Bad-Krozingen

You may qualify if:

  • \- Available Biomarker Measurement

You may not qualify if:

  • \- \< 18 years, Biomarker not available

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Cardiology - Freiburg - Bad Krozingen

Freiburg im Breisgau, Germany

Location

MeSH Terms

Conditions

Heart FailureCardiovascular Diseases

Condition Hierarchy (Ancestors)

Heart Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Consultant

Study Record Dates

First Submitted

September 2, 2026

First Posted

September 14, 2026

Study Start

January 1, 2004

Primary Completion

July 1, 2025

Study Completion (Estimated)

January 1, 2030

Last Updated

September 14, 2026

Record last verified: 2026-09

Data Sharing

IPD Sharing
Will not share

Locations

DE(1)