Wrist Nerve Block as a New Treatment in Patients With Rheumatoid Arthritis

NCT07814989 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-7-26MS
• Study Type: interventional
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

Rheumatoid arthritis is a chronic, systemic, autoimmune inflammatory disease that mainly affects the joints and periarticular soft tissues.\[1\]

Conditions

Rhematoid Arthritis

Keywords

Rheumatoid Arthritis; Nerve block; Wrist injection

Outcome Measures

Primary Outcomes (2)

• Change in wrist pain severity measured by the Visual Analogue Scale (VAS) from baseline to Week 16

  Change in wrist pain severity measured using the Visual Analogue Scale (VAS) from baseline to Week 16 Visual Analogue Scale (VAS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Wrist pain severity will be assessed using the Visual Analogue Scale (VAS), ranging from 0 to 10, where 0 represents no pain and 10 represents the worst imaginable pain. Higher scores indicate greater pain. The change in VAS score from baseline to Week 16 will be assessed.

  Baseline to Week 16

• Assessment of wrist pain improvement

  • Change in wrist pain severity measured by the Visual Analogue Scale (VAS) from baseline to Week 16

  16 weeks

Study Arms (3)

Group 1

ACTIVE COMPARATOR

wrist nerve block

Procedure: Wrist local steroid injection

Group 2

PLACEBO COMPARATOR

wrist local steroid injection

Procedure: Wrist local steroid injection

Group 3

NO INTERVENTION

Interventions

Wrist local steroid injection PROCEDURE

Wrist nerve block by injection is a diagnostic or therapeutic procedure used to treat chronic wrist pain, typically arising from arthritis or instability, by interrupting sensory nerve signals (mainly PIN/AIN nerves) with an anesthetic or neurolytic agent. This less-invasive approach provides pain relief, often serving as a predictor for success before permanent surgical denervation.\[4\]

Group 1; Group 2

Eligibility Criteria

• Age: 16 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• RA patients fulfilled the 2010 American College of Rheumatoid Arthritis classification criteria.\[8\]
• Oligoarticular RA patients including wrist joint.
• Age above 18 years old.
• Patient cooperative and can answer questions.

You may not qualify if:

• Other rheumatologic or collagen diseases.
• Age below 18 years.
• Patients who underwent concomitant procedures to address underlying pathology such as radial styloidectomy, ulna shortening, fracture fixation, arthroplasty, arthrodesis, and ligament reconstructions.
• Patients who suffered from hand deformities or limitation.
• Uncooperative patients.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hospital

Sohag, Egypt

Location

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Youssra Ali Resident

CONTACT

00201122040682; youssralam3ie@gmail.com

Ahmed mahrous elsamman

CONTACT

00201122040682

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: August 30, 2026
• First Posted: September 11, 2026
• Study Start: August 15, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: September 11, 2026

Record last verified: 2026-07

Locations

EG (1)