Metabolic and Nutritional Responses to Acute High-intensity Interval Exercise Performed Under Hypoxic vs. Normoxic Conditions at Matched External Workload in Adults With Overweight and Obesity.

NCT07814599 | Completed

• 1 other identifier: IRB00012476-2024-23-09-342
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity management involves lifestyle and dietary measures that include appropriate nutrition and increased physical activity (PA). Among the various PA options available, HIIT (High-Intensity Interval Training) workouts are now recognized as fun and effective programs for promoting fat loss. To date, in overweight or obese individuals, only two studies mention the benefits of HIIT performed under hypoxia for modulating body composition, and more specifically, reducing the amount of adipose tissue. These studies hypothesize an increased energy expenditure under hypoxia associated with a transient loss of appetite. In order, to further investigate the adaptations following HIIT under hypoxia versus normoxia, we propose to compare, in acute conditions, two HIIT sessions (simulated hypoxia-normobaric vs. normoxia) in overweight or obese subjects. The objective of this assessment is to compare, during exercise and recovery (+2h), oxygen consumption, corresponding energy expenditure, and carbohydrate and lipid utilization in hypoxic versus normoxic conditions. Given the potential influence of hypoxia on appetite, spontaneous food intake and energy expenditure post-24h will also be measured. Finally, since pleasure and perceived exertion are key parameters in adherence to an adapted physical activity (APA) program, these two concepts will also be evaluated through the subjects' experiences.

Conditions

Obesity & Overweight; Energy Expenditure; Substrate Oxidation

Keywords

high intensity interval exercise; hypoxia; substrate oxidation; appetite; energy intake

Outcome Measures

Primary Outcomes (1)

• Lipid oxidation after the exercise session (nromoxia and hypoxia).

  Determination of lipid and carbohydrate oxidation after the exercise (HIIE normoxia and hypoxia). Lipid aoxidation is measured from oxygen and carbon dioxide consumption (Metamax 3D Cortex).

  Measurement during two hours after the end of the exercise

Secondary Outcomes (3)

• Oxygen consumption during the recovery period

  Two hours after the end of the exercise

• Energy intakes 24 hours after the exercise

  24 hours post exercise

• Appetite

  Before exercise and after exercise (+0 min, +60 min, and +120 min).

Study Arms (2)

High Intensity Interval Exercise - Normoxia

EXPERIMENTAL

HIIE in normoxia

Other: HIIE - Normoxia

High Intensity Interval Exercise - Hypoxia

EXPERIMENTAL

HIIE in hypoxia

Other: HIIE - Hypoxia

Interventions

HIIE - Normoxia OTHER

Cycling HIIE in Normoxia: 60 x \[8 seconds at a power equivalent to 80-85% of HRmax followed by 12 seconds of active recovery at a power equivalent to 40% of HRmax\]

High Intensity Interval Exercise - Normoxia

HIIE - Hypoxia OTHER

Cycling HIIE in Hypoxia (FiO2: 15%): 60 x \[8 seconds at a power equivalent to 80-85% of HRmax followed by 12 seconds of active recovery at a power equivalent to 40% of HRmax\]

High Intensity Interval Exercise - Hypoxia

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- overweight or obesity (BMI between 25 kg/m2 and 35 kg/m2)

You may not qualify if:

• medical contraindications to intense physical activity
• taking ß-blocker
• diabete
• women taking hormonal replacement therapy

Sponsors & Collaborators

• Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques: lead
• CREPS Vichy Auvergne: collaborator

Study Sites (1)

CREPS Auvergne Rhône-Alpes / Vichy

Bellerive-sur-Allier, Allier, 03321, France

Location

MeSH Terms

Conditions

Obesity; Overweight; Hypoxia

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Respiratory

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Data collected on the volunteers will be made anonymous.
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2026
• First Posted: September 11, 2026
• Study Start: November 1, 2024
• Primary Completion: September 1, 2026
• Study Completion: September 1, 2026
• Last Updated: September 11, 2026

Record last verified: 2026-09

Locations

FR (1)