Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects

NCT07809334 | Enrolling By Invitation

• 1 other identifier: 00507/2020
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).

Conditions

Peri-implantitis

Keywords

Peri-implantitis; Surgical treatment

Outcome Measures

Primary Outcomes (2)

• Implant survival rate

  Clinical Examination: Number of implants treated for peri-implantitis present in the oral cavity at the latest follow-up over the overall number of implants treated, expressed in %

  From enrollment to the end of treatment at the 10-year follow-up visit

• Implant survival rate

  Percentage of implants still in place after surgical intervention

  10-year

Study Arms (1)

Patients rehabilitated with a dental implants affected by a crater-like defect

Subjects, who presented a single peri-implantitis crater-like lesion with a PD of ≥6 mm and no implant mobility. Exclusion criteria were as follows: 1. PD \<6 mm; 2. Class II defects (characterized by consistent horizontal bone loss); 3. Multiple defects; 4. Implant mobility; 5. No interest in participating in the study; 6. Implants placed by other clinicians.

Procedure: Reconstructive therapy

Interventions

Reconstructive therapy PROCEDURE

Intervention: Following the elevation of a muco-periosteal flap, all granulation tissue was completely removed from the defect area, by means of titanium curettes and a titanium brush under irrigation. Consequently, implant surfaces were covered with EDTA 24% for 2 min and chlorhexidine 1% gel for 2 min. Thereafter, the infrabony defects were filled with a deproteinized bovine bone mineral with 10% collagen. All patients were asked to follow an individualized supportive care program.

Patients rehabilitated with a dental implants affected by a crater-like defect

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects rehabilitated with oral dental implants who presented a single peri-implantitis crater-like lesion with a PD of ≥6 mm

You may qualify if:

• Patients rehabilitated with oral dental implants affected by peri-implantitis
• A single peri-implantitis crater-like lesion with a Probing depth ofof ≥6 mm
• No implant mobility,
• Smokers

You may not qualify if:

• Probing depth \<6 mm;
• Class II defects (characterized by consistent horizontal bone loss);
• Multiple defects;
• Implant mobility;
• Subjects not interested in participating in the study;

Sponsors & Collaborators

• University of Turin, Italy: lead

Study Sites (1)

S.C. Chirurgia Maxillo-facciale U

Torino, Italy

Location

Related Publications (1)

• Roccuzzo M, Mirra D, Pittoni D, Ramieri G, Roccuzzo A. Reconstructive treatment of peri-implantitis infrabony defects of various configurations: 5-year survival and success. Clin Oral Implants Res. 2021 Oct;32(10):1209-1217. doi: 10.1111/clr.13818. Epub 2021 Aug 16.

  PMID: 34352140 RESULT

MeSH Terms

Conditions

Peri-Implantitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 24, 2026
• First Posted: September 9, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): June 30, 2027
• Last Updated: September 9, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)