A Comparative Study Protocol Investigating the Association Between Intraoperative Hypotension and the Use of Ring- Versus Propofol-Based Anesthesia in Elderly Patients Undergoing Non-Cardiac Surgery

NCT07808125 | Completed

• 1 other identifier: KY20260824-KS-03
• Study Type: observational
• Target: 85,000
• Locations: 1 country
• Sites: 1

Brief Summary

we conducted this multicentre retrospective cohort study to evaluate the association between the choice of induction agent (ciprofol versus propofol) and the incidence of IOH in geriatric patients having non-cardiac surgery. We hypothesized that ciprofol use would be associated with a lower risk of clinically significant intraoperative hypotension and a reduced overall hypotension burden compared with propofol in routine clinical practice.

Conditions

Intraoperative Hypotension

Keywords

Ciprofol; Propofol; intraoperative hypotension; geriatric anaesthesia

Outcome Measures

Primary Outcomes (1)

• prolonged intraoperative hypotension

  The primary outcome was prolonged intraoperative hypotension (IOH) during general anaesthesia. IOH was defined as at least one intraoperative mean arterial pressure (MAP) measurement \<65 mm Hg recorded between anaesthesia induction and the end of anaesthesia.

  During the operation

Secondary Outcomes (3)

• IOH burden at the event level

  During the operation

• duration of individual IOH episodes

  During the operation

• number of IOH episodes

  During the operation

Study Arms (2)

Ciprofol

Anesthetic induction for surgical procedures utilizing ciprofol as the sole induction agent

Propofol

Anesthetic induction for surgical procedures utilizing propofol as the sole induction agent

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This was a multicentre retrospective observational study of elderly patients aged 65 years or older who underwent non-cardiac surgery at three hospitals between 1 January 2013 and 1 September 2024. The analysis included surgical procedures performed under general anaesthesia in which either ciprofol alone or propofol alone was used. Procedures with missing key identifiers, uncertain general-anaesthesia status, absent event records, invalid anaesthesia times, or an anaesthesia duration of 24 hours or longer were excluded. Procedures without at least one valid intraoperative MAP measurement within the anaesthesia time window, as well as records with missing age or invalid sex information, were also excluded. Missing preoperative MAP values were not an exclusion criterion. The final analytical population comprised approximately 85,000 surgical procedures.

You may qualify if:

• Surgical procedures recorded at the three participating hospitals: NanYi, AnYi, and ZhongDa
• Surgical procedures with a non-missing PATIENT\_ID
• Patients who received either ciprofol alone or propofol alone during anesthesia
• Surgical procedures performed under general anesthesia
• Surgical procedures with a corresponding record in the anesthesia event dataset
• Surgical procedures with valid anesthesia start and end times, including times supplemented from operation-room or event records when necessary
• Surgical procedures with an anesthesia duration greater than 0 minutes and less than 24 hours
• Surgical procedures with at least one valid intraoperative MAP measurement recorded within the anesthesia time window
• Patients with available age information
• Patients with a recorded sex of male or female

You may not qualify if:

• Surgical procedures with a missing PATIENT\_ID
• Procedures involving both ciprofol and propofol, neither drug, missing drug indicators, or other invalid drug coding
• Non-general anesthesia procedures or procedures for which the anesthesia method could not be confirmed as general anesthesia
• Surgical procedures with both the operation department and operation name missing
• Surgical procedures without a corresponding anesthesia event record
• Surgical procedures with invalid anesthesia timing, including an anesthesia end time earlier than or equal to the anesthesia start time
• Surgical procedures with an anesthesia duration of 24 hours or longer
• Surgical procedures without any valid intraoperative MAP measurement within the anesthesia time window
• Patients with missing age
• Records with sex values other than male or female

Sponsors & Collaborators

• Nanjing First Hospital, Nanjing Medical University: lead

Study Sites (1)

Nanjing First Hospital, Nanjing Medical University

Nanjing, Jiangsu, 210006, China

Location

Study Officials

• Yali Ge

  Nanjing First Hospital, Nanjing Medical University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 3, 2026
• First Posted: September 8, 2026
• Study Start: January 1, 2013
• Primary Completion: September 30, 2024
• Study Completion: September 30, 2024
• Last Updated: September 8, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)