Subclinical Renal Dysfunction in Rheumatoid Arthritis

NCT07805109 | Not Yet Recruiting

• 1 other identifier: RA-Renal-Assiut-2026
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

This comparative cross-sectional study aims to determine the prevalence of subclinical renal dysfunction in patients with rheumatoid arthritis and to evaluate its association with disease activity and inflammatory markers compared with age- and sex-matched healthy controls at Assiut University Hospitals.

Conditions

Rheumatoid Arthritis; Renal Dysfunction; Chronic Kidney Diseases

Keywords

Rheumatoid arthritis; Subclinical renal dysfunction; eGFR; Urine albumin-to-creatinine ratio

Outcome Measures

Primary Outcomes (1)

• Prevalence of subclinical renal dysfunction

  Proportion of participants with subclinical renal dysfunction, defined as the presence of reduced estimated glomerular filtration rate (eGFR \< 90 mL/min/1.73 m²) and/or elevated urine albumin-to-creatinine ratio (UACR ≥ 30 mg/g) in the absence of previously diagnosed chronic kidney disease.

  Baseline

Secondary Outcomes (5)

• Comparison of eGFR between groups

  Baseline

• Comparison of UACR between groups

  Baseline

• Correlation of subclinical renal dysfunction with disease activity

  Baseline

• Correlation of subclinical renal dysfunction with inflammatory markers

  Baseline

• Independent predictors of subclinical renal dysfunction

  Baseline

Study Arms (2)

Rheumatoid arthritis patients (n=80)

Adult patients diagnosed with rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria attending the Rheumatology outpatient clinic and inpatient wards at Assiut University Hospitals.

Healthy controls (n=40)

Age- and sex-matched apparently healthy individuals with no history of autoimmune disease or chronic kidney disease.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with rheumatoid arthritis attending the Rheumatology outpatient clinic and inpatient wards at Assiut University Hospitals, and age- and sex-matched healthy controls.

You may qualify if:

• Age 18 years or older
• For patient group: Diagnosis of rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria
• For control group: Age- and sex-matched apparently healthy individuals with no history of autoimmune disease or chronic kidney disease
• Willingness to provide written informed consent

You may not qualify if:

• Known chronic kidney disease
• Acute kidney injury
• Diabetes mellitus
• Uncontrolled hypertension
• Active urinary tract infection
• Pregnancy
• History of obstructive uropathy or renal stones
• Systemic lupus erythematosus or other connective tissue diseases
• Malignancy
• Patients on maintenance hemodialysis

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Boers M, Dijkmans BA, Breedveld FC, Camps JA, Chang PC, van Brummelen P, Pauwels EK, Cats A. Subclinical renal dysfunction in rheumatoid arthritis. Arthritis Rheum. 1990 Jan;33(1):95-101. doi: 10.1002/art.1780330113.

  PMID: 2302273 BACKGROUND

• Pedersen LM, Nordin H, Svensson B, Bliddal H. Microalbuminuria in patients with rheumatoid arthritis. Ann Rheum Dis. 1995 Mar;54(3):189-92. doi: 10.1136/ard.54.3.189.

  PMID: 7748016 BACKGROUND

• Daoussis D, Panoulas VF, John H, Toms TE, Antonopoulos I, Treharne G, Nightingale P, Douglas KM, Kitas GD. Microalbuminuria in rheumatoid arthritis in the post penicillamine/gold era: association with hypertension, but not therapy or inflammation. Clin Rheumatol. 2011 Apr;30(4):477-84. doi: 10.1007/s10067-010-1446-y. Epub 2010 Apr 16.

  PMID: 20396921 BACKGROUND

MeSH Terms

Conditions

Arthritis, Rheumatoid; Renal Insufficiency; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Essam m abd elaziz, prof

  Internal Medicine Department, Assiut University Hospitals, Assiut, Egypt

  STUDY CHAIR

Central Study Contacts

Nermeen E barsoum, resident

CONTACT

+201282868576; Nermin.18313211@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: An internal medicine resident physician

Study Record Dates

• First Submitted: September 1, 2026
• First Posted: September 4, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): June 1, 2028
• Last Updated: September 9, 2026

Record last verified: 2026-09