Musculoskeletal Ultrasound with Elastography in the Evaluation of Muscle State in Rheumatoid Arthritis Patients
1 other identifier
observational
72
0 countries
N/A
Brief Summary
Evaluation of muscle state in rheumatoid arthritis patients. Application of elastography in the detection of muscle stiffness in rheumatoid arthritis
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2024
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 6, 2024
CompletedFirst Posted
Study publicly available on registry
October 1, 2024
CompletedStudy Start
First participant enrolled
October 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2025
CompletedOctober 1, 2024
August 1, 2024
1.2 years
August 6, 2024
September 29, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Evaluation of muscle state in rheumatoid arthritis patients by using musculoskeletal us
Baseline
Secondary Outcomes (1)
Application of elastography in the detection of muscle stiffness in rheumatoid arthritis patients
Baseline
Study Arms (2)
Rheumatoid arthritis patients
Healthy control group
Interventions
Musculoskeletal Ultrasound with elastography
Eligibility Criteria
Patients will be divided into two groups matched for age and sex : Group A: rheumatoid arthritis will include 36 participants Group B: healthy participants (control) will include 36 participants
You may qualify if:
- Age 18:70 years
- RA patients with positive RF And Anti ccp
You may not qualify if:
- History of injury or operation of the lower limb and upper limbs .
- History or clinical signs of neuromuscular disorders.
- Patients on drugs causing myopathy or myositis
- History of chronic diseases : kidney and liver disease
- Diabetic patients .
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (4)
Frontera WR, Ochala J. Skeletal muscle: a brief review of structure and function. Calcif Tissue Int. 2015 Mar;96(3):183-95. doi: 10.1007/s00223-014-9915-y. Epub 2014 Oct 8.
PMID: 25294644BACKGROUNDBrennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 2008 Nov;118(11):3537-45. doi: 10.1172/JCI36389.
PMID: 18982160BACKGROUNDHuffman KM, Jessee R, Andonian B, Davis BN, Narowski R, Huebner JL, Kraus VB, McCracken J, Gilmore BF, Tune KN, Campbell M, Koves TR, Muoio DM, Hubal MJ, Kraus WE. Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability. Arthritis Res Ther. 2017 Jan 23;19(1):12. doi: 10.1186/s13075-016-1215-7.
PMID: 28114971BACKGROUNDLondhe P, Guttridge DC. Inflammation induced loss of skeletal muscle. Bone. 2015 Nov;80:131-142. doi: 10.1016/j.bone.2015.03.015.
PMID: 26453502BACKGROUND
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Resident
Study Record Dates
First Submitted
August 6, 2024
First Posted
October 1, 2024
Study Start
October 1, 2024
Primary Completion
December 30, 2025
Study Completion
December 30, 2025
Last Updated
October 1, 2024
Record last verified: 2024-08
Data Sharing
- IPD Sharing
- Will not share