Kinesiophobia Associated With Fatigue in Patients With Multiple Sclerosis.

NCT07803523 | Completed

• 1 other identifier: gunaytez
• Study Type: observational
• Target: 352
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the presence of kinesiophobia and the factors associated with kinesiophobia in patients diagnosed with multiple sclerosis. Adult volunteer patients aged 18-65 years with a diagnosis of multiple sclerosis who present to the Physical Medicine and Rehabilitation and Neurology outpatient clinics, meet the inclusion criteria, and provide written informed consent will be enrolled in the study. For each patient, Expanded Disability Status Scale (EDSS) scores, spasticity scores according to the Modified Ashworth Scale (MAS), and the Timed 25-Foot Walk Test will be assessed. In addition, the Functional Ambulation Scale, Visual Analog Scale (VAS) for pain, VAS for sleep, Tampa Scale for Kinesiophobia-Fatigue, International Physical Activity Questionnaire, and the Turkish versions of the Hospital Anxiety and Depression Scale will be completed for each patient.

Conditions

Kinesiophobia; Multiple Sclerosis

Keywords

Multiple sclerosis; Kinesiophobia; Fatigue; Tampa Scale for Kinesiophobia-Fatigue

Outcome Measures

Primary Outcomes (1)

• Tampa Scale for Kinesiophobia-Fatigue

  It is used to assess fatigue-related kinesiophobia. The scale consists of 17 items. Total scores range from 17 to 68, with higher scores indicating greater levels of kinesiophobia.

  Baseline

Secondary Outcomes (8)

• Visual Analog Scale (VAS)- pain

  Baseline

• Visual Analog Scale (VAS)- Sleep

  Baseline

• Functional Ambulation Scale (FAS)

  baseline

• International Physical Activity Questionnaire-Short Form (IPAQ-SF)

  baseline

• Hospital Anxiety and Depression Scale (HADS)

  baseline

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult volunteer patients aged 18-65 years with a diagnosis of multiple sclerosis who present to the Physical Medicine and Rehabilitation and Neurology outpatient clinics of Dokuz Eylul University Faculty of Medicine, meet the inclusion criteria, and provide written informed consent will be enrolled in the study.

You may qualify if:

• Age between 18 and 65 years, EDSS (Expanded Disability Status Scale) score ≤ 6, Mini-Mental State Examination score ≥ 24, Diagnosis of multiple sclerosis according to the 2017 revised McDonald criteria, Willingness to participate in the study.

You may not qualify if:

• Experiencing an MS relapse within the past 3 months, Having undergone a change in MS treatment within the past 3 months, EDSS (Expanded Disability Status Scale) score \> 6, Presence of another neurodegenerative disease in addition to MS, Presence of psychiatric, neurological, or other chronic diseases (other than MS) that may affect cognitive functions, Presence of orthopedic or rheumatologic diseases (other than MS) that may affect functional ambulation, Refusal to participate in the study.

Sponsors & Collaborators

• Dokuz Eylul University: lead

Study Sites (1)

Department of Physical Medicine and Rehabilitation, Medical Faculty of Dokuz Eylül University, İzmir, Turkey

Izmir, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Kinesiophobia; Multiple Sclerosis; Fatigue

Condition Hierarchy (Ancestors)

Phobic Disorders; Anxiety Disorders; Mental Disorders; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 31, 2026
• First Posted: September 3, 2026
• Study Start: May 28, 2025
• Primary Completion: December 30, 2025
• Study Completion: January 30, 2026
• Last Updated: September 3, 2026

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)