Predictors of Rapid CKD Progression

NCT07803237 | Not Yet Recruiting

• 1 other identifier: CKD-RapidProg-2026
• Study Type: observational
• Target: 190
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective observational cohort study aims to identify independent predictors of rapid chronic kidney disease (CKD) progression and determine its incidence among predialysis CKD patients. A total of 190 adult patients will be enrolled from the nephrology outpatient clinic and inpatient ward at Assiut University Hospitals and followed for 24 months. Rapid progression is defined as a sustained decline in eGFR \> 5 mL/min/1.73 m² per year according to KDIGO 2024 criteria. Clinical and laboratory parameters will be assessed at baseline and during follow-up to identify predictive factors

Conditions

Chronic Kidney Diseases; Kidney Failure; Chronic Renal Insufficiency; CKD; Kidney Failure, Chronic

Keywords

Chronic Kidney Disease; CKD; Predictors; Predialysis; eGFR

Outcome Measures

Primary Outcomes (1)

• Incidence of rapid CKD progression

  Proportion of participants who experience rapid CKD progression, defined as a sustained decline in eGFR greater than 5 mL/min/1.73 m² per year.

  24 months

Secondary Outcomes (3)

• Independent predictors of rapid CKD progression

  24 months

• Change in estimated glomerular filtration rate (eGFR)

  Baseline, 12 months, and 24 months

• Change in albuminuria

  Baseline, 12 months, and 24 months

Study Arms (1)

Predialysis CKD Patients

Adult patients with chronic kidney disease not receiving maintenance dialysis, followed prospectively for 24 months to assess rapid disease progression. This is an observational study with no intervention.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with predialysis chronic kidney disease (CKD) attending the Nephrology outpatient clinic and inpatient ward at Assiut University Hospitals.

You may qualify if:

• Age 18 years or older
• Diagnosis of CKD according to KDIGO 2024 criteria
• Predialysis status (not on maintenance dialysis)
• Ability to provide written informed consent
• Availability for 24-month follow-up

You may not qualify if:

• Acute kidney injury
• Current maintenance dialysis
• Previous kidney transplantation
• Active malignancy
• Pregnancy

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Ali I, Chinnadurai R, Ibrahim ST, Green D, Kalra PA. Predictive factors of rapid linear renal progression and mortality in patients with chronic kidney disease. BMC Nephrol. 2020 Aug 14;21(1):345. doi: 10.1186/s12882-020-01982-8.

  PMID: 32795261 BACKGROUND

• Lee FY, Islahudin F, Ali Nasiruddin AY, Abdul Gafor AH, Wong HS, Bavanandan S, Mohd Saffian S, Md Redzuan A, Mohd Tahir NA, Makmor-Bakry M. Effects of CYP3A5 Polymorphism on Rapid Progression of Chronic Kidney Disease: A Prospective, Multicentre Study. J Pers Med. 2021 Mar 30;11(4):252. doi: 10.3390/jpm11040252.

  PMID: 33808503 BACKGROUND

• Inaguma D, Hayashi H, Yanagiya R, Koseki A, Iwamori T, Kudo M, Fukuma S, Yuzawa Y. Development of a machine learning-based prediction model for extremely rapid decline in estimated glomerular filtration rate in patients with chronic kidney disease: a retrospective cohort study using a large data set from a hospital in Japan. BMJ Open. 2022 Jun 9;12(6):e058833. doi: 10.1136/bmjopen-2021-058833.

  PMID: 35680264 BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Effat A tony, prof

  Internal Medicine Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Noura D Fahmi, Resident

CONTACT

01225407990; Nura.18313461@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 24 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician department of internal medicine

Study Record Dates

• First Submitted: August 31, 2026
• First Posted: September 3, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): March 1, 2028
• Last Updated: September 3, 2026

Record last verified: 2026-08