NCT07798557

Brief Summary

Aim 1. Conduct a 6-month (24-session) RCT comparing MedDiet-WL to MedDiet-SN among 268 older adults with obesity (50-79 years, BMI = 30-50 kg/m²). We hypothesize that 1) Participants in MedDiet-SN will show improvements in bodyweight/BMI and body fat compared to MedDiet-WL at post-intervention (6-months), 2) Participants in MedDiet-SN will show improvements in diet (diet quality) and physical activity (step counts) compared to MedDiet-WL at post-intervention (6-months), and 3) Participants in MedDiet-SN will maintain these improvements at 12-months. Aim 2. Characterize and compare differences in weight management information dissemination by 268 randomized to MedDiet-WL and MedDiet-SN. We hypothesize that MedDiet-SN participants will share information to more network members compared to participants in MedDiet-WL. Aim 3. Compare MedDiet-SN and MedDiet-WL in 268 network members. We hypothesize that MedDiet-SN network members will show, greater improvements in BMI, body fat, diet, and physical activity than MedDiet-WL network members at 6 months. We will explore how effects may vary by network (e.g., density, relationships), and messaging characteristics (e.g., modality).

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
532

participants targeted

Target at P75+ for not_applicable

Timeline
40mo left

Started Feb 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress17%
Feb 2026Dec 2029

Study Start

First participant enrolled

February 1, 2026

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

August 25, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 1, 2026

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2029

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2029

Last Updated

September 1, 2026

Status Verified

August 1, 2026

Enrollment Period

3.4 years

First QC Date

August 25, 2026

Last Update Submit

August 27, 2026

Conditions

Obesity & Overweight

Outcome Measures

Primary Outcomes (4)

  • Physical Activity

    Godin-Shephard Leisure Time Physical Activity Questionnaire

    6 months

  • Anthropometrics, Body Fat

    BMI, body fat measure by stadiometer and scale

    6 months

  • Dietary Intake

    Vioscreen Food Frequency Questionnaire

    6 months

  • Mediterranean Diet adherence

    Mediterranean Eating Patterns for Americans (MEPA) is a 16-item screener that assesses adherence to a MedDiet pattern

    6 months

Secondary Outcomes (1)

  • Community Network Factors

    6 months

Other Outcomes (1)

  • Additional Measures for Co-Variates, Mediators and Moderators

    6 month

Study Arms (2)

MD-WL

ACTIVE COMPARATOR

Mediterranean Diet Weight Loss

Behavioral: Social Network Curriculum

MD-WL SN

ACTIVE COMPARATOR

Mediterranean Diet Weight Loss Social Networks

Behavioral: Social Network Curriculum

Interventions

Social Network CurriculumBEHAVIORAL

Empowerment to share lifestyle change information within social networks

Also known as: MD-WL SN
MD-WLMD-WL SN

Eligibility Criteria

Age50 Years - 79 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • yrs old,
  • BMI 30-50
  • Willing to participate in all procedures
  • Understand English
  • Willing to make changes to diet and lifestyle
  • Have access to a phone
  • Plan to reside in the Chicago area for the next 12 months

You may not qualify if:

  • Severe ischemic heart disease
  • Severe pulmonary disease
  • Bariatric surgery
  • Cancer treatment within the past 12 months
  • Current adherence to MedDiet based on dietary screening

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Illinois Chicago

Chicago, Illinois, 60608, United States

RECRUITING

MeSH Terms

Conditions

ObesityOverweight

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Central Study Contacts

Lara Blumstein, MA

CONTACT

+1 77304903311lbb@uic.edu

Marian Fitzgibbon, PhD

CONTACT

+1 77304903311lbb@uic.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

August 25, 2026

First Posted

September 1, 2026

Study Start

February 1, 2026

Primary Completion (Estimated)

June 30, 2029

Study Completion (Estimated)

December 31, 2029

Last Updated

September 1, 2026

Record last verified: 2026-08

Locations

US(1)