A Study for Postoperative Delirium in Older Patients With Intracranial Tumors

NCT07797660 | Not Yet Recruiting

• 1 other identifier: 2026-8
• Study Type: observational
• Target: 164
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative delirium is a common acute central nervous system syndrome, which often occurs 1-5 days after surgery. Postoperative delirium can prolong the length of hospital stay, increase the mortality rate, and is also associated with long-term postoperative cognitive dysfunction. However, the pathogenesis of postoperative delirium in elderly patients undergoing neurosurgical procedures, who are at high risk for ostoperative delirium, remains unclear. This study aims to elucidate the underlying mechanisms of postoperative delirium in this population and inform the development of effective prevention and treatment strategies.

Conditions

Delirium; Brain Tumor

Outcome Measures

Primary Outcomes (1)

• The association between intraoperative hypotension and postoperative delirium

  Intraoperative hypotension was defined by absolute mean arterial pressure (MAP) thresholds (sustained MAP \< 75, 70, 65, or 60 mm Hg for \> 1 min) or relative MAP reductions (10%, 20%, 30%, or 40% below preoperative baseline). The Confusion Assessment Method for the Intensive Care Unit scale (CAM-ICU) or 3 min diagnostic interview for CAM (3D-CAM) will be applied to assess postoperative delirium.

  The surgery day and twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days.

Secondary Outcomes (3)

• Characteristic of electroencephalogram

  The surgery day

• Regional cerebral oxygen saturation changes

  The surgery day

• Blood inflammatory factors

  The surgery day

Study Arms (2)

Intraoperative hypotension

Without intraoperative hypotension

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population will be selected from elderly patients scheduled to undergo elective craniotomy for intracranial tumour resection at Beijing Tiantan Hospital.

You may qualify if:

• Patients undergoing elective craniotomy for intracranial tumour resection
• Patients who will provide written informed consent

You may not qualify if:

• Patients with severe preoperative cognitive impairment precluding subsequent assessments
• History of psychotropic medication use
• Previous history of neurosurgical operation
• Severe bradycardia (heart rate \< 40 beats per minute)
• Sick-sinus syndrome or atrioventricular block of grade Ⅱ or above
• Severe hepatic insufficiency (Child-Pugh grade C)
• Renal failure requiring renal replacement therapy

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead

Study Sites (1)

Beijing Tian Tan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China

Location

MeSH Terms

Conditions

Delirium; Brain Neoplasms

Condition Hierarchy (Ancestors)

Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases

Central Study Contacts

Yuming Peng, M.D., Ph.D

CONTACT

8610-59976658; florapym766@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy chief of Department of Anesthesiology

Study Record Dates

• First Submitted: August 26, 2026
• First Posted: September 1, 2026
• Study Start: August 30, 2026
• Primary Completion (Estimated): August 30, 2027
• Study Completion (Estimated): September 30, 2027
• Last Updated: September 1, 2026

Record last verified: 2026-08

Locations

CN (1)