AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
AMBITION 7
Efficacy and Safety of Zenagamtide s.c. Once Weekly Compared to Insulin Glargine s.c. Once Daily in Participants With Type 2 Diabetes and Increased Cardiovascular Risk Inadequately Controlled on 1-3 Oral Glucose-lowering Medications (AMBITION 7)
3 other identifiers
interventional
1,778
16 countries
330
Brief Summary
This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already taking 1 to 3 diabetes medications. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get zenagamtide, (the treatment being tested) or insulin glargine (a comparator) and which treatment participants get is decided by chance.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 type-2-diabetes
Started Aug 2026
Typical duration for phase_3 type-2-diabetes
330 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 24, 2026
CompletedFirst Submitted
Initial submission to the registry
August 26, 2026
CompletedFirst Posted
Study publicly available on registry
September 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 20, 2028
September 1, 2026
August 1, 2026
1.9 years
August 26, 2026
August 26, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Non-inferiority of zenagamtide versus insulin glargine: change in haemoglobin A1c (HbA1c)
Measured as percentage (%)-points
From baseline (week 0) to week 52
Secondary Outcomes (9)
Time to first occurrence of a 4-point major adverse cardiovascular events (MACE) endpoint consisting of: Cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke and hospitalisation for unstable angina
From baseline (week 0) to 104 weeks or more
Relative change in body weight
From baseline (week 0) to week 52
Superiority of zenagamtide versus insulin: Change in HbA1c
From baseline (week 0) to week 52
Time to first occurrence of a 3-point MACE endpoint consisting of: CV death, non-fatal myocardial infarction and non-fatal stroke
From baseline (week 0) to 104 weeks or more
Change in waist circumference
From baseline (week 0) to week 52
- +4 more secondary outcomes
Study Arms (2)
Zenagamtide
EXPERIMENTALParticipants will receive zenagamtide subcutaneously once weekly to one of the body parts: thigh, abdomen or upper arm.
Insulin glargine U-100
ACTIVE COMPARATORParticipants will receive Insulin glargine U-100 subcutaneously once daily to one of the body parts: thigh, abdomen or upper arm.
Interventions
Insulin glargine U-100 will be administered subcutaneously using SoloSTAR pen-injector to one of the body parts: thigh, abdomen or upper arm (rotation of the injection site within body parts).
Zenagamtide will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm (administration to the same body part throughout the study).
Eligibility Criteria
You may qualify if:
- Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.
- Male or female (sex assigned at birth, inclusive of all gender identities).
- Age 45 years or above at the time of signing the informed consent.
- Diagnosed with type 2 diabetes (T2D) greater than or equal to (≥) 180 days before screening.
- Treatment with 1-3 marketed oral glucose-lowering medications (metformin, glinide, thiazolidinedione, sodium-glucose cotransporter-2 inhibitors (SGLT2i), α-glucosidase inhibitors (AGI), or sulfonylureas (SU) as a single agent or in combination) according to local label. Treatment with oral glucose-lowering medications must be stable (same drug(s), stable daily dose(s)) before screening.
- Have HbA1c as determined by central laboratory at screening, if background glucose-lowering medications does not include a SU, or if background glucose-lowering medications includes a SU.
- Increased risk of cardiovascular events as evidenced by at least one of the following (a-e):
- Prior myocardial infarction (MI)
- Documented coronary artery disease defined by at least one of the following:
- ≥ 50% stenosis of coronary artery on angiography or other imaging modality.
- Ischaemia documented by stress test with any imaging modality.
- Prior unstable angina with electrocardiogram (ECG) changes.
- Prior coronary artery bypass graft or prior percutaneous coronary intervention.
- Prior stroke (ischemic or haemorrhagic stroke).
- History of chronic kidney disease based on medical records or as judged by the investigator as determined by central laboratory at screening.
- +5 more criteria
You may not qualify if:
- Myocardial infarction, stroke, transient ischaemic attack or hospitalisation for unstable angina pectoris within 60 days before screening.
- Planned coronary, carotid or peripheral artery revascularisation.
- Chronic or intermittent haemodialysis or peritoneal dialysis within 90 days before screening.
- Diabetes- or weight related:
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), dipeptidyl peptidase 4 (DPP-4) inhibitors or amylin analogues before screening.
- Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) within 180 days before screening or are expected to require treatment within 180 days after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
- Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire question.
- Any episodes of diabetic ketoacidosis before screening.
- Uncontrolled thyroid disease as per investigator's discretion.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Novo Nordisk A/Slead
Study Sites (330)
Univ of Alabama Birmingham
Birmingham, Alabama, 35294, United States
Eastern Shore Rsrch Inst, LLC
Fairhope, Alabama, 36532, United States
Chambliss Clinical Trials, LLC
Montgomery, Alabama, 36106, United States
Honor Health
Scottsdale, Arizona, 85258, United States
First Valley Medical Group
Lancaster, California, 93534, United States
Headlands Research CTR Lincoln
Lincoln, California, 95648, United States
Torrance Clin Res Inst, Inc.
Lomita, California, 90717, United States
Pacific Clinical Studies
Los Alamitos, California, 90720, United States
VAGLAHS Clinical Research Center (CRC)
Los Angeles, California, 90073, United States
Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
Paradigm Clinical Research
San Diego, California, 92108, United States
N America Res Inst - San Dimas
San Dimas, California, 91773, United States
Encompass Clinical Research_Spring Valley
Spring Valley, California, 91978, United States
Innovative Research of W FL
Clearwater, Florida, 33756, United States
Nature Coast Clin Rsrch_Crystal River
Crystal River, Florida, 34429, United States
Florida Premier Cardiology
Delray Beach, Florida, 33484, United States
Encore Medical Research LLC
Hollywood, Florida, 33024, United States
East Coast Institute For Research
Jacksonville, Florida, 32216, United States
Jacksonville Ctr for Clin Res
Jacksonville, Florida, 32216, United States
Clinical Research of Cent FL
Lakeland, Florida, 33805, United States
Life Spring Research Foundation LLC
Miami, Florida, 33130, United States
Optimus U, Corp
Miami, Florida, 33135, United States
Flourish Research - North Miami
Miami, Florida, 33138, United States
Inpatient Research Clinic LLC
Miami Lakes, Florida, 33014, United States
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, 33014, United States
Trujillo Medical Centers
Miramar, Florida, 33027, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
Ocala Cardiovascular Research
Ocala, Florida, 34471, United States
Suncoast Clinical Research, Inc.
Palm Harbor, Florida, 34684, United States
Suncoast Research Associates LLC
Pembroke Pines, Florida, 33024, United States
St Johns Center for Clin. Res
Saint Augustine, Florida, 32086, United States
Javara/Privia Med Grp GA,LLC
Albany, Georgia, 31707, United States
David Kavtaradze MD, Inc.
Cordele, Georgia, 31015, United States
Atlanta Heart Specialist
Tucker, Georgia, 30084, United States
Rocky Mountain Diab&Osteo Ctr
Idaho Falls, Idaho, 83404, United States
Elevate Clinical Research
Gurnee, Illinois, 60031, United States
Chicago Medical Research LLC
Hazel Crest, Illinois, 60429, United States
Genesis Orthopedics & Sports Medicine
Oak Brook, Illinois, 60523, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636, United States
American Health Network of IN LLC_Franklin
Franklin, Indiana, 46131, United States
American Health Network of Indiana, LLC_Greenfield
Greenfield, Indiana, 46140, United States
American Health Network of IN LLC
Muncie, Indiana, 47304, United States
West Broadway Clinic
Council Bluffs, Iowa, 51501, United States
University of Iowa Prev Inter Ctr
Iowa City, Iowa, 52772, United States
Iowa Diab & Endo Res Center
West Des Moines, Iowa, 50266, United States
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, 66606, United States
The Research Group of Lexington LLC
Lexington, Kentucky, 40503, United States
Louisiana Heart Center
Covington, Louisiana, 70433, United States
Ascension Saint Agnes Heart Ca
Baltimore, Maryland, 21229, United States
MedStar Good Samaritan Hosp
Baltimore, Maryland, 21239, United States
Brigham & Women's Hospital
Boston, Massachusetts, 02115, United States
Henry Ford Health System
Detroit, Michigan, 48202, United States
Elite Research Center
Flint, Michigan, 48532, United States
Arcturus Healthcare, PLC.
Troy, Michigan, 48098, United States
Trinity Health Michigan Heart
Ypsilanti, Michigan, 48197, United States
Johnson County ClinTrials
Kansas City, Missouri, 64112, United States
Amicis Centers of Clinical Research
St Louis, Missouri, 63128, United States
Methodist Phys. Clinic
Omaha, Nebraska, 68114, United States
Palm Research Center Inc-Vegas
Las Vegas, Nevada, 89128, United States
Central New York Clinical Research CNYCR
Manlius, New York, 13104, United States
Mid Hudson Med Res-New Windsor
New Windsor, New York, 12553, United States
Harlem Cardiology_Madison ave
New York, New York, 10035, United States
NYC Health + Hospitals/Lincoln
The Bronx, New York, 10451, United States
Prime Global Research Inc.
The Bronx, New York, 10456, United States
Southgate Medical Group, LLP
West Seneca, New York, 14224, United States
Carteret Medical Group
Morehead City, North Carolina, 28557, United States
Piedmont Healthcare/Research
Statesville, North Carolina, 28625, United States
Accellacare
Winston-Salem, North Carolina, 27103, United States
Univ of Cincinnati Med Cent
Cincinnati, Ohio, 45267, United States
Advanced Med Res Maumee
Maumee, Ohio, 43537, United States
Lynn Institute of Norman
Norman, Oklahoma, 73072, United States
Heritage Valley Medical Group
Beaver, Pennsylvania, 15009, United States
Capital Area Research LLC
Newport, Pennsylvania, 17074, United States
Piedmont Research Partners, LLC
Fort Mill, South Carolina, 29707, United States
Accellacare US Inc._SC
Mt. Pleasant, South Carolina, 29464, United States
Trial Management Associates
Myrtle Beach, South Carolina, 29572, United States
Holston Medical Group Pc
Bristol, Tennessee, 37620-7352, United States
The Alliance for Multispecialty Research LLC AMR
Knoxville, Tennessee, 37909, United States
MidState Endocrine Associates
Nashville, Tennessee, 37203, United States
PharmaTex Research
Amarillo, Texas, 79106, United States
Pinnacle Clinical Research
Austin, Texas, 78757, United States
Javara Inc. / Privia Medical Group Gulf Coast PLLC
Conroe, Texas, 77384, United States
Osvaldo A. Brusco MD
Corpus Christi, Texas, 78414, United States
Thyroid Endocrinology & Diabetes PA
Dallas, Texas, 75208, United States
Baylor Jack and Jane Hamilton
Dallas, Texas, 75226, United States
Diabetes and Thyroid Ctr of FW
Fort Worth, Texas, 76132, United States
PrimeCare Medical Group
Houston, Texas, 77024, United States
JCCT- Juno NW Houston
Houston, Texas, 77040, United States
Biopharma Informatic_Houston
Houston, Texas, 77043, United States
Northwest Houston Cardiology, P.A.
Houston, Texas, 77070, United States
Endocrine And Psychiatry Center
Houston, Texas, 77095, United States
Prem Internal Med Asso Houston
Katy, Texas, 77493, United States
DCOL Ctr for Clin Res
Longview, Texas, 75605, United States
Texas Inst, Kdny & Endo Disor
Lufkin, Texas, 75904, United States
PRX Research
Mesquite, Texas, 75149, United States
Clinical Advancement Center
San Antonio, Texas, 78212, United States
The IMA Group IMA Clinical Trials of America Inc. CTA
San Antonio, Texas, 78229, United States
Univ Of Texas Hlth Science Cntr
San Antonio, Texas, 78229, United States
VIP Trials
San Antonio, Texas, 78230, United States
NE Clin Res of San Antonio
San Antonio, Texas, 78233, United States
Simcare Medical Research, LLC
Sugar Land, Texas, 77478, United States
Valley Diab. & Endo Comp Ctr
Weslaco, Texas, 78596, United States
Progressive Clinical Research UT
Bountiful, Utah, 84010, United States
Alpine Research Association
Layton, Utah, 84041, United States
Wasatch Clinical Research, LLC
Salt Lake City, Utah, 84107, United States
Carient Heart and Vascular
Manassas, Virginia, 20109, United States
Dominion Medical Associates
Richmond, Virginia, 23219, United States
VA Medical Center_Salem
Salem, Virginia, 24153, United States
Selma Medical Associates
Winchester, Virginia, 22601-3834, United States
Instituto de Investigaciones Clínicas Bahia Blanca
Bahía Blanca, Buenos Aires, B8000, Argentina
CEMEDIC
CABA, Buenos Aires, C1440CFD, Argentina
Dolz Investigacion Clinica
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1048, Argentina
Fundación Respirar
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426, Argentina
Centro de Investigaciones Médicas Mar del Plata
Mar del Plata, Buenos Aires, B7600GNY, Argentina
CIMRO
San Rafael, Mendoza Province, M5602GGS, Argentina
Centro Oncológico de Excelencia (COE)
San Juan, San Juan Province, J5400, Argentina
Fundacion Estudios Clinicos
Rosario, Santa Fe Province, S2000DEJ, Argentina
Nuvexa
Rosario, Santa Fe Province, S2000, Argentina
OMI- Organización Médica de Investigación
Buenos Aires, C1015, Argentina
Hospital Sirio Libanes
Buenos Aires, C1419, Argentina
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
Buenos Aires, C1425AGC, Argentina
CIPREC Arenales
CABA, C1061AAS, Argentina
Centro Médico Viamonte SRL
CABA, C1120AAC, Argentina
CENUDIAB Centro Médico de Nutrición v Diabetes
CABA, C1440AAD, Argentina
Centro Diabetologico Cordoba Dr. Waitman
Córdoba, 5000, Argentina
Centro médico privado Cemaic
Córdoba, X5008, Argentina
CIPADI
Godoy Cruz, M5501ARP, Argentina
Clínica Mayo de Urgencias Médicas Cruz Blanca
San Miguel de Tucumán, T4000IHE, Argentina
CPHosp Manaus Medicina, Ensino e Pesquisa LTDA
Manaus, Amazonas, 69057-088, Brazil
Instituto de Ensino e Pesquisa Clínica do Ceará Ltda
Fortaleza, Ceará, 60135-270, Brazil
CECAP - Centro de Cardiologia Clínica e Pesquisa Dra. Juliana Souza
Brasília, Federal District, 70673-416, Brazil
Instituto de Ciências Farmacêuticas de Estudos e Pesquisas
Aparecida de Goiânia, Goiás, 74935-530, Brazil
Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, Goiás, 74605-020, Brazil
Eurolatino Medical Research Center
Uberlândia, Minas Gerais, 38400-500, Brazil
Centro de Diabetes Curitiba
Curitiba, Paraná, 80810-040, Brazil
Hospital Universitário João de Barros Barreto - UFPA
Belém, Pará, 66073-000, Brazil
Lóbus Centro de Pesquisa Clínica LTDA
Volta Redonda, Rio de Janeiro, 27258-000, Brazil
Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
Bragança Paulista, São Paulo, 12916-542, Brazil
Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, 13060-080, Brazil
i9 Pesquisas Clínicas
Campinas, São Paulo, 13092-133, Brazil
Instituto de Pesquisa Clinica (IPEC)
São Paulo, São Paulo, 01223-001, Brazil
CPQuali Pesquisa Clínica Ltda
São Paulo, São Paulo, 01228-000, Brazil
Instituto do Coração - HCFMUSP
São Paulo, São Paulo, 05403-000, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
Sao Jose Rio Preto, 15090-000, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, 04266-010, Brazil
Medical centre Asclepius OOD
Dupnitsa, Kyustendil, 2600, Bulgaria
Medical Center Diya Med EOOD
Burgas, 8000, Bulgaria
MC Diamedical - 2013 OOD, Dimitrovgrad
Dimitrovgrad, 6400, Bulgaria
Medical Center Viva Feniks OOD
Dobrich, 9300, Bulgaria
AIPSOMCEMD Dr. Velichka Zlatareva EOOD
Plovdiv, 4030, Bulgaria
Medical center Smolyan clinical research OOD
Smolyan, 4700, Bulgaria
Medical centre Vitclinic EOOD
Sofia, 1680, Bulgaria
Prevencia - 2000 - MCOC OOD
Stara Zagora, 6000, Bulgaria
MC Berbatov EOOD, Beli Drin
Yambol, 8600, Bulgaria
Centricity Research Calgary Endocrinology
Calgary, Alberta, T2H 2G4, Canada
University of Alberta_Edmonton
Edmonton, Alberta, T6G 2B7, Canada
CARe Clinic Ltd.
Red Deer, Alberta, T4P 1K4, Canada
Medical Arts Health Research Group_Kelowna_0
Kelowna, British Columbia, V1Y 4N7, Canada
Kelowna Health and Memory Centre Ltd.
Kelowna, British Columbia, V1Y 5A8, Canada
Care Access Cape Breton
Sydney, Nova Scotia, B1M 0A1, Canada
Bluewater Clin Res Group Inc
Sarnia, Ontario, N7T 4X3, Canada
Stouffville Medical Research Institute
Stouffville, Ontario, L4A 1H2, Canada
Centricity Research Toronto
Toronto, Ontario, M4G 3E8, Canada
Centre de Médecine Métabolique de Lanaudière
Terrebonne, Quebec, J6X 4P7, Canada
The Second People's Hospital of Hefei-Endocrinology
Hefei, Anhui, 230012, China
The Second Hospital of Anhui Medical University-Endocrinology
Hefei, Anhui, 230061, China
Chinese Academy of Medical Sciences Fuwai Hospital-Endocrinology
Beijing, Beijing Municipality, 100037, China
Peking University People's Hospital-Endocrinology
Beijing, Beijing Municipality, 100044, China
The Second Affiliated Hospital of Chongqing Medical University-Endocrinology
Chongqing, Chongqing Municipality, 400010, China
Chongqing University Three Gorges Hospital-Endocrinology
Chongqing, Chongqing Municipality, 404199, China
The Second People's Hospital of Shenzhen-Endocrinology
Shenzhen, Guangdong, 518035, China
Cangzhou People's Hospital-Endocrinology
Cangzhou, Hebei, 061000, China
Hebei PetroChina Central Hospital-Endocrinology
Langfang, Hebei, 065099, China
The Second Hospital of Hebei Medical University-Endocrinology
Shijiazhuang, Hebei, 050000, China
The First Hospital of Hebei Medical University-Endocrinology
Shijiazhuang, Hebei, 050023, China
Huaihe Hospital of Henan University-Endocrinology
Kaifeng, Henan, 475000, China
Luoyang First People's Hospital-Endocrinology
Luoyang, Henan, 471002, China
The First Affiliated Hospital of Henan University of Science and Technology-Endocrinology
Luoyang, Henan, 471003, China
The First Affiliated Hospital of Nanyang Medical College-Endocrinology
Nanyang, Henan, 473058, China
The Second Affiliated Hospital of Zhengzhou University-Endocrinology
Zhengzhou, Henan, 450003, China
The First Affiliated Hospital of Zhengzhou University-Endocrinology
Zhengzhou, Henan, 450052, China
Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine)-Endocrinology
Shiyan, Hubei, 442008, China
The First People's Hospital of Changde City-Endocrinology
Changde, Hunan, 415003, China
The First People's Hospital of Changzhou-Endocrinology
Changzhou, Jiangsu, 213004, China
Changzhou No.2 People's Hospital-Endocrinology
Changzhou, Jiangsu, 213164, China
Nanjing First Hospital-Endocriniology
Nanjing, Jiangsu, 210006, China
The Second Affiliated Hospital of Nanjing Medical University-Endocrinology
Nanjing, Jiangsu, 210011, China
Nanjing Jiangning Hospital-Endocrinology
Nanjing, Jiangsu, 211199, China
The Second Affiliated Hospital of Soochow University-Endocrinology
Suzhou, Jiangsu, 215004, China
The Affiliated Hospital of Jiangsu University-Endocrinology
Zhenjiang, Jiangsu, 212001, China
The First Bethune hospital of Jilin University-Endocrinology
Changchun, Jilin, 130061, China
The Second Norman Bethune Hospital of Jilin University-Endocrinology
Jilin City, Jilin, 130041, China
Panjin Liaoyou Gemflower Hospital-Endocrinology
Panjin, Liaoning, 124120, China
Qinghai Provincial People's Hospital-Endocrinology
Xining, Qinghai, 810007, China
Jinan Central Hospital-General Medicine
Jinan, Shandong, 250013, China
Central Hospital of Minhang District, Shanghai-Endocrinology
Shanghai, Shanghai Municipality, 201199, China
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital; Affiliated Hospital of UESTC-Endocrinology
Chengdu, Sichuan, 610071, China
Huzhou Central Hospital-Endocrinology
Huzhou, Zhejiang, 313000, China
EFERTUS healthcare s.r.o.
Brno, 615 00, Czechia
Edumed s.r.o.
Broumov, 550 01, Czechia
Nemocnice Český Krumlov, a.s.
Český Krumlov, 381 01, Czechia
Poliklinika Dolní Břežany
Dolní Břežany, 252 41, Czechia
Medika Hradec Králové s.r.o.
Hradec Králové, 500 02, Czechia
Edumed s.r.o.
Náchod, 547 01, Czechia
MUDr. SRPOVÁ s.r.o.
Ostrava, 700 30, Czechia
Donmed s.r.o.
Ostrava, 710 00, Czechia
Pratia Pardubice a.s.
Pardubice, 530 02, Czechia
MUDr. Jitka Zemanova - diabetologie a interna, s.r.o.
Pilsen, 326 00, Czechia
Medicon a.s.
Prague, 140 00, Czechia
IKEM
Prague, 140 21, Czechia
Diantel s.r.o.
Prague, 17000, Czechia
Medizinisches Versorgungszentrum Jung GbR
Deggingen, 73326, Germany
Praxis am Markt Dr. Becker
Essen, 45355, Germany
MVZ Diabeteszentrum Dr. Tews GmbH
Gelnhausen, 63571, Germany
Diabetes-Zentrum-Wilhelmsburg GbR
Hamburg, 21109, Germany
Diabetes Zentrum Wandsbek Berufsausuebungsgemeinschaft GbR
Hamburg, 22041, Germany
Dr. Milek medikum
Hohenmölsen, 06679, Germany
Praxisgemeinschaft Jerichow
Jerichow, 39319, Germany
Gemeinschaftspraxis Dr. Täschner/Dr. Bonigut
Leipzig, 04249, Germany
Sanos Clinic GmbH Ratingen
Ratingen, 40882, Germany
Evangelismos S.A. - Endocrinology department
Athens, 10676, Greece
251 Air Force General Hospital - Department of Endocrinology & Diabetes
Athens, 115 25, Greece
Laiko General Hospital Of Athens - 1st department of Internal Medicine
Athens, 115 27, Greece
General Hospital Of Athens G Gennimatas - Department of Endocrinology
Athens, 11527, Greece
General Hospital Of Thessaloniki Papageorgiou - 3rd Department of Internal Medicine
Efkarpia, 564 29, Greece
University General Hospital Of Heraklion - Nephrology Department
Heraklion, 71500, Greece
Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
Peristeri, 121 31, Greece
General University Hospital of Patras,Nephrology clinic
Rio, Patra, 26504, Greece
Ippokratio General Hospital Of Thessaloniki - 2nd Propaedeutic Department of Internal Medicine
Thessaloniki, 546 42, Greece
Ippokratio General Hospital Of Thessaloniki - B' Internal Medicine clinic
Thessaloniki, 546 42, Greece
Geniko Nosokomeio Thessalonikis George Papanikolaou - Internal Medicine and Diabetes Department
Thessaloniki, 570 10, Greece
Geniko Nosokomeio Nikaias Peiraia Ag. Panteleimon Geniko Nosokomeio Dytikis Attikis I - Nephrology Department
Νikaia, 184 54, Greece
Endolife Specialty Hospitals
Guntur, Andhra Pradesh, 522001, India
All India Institute of Medical Sciences (AIIMS), Raipur
Raipur, Chhattisgarh, 492099, India
Nirmal Hospital Pvt. Ltd.
Surat, Gujarat, 395001, India
SSG Hospital, Baroda
Vadodara, Gujarat, 390001, India
Life Care Hospital and Research Centre
Bangalore, Karnataka, 560092, India
Amrita Institute Of Medical Sciences & Research Centre
Kochi, Kerala, 682041, India
Government Medical College, Kozhikode
Kozhikode, Kerala, 673008, India
TOTALL Diabetes Hormone Institute
Indore, Madhya Pradesh, 452010, India
BSES MG hospital
Mumbai, Maharashtra, 400058, India
Sunil's Diabetes Care n' Research Centre Pvt Ltd
Nagpur, Maharashtra, 440010, India
Chellaram Diabetes Institute
Pune, Maharashtra, 411021, India
Ashirwad Hospital and Research Centre
Thane, Maharashtra, 421004, India
All India Institute of Medical Sciences (AIIMS), Bhubaneswar
Bhubaneswar, Odisha, 751019, India
Deep Healthcare Private Limited.
Ludhiana, Punjab, 141002, India
Diabetes, Thyroid and Endocrine Centre
Jaipur, Rajasthan, 302006, India
KG Hospital and PG Medical Institute & Research Centre
Coimbatore, Tamil Nadu, 641018, India
Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, 632004, India
Osmania General Hospital_Hyderabad
Hyderabad, Telangana, 500012, India
NIZAM'S Institute of Medical Sciences
Hyderabad, Telangana, 500082, India
SMS Hospital
Jaipur, 302004, India
All India Institute of Medical Sciences (AIIMS)
New Delhi, 110029, India
Università degli studi G. D'Annunzio di Chieti - CAST - Centro Ricera Clinica (CRC)
Chieti, Abruzzo, 66100, Italy
AOU Renato Dulbecco - Unità Operativa Complessa Medicina Interna
Catanzaro, Calabria, 88100, Italy
AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Endocrinologia Diabetologia e Andrologia
Naples, Campania, 80131, Italy
AUSL Romagna - Medicine Specialistiche Ravenna - UO Servizio di Diabetologia di Ravenna
Ravenna, Emilia-Romagna, 48121, Italy
Polo Ospedaliero di Chiavari - S.S.D. Diabetologia e Malattia Metaboliche
Chiavari, Liguria, 16043, Italy
Ospedale San Raffaele S.r.l. - Medicina Generale Indirizzo Diabetologico ed Endocrino-Metabolico
Milan, Lombardy, 20132, Italy
Policlinico Umberto I Seconda Clinica Medica
Roma, RM, 00161, Italy
AUSL Toscana Nord Ovest - Cittadella della Salute Campo di Marte - Diabetologia Lucca e Valle del Serchio
Lucca, Tuscany, 55100, Italy
ASST Santi Paolo e Carlo - Ospedale San Paolo - Diabetologia
Milan, 20142, Italy
Diseño y Planeación en Investigación Médica S.C.
Guadalajara, Jalisco, 44600, Mexico
Instituto Jalisciense de Investigación en Diabetes y Obesidad
Guadalajara, Jalisco, 44600, Mexico
Centro de Investigacion Clinica Endocrinologica de Jalisco
Guadalajara, Jalisco, 44670, Mexico
Instituto Nacional de Ciencias Médicas y Nutrición
Tlalpan, Mexico City, 14080, Mexico
Alliance CEINV Salud S.A. de C.V.
Monterrey, Nuevo León, 64020, Mexico
Investigación Médica Sonora S.C.
Hermosillo, Sonora, 83280, Mexico
Centro de Estudios de Investigación Metabólicos y Cardio
Ciudad Madero, Tamaulipas, 89440, Mexico
SIYODE S.A. de C.V. Unimeden
Ciudad Madero, Tamaulipas, 89450, Mexico
Centro de Desarrollo Biomédico S.C.P.
Merida Centro, Yucatán, 97070, Mexico
Medical Care and Research S. A de C.V
Mérida, Yucatán, 97070, Mexico
Zana-Med Medical Group Sp. z o.o.
Lublin, Lublin Voivodeship, 20-601, Poland
NZOZ Vita-Diabetica Malgorzata Buraczyk
Bialystok, Podlaskie Voivodeship, 15-879, Poland
M2M Med. Badania Sp. z o.o.
Chorzów, Silesian Voivodeship, 41-500, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15-269, Poland
Osteo-Medic s.c. A. Racewicz, J. Supronik
Bialystok, 15-351, Poland
Kresmed Sp. z o. o.
Bialystok, 15-481, Poland
Zespol Opieki Zdrowotnej w Boleslawcu
Bolesławiec, 59-700, Poland
Diab Serwis Popenda Spółka Jawna
Chorzów, 41-516, Poland
Gyncentrum Sp. z o. o.
Katowice, 40-600, Poland
Centrum Medyczne MBB-MED Marta Blach-Burek
Libiąż, 32-590, Poland
Gabinet Lekarski Malgorzata Saryusz-Wolska
Lodz, 90-132, Poland
Amicare Sp. z o.o. S.K.
Lodz, 91-495, Poland
Velocity Nova Sp. z o.o.
Lublin, 20-362, Poland
Etyka Osrodek Badan Klinicznych Tomasz Pesta S.K.A.
Olsztyn, 10-117, Poland
Irmed Klimkiewicz Rudziewicz-Kowalska sp. j.
Piotrkow Trybunalski, 97-300, Poland
Centrum Zdrowia Metabolicznego Paweł Bogdański
Poznan, 60-589, Poland
Maciej Wiza Gaja Poradnie Lekarskie
Poznan, 61-251, Poland
Velocity Nova Sp. z o.o.
Puławy, 24-100, Poland
Centrum Medyczne Medyk Sp.zo.o. Sp.k.
Rzeszów, 35-055, Poland
Medicover Integrated Clinical Services Sp. z o.o.
Torun, 87-100, Poland
Szpital Czerniakowski Sp. z o.o.
Warsaw, 00-739, Poland
PANSTWOWY INSTYTUT MEDYCZNY MSWiA
Warsaw, 02-507, Poland
Regionalna Poradnia Diabetologiczna-Zytkiewicz-Jaruga, Stasinska Spolka Partnerska Lekarzy
Wroclaw, 50-127, Poland
Velocity Nova Sp. z o.o.
Zamość, 22-400, Poland
Prywatna Praktyka Lekarska Anna Chudoba
Żyrardów, 96-300, Poland
CHUAC_Endocrinología
A Coruña, 15006, Spain
Hosp. Vall d'Hebrón_Endocrinología
Barcelona, 08035, Spain
Clinic Barcelona_Endocrinología
Barcelona, 08036, Spain
Hospital de Mostoles_Endocrinología
Móstoles, 28935, Spain
H Virgen del Camino_Sanlúcar_Medicina Interna
Sanlúcar de Barrameda, 11540, Spain
CHUS_Endocrinología
Santiago de Compostela, 15706, Spain
Hospital General de Segovia_Endocrinología
Segovia, 40002, Spain
Hospital General de Valencia_Endocrinología
Valencia, 46014, Spain
Erciyes Üniversitesi Hastanesi - Nefroloji
Kayseri, Melikgazi, 38039, Turkey (Türkiye)
Adana Şehir Eğitim ve Araştırma Hastanesi
Adana, 01060, Turkey (Türkiye)
Başkent Üniversitesi Adana Dr. Turgut Noyan Uygulama ve Araştırma Merkezi -Endokrinoloji
Adana /yüreği̇r, 01240, Turkey (Türkiye)
Sakarya Egitim ve Arastirma Hastanesi-Nefroloji
Adapazarı/Turkiye, 54100, Turkey (Türkiye)
Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Nefroloji
Afyonkarahisar, 03200, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-Dahiliye
Ankara, 06800, Turkey (Türkiye)
Gaziantep Üniversitesi Hastanesi- Endokrinoloji
Gaziantep, 27070, Turkey (Türkiye)
Göztepe Prof. Dr.Süleyman Yalçın Şehir Hastanesi- Dahiliye
Istanbul, 34722, Turkey (Türkiye)
Ege Üniversitesi Tip Fakultesi Hastanesi - Nefroloji
Izmir, 35100, Turkey (Türkiye)
Erciyes Üniversitesi Hastanesi- Kardiyoloji
Kayseri, 38039, Turkey (Türkiye)
Kocaeli Üniversitesi Araştıma ve Uygulama Hastanesi - Nefroloji
Kocaeli, 41380, Turkey (Türkiye)
Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Endokrinoloji
Nilüfer/Bursa, 16140, Turkey (Türkiye)
Eskişehir Şehir Hastanesi- Kardiyoloji
Odunpazarı /Eskişehir, 26080, Turkey (Türkiye)
Sivas Cumhuriyet Üniversitesi Hastanesi -Endokrinoloji
Sivas, 58140, Turkey (Türkiye)
Dicle Üniversitesi Tıp Fakültesi Sağlık Ve Araştırma Hastanesi- Nefroloji
Sur / Diyarbakır, 21280, Turkey (Türkiye)
North Coast Medical Ltd
Newquay, Cornwall, TR7 1RU, United Kingdom
Yeovil Hospital
Yeovil, Somerset, BA21 4AT, United Kingdom
Clifton Medical Centre
Rotherham, South Yorkshire, S65 1DA, United Kingdom
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
University Hospital Coventry - WISDEM Centre
Coventry, CV2 2DX, United Kingdom
Hull Royal Infirmary - Diabetes
Hull, HU3 2JZ, United Kingdom
Ipswich Hospital - Diabetes
Ipswich, IP4 5PD, United Kingdom
Altnagelvin Area Hospital
Londonderry, BT47 6SB, United Kingdom
Joint Clinical Research Facility - Swansea
Swansea, SA2 8PP, United Kingdom
Egremont Medical Centre
Wallasey, CH44 8AT, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 26, 2026
First Posted
September 1, 2026
Study Start
August 24, 2026
Primary Completion (Estimated)
July 31, 2028
Study Completion (Estimated)
September 20, 2028
Last Updated
September 1, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will share
According to the Novo Nordisk disclosure commitment on novonordisktrials.com