Menthol Chewing Gum After Laparoscopic Colorectal Surgery

NCT07796529 | Completed

• 1 other identifier: MCG-CRC-2024-01
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial was conducted to evaluate the effect of menthol chewing gum on postoperative nausea and vomiting, bowel function, and recovery in patients undergoing laparoscopic colorectal surgery. A total of 50 patients were randomly assigned to an intervention group (n=25) or a control group (n=25). Participants in the intervention group received menthol chewing gum in addition to standard postoperative care, while participants in the control group received standard postoperative care only. Nausea, bowel function, and postoperative recovery were assessed during the first three postoperative days.

Conditions

Postoperative Nausea and Vomiting; Bowel Functions; Postoperative Recovery

Keywords

Menthol Chewing Gum; Chewing Gum; Laparoscopic Colorectal Surgery; Postoperative Nausea and Vomiting; Bowel Function; Surgical Recovery; Nonpharmacological Intervention

Outcome Measures

Primary Outcomes (1)

• Postoperative Nausea and Vomiting Frequency

  The frequency of postoperative nausea and vomiting was recorded for each participant during the first three postoperative days. Higher values indicate a greater frequency of nausea and vomiting.

  Postoperative days 1, 2, and 3

Secondary Outcomes (1)

• Postoperative Gas Passage Frequency

  Postoperative days 1, 2, and 3

Other Outcomes (2)

• Postoperative Defecation Frequency

  [Time Frame: Postoperative days 1, 2, and 3]

• Postoperative Recovery Status

  Postoperative days 1, 2, and 3

Study Arms (2)

1

EXPERIMENTAL

Menthol Chewing Gum Group

Behavioral: Menthol Chewing Gum

2

NO INTERVENTION

Control Group

Interventions

Menthol Chewing Gum BEHAVIORAL

Participants chewed menthol gum for 30 minutes, followed by a second 30-minute chewing session three hours later. This intervention was repeated on postoperative days 1, 2, and 3 in addition to standard postoperative care.

1

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 18-60 years
• Willing to participate in the study
• At least literate
• Able to communicate without cognitive, sensory, or verbal impairment
• No diagnosed psychiatric disorder
• No vertigo
• Undergoing elective surgery
• Not using sedative, anxiolytic, or similar medications
• Able to speak Turkish
• Able to chew gum
• No allergy to menthol or mint
• No history of jaw or oral surgery

You may not qualify if:

• Absence of teeth
• Unwilling to chew gum

Sponsors & Collaborators

• Sennur Kula Şahin: lead

Study Sites (1)

Istinye University Medical Park Gaziosmanpasa Hospital

Istanbul, Istanbul, 34010, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assoc.Prof

Model Details: Participants were randomly assigned in a 1:1 ratio to either the menthol chewing gum group or the standard care control group.

Study Record Dates

• First Submitted: August 26, 2026
• First Posted: September 1, 2026
• Study Start: January 15, 2024
• Primary Completion: April 25, 2024
• Study Completion: April 25, 2024
• Last Updated: September 1, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)