NCT07796269

Brief Summary

Patients presenting to the University of Nebraska Medical Center College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid (GCF) and saliva sampling and a blood draw. Following atraumatic tooth extraction, the subjects will be reevaluated for healing at 1, 2-weeks and 3 months. At each appointment, GCF, saliva and wound fluid (WF) will be collected and at 3 months a second xray will be taken.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
72

participants targeted

Target at P50-P75 for all trials

Timeline
49mo left

Started Nov 2026

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 27, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 1, 2026

Completed
2 months until next milestone

Study Start

First participant enrolled

November 1, 2026

Expected
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2028

2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2030

Last Updated

September 14, 2026

Status Verified

August 1, 2026

Enrollment Period

2 years

First QC Date

August 27, 2026

Last Update Submit

September 10, 2026

Conditions

Wound Healing

Keywords

extractionelderly

Outcome Measures

Primary Outcomes (1)

  • Amount of Interleukin-1 beta (IL1-B) in gingival crevicular at baseline

    Measurement of IL1B in GCF

    Baseline

Secondary Outcomes (1)

  • Bone Density

    3 months

Interventions

tooth extractionPROCEDURE

posterior tooth extraction

Eligibility Criteria

Age65 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Study population will be made of patients at the UNMC College of Dentistry requiring posterior extraction, aged 65-80.

You may qualify if:

  • needs posterior tooth extracted
  • no systemic conditions or meds affecting wound healing
  • non-smoker

You may not qualify if:

  • systemic conditions or meds known to affect wound healing
  • smokers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Nebraska Medical Center College of Dentistry

Lincoln, Nebraska, 68583, United States

Location

Related Publications (1)

  • Dignam P, Elshafey M, Jeganathan A, Foo M, Park JS, Ratnaweera M. Prevalence and Factors Influencing Post-Operative Complications following Tooth Extraction: A Narrative Review. Int J Dent. 2024;2024:7712829. Epub 20240509. doi: 10.1155/2024/7712829. PubMed PMID: 38756385; PMCID: PMC11098612. 2. Khalid KA, Nawi AFM, Zulkifli N, Barkat MA, Hadi H. Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. Life (Basel). 2022;12(12). Epub 20221219. doi: 10.3390/life12122142. PubMed PMID: 36556508; PMCID: PMC9784880. 3. Martin P, Pardo-Pastor C, Jenkins RG, Rosenblatt J. Imperfect wound healing sets the stage for chronic diseases. Science. 2024;386(6726):eadp2974. Epub 20241206. doi: 10.1126/science.adp2974. PubMed PMID: 39636982. 4. Amler MH. Age factor in human alveolar bone repair. J Oral Implantol. 1993;19(2):138-42. PubMed PMID: 8246300. 5. Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018;97(13):1424-30. Epub 20180803. doi: 10.1177/0022034518792567. PubMed PMID: 30075090; PMCID: PMC6854267. 6. Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S. Current Knowledge on the Healing of the Extraction Socket: A Narrative Review. Bioengineering (Basel). 2023;10(10). Epub 20230929. doi: 10.3390/bioengineering10101145. PubMed PMID: 37892875; PMCID: PMC10604628. 7. Sims NA. Influences of the IL-6 cytokine family on bone structure and function. Cytokine. 2021;146:155655. Epub 20210728. doi: 10.1016/j.cyto.2021.155655. PubMed PMID: 34332274. 8. Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and Chemokines in Periodontitis. Eur J Dent. 2020;14(3):483-95. Epub 20200623. doi: 10.1055/s-0040-1712718. PubMed PMID: 32575137; PMCID: PMC7440949. 9. Razavi P, Rezaee SA, Akhondian S, Asgari N, Fatemi K, Mohajertehran F. Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of

    BACKGROUND

MeSH Terms

Interventions

Tooth Extraction

Intervention Hierarchy (Ancestors)

Oral Surgical ProceduresSurgical Procedures, OperativeDentistry

Central Study Contacts

Amy Killeen, DDS, MS

CONTACT

4024727848akilleen@unmc.edu

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 27, 2026

First Posted

September 1, 2026

Study Start (Estimated)

November 1, 2026

Primary Completion (Estimated)

November 1, 2028

Study Completion (Estimated)

November 1, 2030

Last Updated

September 14, 2026

Record last verified: 2026-08

Data Sharing

IPD Sharing
Will not share

Locations

US(1)