Modifiable Factors Affecting Racial Disparities in Kidney Donation

NCT07793877 | Completed

• 1 other identifier: PRO00033546
• Study Type: observational
• Target: 2,332
• Locations: 0 countries
• Sites: N/A

Brief Summary

While many people offer to be evaluated at transplant centers as potential living donors to donate one kidney to someone they know, few ultimately donate. Racial/ethnic minorities are less likely to become living donors. This study examines potentially modifiable factors affecting living donation in a large cohort of potential living donors from different transplant centers who are White, Black, Hispanic, and Asian. Investigators are examining ways to intervene with potential living donors to help overcome racial disparities and increase the number of people who ultimately donate.

Conditions

Kidney Transplant Donor

Outcome Measures

Primary Outcomes (1)

• How Changeable Factors Affect Completion of Living Donor Evaluation for Black, Hispanic, and White Volunteers

  Metrics of interest include whether donor volunteers present for evaluation, defined as attending the first in-person visit, and whether they complete the donor evaluation, defined as finishing all required steps except donation. Both outcomes are measured as yes or no. Investigators will use logistic regression to examine differences in the likelihood of presentation and completion among Black, Hispanic, and White donors. Initial analyses will examine the relationship between race and each outcome separately. Race will then be included in multivariable models, with survey-based factors added by category. Changes in the size or significance of race effects after adjustment will be evaluated. If the association between race and evaluation outcomes is reduced after accounting for specific modifiable factors, these factors may represent potential targets for future interventions.

  From onset of evaluation to the outcomes at 12 months

Secondary Outcomes (1)

• How Changeable Factors Influence Whether Living Donors Go on to Donate, Including Through Paired Exchange

  From the onset of evaluation until the date of first documented live kidney donation, assessed up to 18 months

Study Arms (1)

Living Donor Volunteers

Individuals interested in donating a live kidney

Other: Not applicable- observational study

Interventions

Not applicable- observational study OTHER

Potential living donors who presented for evaluation at 5 transplant centers were invited to participate in an exploratory study assessing their motivations for donating, their living donation knowledge, their financial barriers to donating, and their educational preparedness. All potential living donors completed Survey 1, and a subset of individuals who completed living donor evaluation, completed Survey 2. After 12 months, chart review for all individuals who completed Survey 1 occurred to determine whether they received a transplant or not, and if not what reasons they were ruled out. No data collection took place at Houston Methodist.

Living Donor Volunteers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

"Donor volunteers" defined as persons who contacted SBMC or UCLA to request an information packet regarding live kidney donation and then completed and returned a Living Donor Referral Form (included in the packet). Persons who received an information packet but failed to return the Living Donor Referral Form were not considered donor volunteers and were not eligible for the cohort study.

You may qualify if:

• Live kidney donor volunteer

You may not qualify if:

• Limited proficiency in both English and Spanish
• Required assistance to fill out the study questionnaire
• Non-directed donors (altruistic donors who lack a specific intended recipient)
• Failure to complete baseline questionnaire

Sponsors & Collaborators

• The Methodist Hospital Research Institute: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 27, 2026
• First Posted: August 31, 2026
• Study Start: February 4, 2022
• Primary Completion: November 30, 2025
• Study Completion: November 30, 2025
• Last Updated: August 31, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share