Understanding Information Preferences, Risk Perceptions, and Tradeoffs When Making Decisions About Multi-cancer Early Detection Tests
Investigating Information Preferences, Risk Perceptions, and Tradeoffs in Multi-Cancer Early Detection Decisions: A Randomized Vignette Trial
2 other identifiers
interventional
3,000
1 country
1
Brief Summary
The goal of this clinical trial is to learn what people's informational preferences and risk perceptions are in regards to the use of multi-cancer early detection (MCED) tests. Participants will be asked to review three informational factors about MCED tests and complete a survey about their intentions to use an MCED test. Some participants will also be asked to complete an interview.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2027
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 14, 2026
CompletedFirst Posted
Study publicly available on registry
August 28, 2026
CompletedStudy Start
First participant enrolled
September 1, 2027
ExpectedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2028
Study Completion
Last participant's last visit for all outcomes
July 1, 2029
August 28, 2026
August 1, 2026
10 months
August 14, 2026
August 26, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Decisional Conflict
A validated 10-item scale scored 0-100 that assesses decisional conflict using a 3-point Likert for each item; Includes 4 subscales: informed, uncertainty, values clarity, and support. The full scale will be administered after the third vignette is presented (Time 3).
24 hours
Secondary Outcomes (3)
Screening Intentions
24 hours
Informed Subscale of the Decisional Conflict Scale
24 hours
Uncertainty Subscale of the Decisional Conflict Scale
24 hours
Study Arms (8)
Arm 1: High, High, High
EXPERIMENTALArm 2: High, High, Low
EXPERIMENTALArm 3: High, Low, Low
EXPERIMENTALArm 4: High, Low, High
EXPERIMENTALArm 5: Low, High, High
EXPERIMENTALArm 6: Low, Low, High
EXPERIMENTALArm 7: Low, High, Low
EXPERIMENTALArm 8: Low, Low, Low
EXPERIMENTALInterventions
The test performance data presented in the vignette will focus on established evidentiary standards for the evaluation of screening tests: Sensitivity, specificity, positive and negative predictive values, and the ability of tests to find specific cancers and more early-stage cancers. The high numerical detail condition will utilize these numbers and present them according to the decision aid criteria for presenting treatment option data and addressing health literacy.
The low numerical detail condition will describe the potential for false positives and use descriptions to denote qualitatively performance (high, acceptable, moderate, low). The test performance data presented in the vignette will focus on established evidentiary standards for the evaluation of screening tests: Sensitivity, specificity, positive and negative predictive values, and the ability of tests to find specific cancers and more early-stage cancers.
The high numerical data will use diagnostic workup data from the most up-to-date findings at the time of survey fielding. Data will be presented on the number of positive tests, follow up included (type and properties of tests), likelihood of receiving each type of test upon a positive findings, and data on median length of time to diagnostic resolution for both true positives and false positives.
The low numerical detail condition will describe the possibility of further testing (more blood tests, imaging, and/or procedures) that may be required if the multi-cancer early detection (MCED) test has a positive finding, in line with prior studies communicating about MCED test workup.
Cost estimates will include insurance and out of pocket costs associated with various pathways of diagnostic workup. The investigators will use test cost estimates based on market rates and insurance coverage mandates at the time of fielding the survey. The high numerical data condition will provide precise estimates conditioned on level of workup and insurance coverage. As above, the final content will be informed by new information that may be gleaned from ongoing studies.
The low numerical data will provide broad ranges of diagnostic costs, indicating what costs are covered by insurance, and which are not.
Eligibility Criteria
You may qualify if:
- Aged 40-74
- Speak English or Spanish
You may not qualify if:
- Prior diagnosis of cancer (with the exception of non-melanoma skin cancers)
- Previous use of a Multi-Cancer Early Detection (MCED) test.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Trustees of Dartmouth Collegelead
- National Cancer Institute (NCI)collaborator
Study Sites (1)
Dartmouth College
Lebanon, New Hampshire, 03756, United States
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor of Health Policy and Clinical Practice
Study Record Dates
First Submitted
August 14, 2026
First Posted
August 28, 2026
Study Start (Estimated)
September 1, 2027
Primary Completion (Estimated)
July 1, 2028
Study Completion (Estimated)
July 1, 2029
Last Updated
August 28, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, ANALYTIC CODE
- Time Frame
- Data will be made available no later than time of an associated publication or end of the performance period, whichever comes first. Data will be available for 5 years from the end of the study period.
- Access Criteria
- Requests for access to the data will be managed by the repository. Requests will indicate intended use of the data, protections to be put in place to ensure secure data transfer, and to formulate a data use agreement, if applicable.
Based on ethical considerations related to the protection of human subjects, the following data produced during the project will be preserved and shared: * Survey responses * Survey weights * Qualitative interview data, deidentified and without any participant identifiers beyond assigned study group, state, and limited sociodemographic characteristics The investigators will seek to share as much data as possible while maintaining a de-identified dataset without protected health information. Thus, the final shared data set will not include geographic subdivisions smaller than the state level, dates, birth dates, contact information, or other identification numbers. Data available to be shared will be archived in the University of Michigan ICPSR data repository, which was chosen for its focus on social and behavioral data that align with the nature of data collected in this project.