Diabetes and Permanent Disabilities

NCT07788235 | Completed

• 1 other identifier: BTL0001-2026
• Study Type: observational
• Target: 450,000
• Locations: 1 country
• Sites: 2

Brief Summary

This study examines permanent disability related to diabetes using routinely collected data from the National Insurance Institute of Israel. The study will evaluate how often diabetes is recorded among people who have been granted permanent disability and whether the frequency and severity of diabetes-related disability differ by geographic area and over time. It will also examine the distribution of disability according to the statutory level of diabetes-related impairment. Data from 2020 through 2025 will be analyzed. The study is observational and retrospective, meaning that it uses information that has already been collected for administrative purposes. No participants will receive an intervention, medication, or additional medical examination as part of the study. The main goals are to describe national and regional patterns of diabetes-related permanent disability, identify changes over time, and determine whether meaningful geographic differences exist. The findings may help improve understanding of the burden of diabetes-related disability and support future health care, prevention, rehabilitation, and social-policy planning.

Conditions

Diabetes; Diabetes (Insulin-requiring, Type 1 or Type 2)

Outcome Measures

Primary Outcomes (1)

• Diabetes co-morbidities

  Proportion of permanent-disability records in which diabetes mellitus is recognized as a condition contributing to the permanent disability determination, overall and by geographic district.

  8 years

Secondary Outcomes (1)

• diabetes-related permanent disability severity

  8 years

Study Arms (1)

Diabetes and co-morbidities

All individuals with a recognized permanent disability recorded by the National Insurance Institute of Israel between 2020 and 2025 will constitute the study population. Within this population, records in which diabetes mellitus is documented as a condition contributing to the permanent disability determination will be identified and analyzed. Diabetes-related disability will be classified according to the applicable statutory impairment categories. Geographic and temporal patterns will be evaluated across administrative districts and study years. This is a retrospective observational study based on routinely collected administrative data; no intervention, treatment, or additional clinical assessment will be performed as part of the study.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Temporary disability determinations without recognition of permanent disability. Records outside the predefined study period. Records with insufficient or incomplete information for classification of diabetes-related disability or geographic district. Duplicate administrative records, when identified.

You may qualify if:

• Individuals with a permanent disability determination recorded by the National Insurance Institute of Israel between January 1, 2020 and December 31, 2025.
• Records containing sufficient information to determine whether diabetes mellitus contributed to the permanent disability assessment.
• For diabetes-specific analyses, individuals with diabetes mellitus documented as a recognized condition contributing to permanent disability.

Sponsors & Collaborators

• Assuta Medical Center: lead

Study Sites (2)

Assuta Medical Center

Rishon LeZiyyon, 7526557, Israel

Location

Israel National Insurance Institute

Rishon LeZiyyon, 7526557, Israel

Location

Related Publications (5)

• Herquelot E, Gueguen A, Bonenfant S, Dray-Spira R. Impact of diabetes on work cessation: data from the GAZEL cohort study. Diabetes Care. 2011 Jun;34(6):1344-9. doi: 10.2337/dc10-2225. Epub 2011 May 11.

  PMID: 21562323 BACKGROUND

• Nexo MA, Pedersen J, Cleal B, Bjorner JB. Increased risk of long-term sickness absence, lower rate of return to work and higher risk of disability pension among people with type 1 and type 2 diabetes mellitus: a Danish retrospective cohort study with up to 17 years' follow-up. Diabet Med. 2020 Nov;37(11):1861-1865. doi: 10.1111/dme.14203. Epub 2019 Dec 17.

  PMID: 31811666 BACKGROUND

• Ervasti J, Virtanen M, Pentti J, Lallukka T, Tinghog P, Kjeldgard L, Mittendorfer-Rutz E, Alexanderson K. Work disability before and after diabetes diagnosis: a nationwide population-based register study in Sweden. Am J Public Health. 2015 Jun;105(6):e22-9. doi: 10.2105/AJPH.2015.302646. Epub 2015 Apr 16.

  PMID: 25879142 BACKGROUND

• Breton MC, Guenette L, Amiche MA, Kayibanda JF, Gregoire JP, Moisan J. Burden of diabetes on the ability to work: a systematic review. Diabetes Care. 2013 Mar;36(3):740-9. doi: 10.2337/dc12-0354. No abstract available.

  PMID: 23431092 BACKGROUND

• Wong E, Backholer K, Gearon E, Harding J, Freak-Poli R, Stevenson C, Peeters A. Diabetes and risk of physical disability in adults: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2013 Oct;1(2):106-14. doi: 10.1016/S2213-8587(13)70046-9. Epub 2013 Jul 24.

  PMID: 24622316 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medicine doctor

Study Record Dates

• First Submitted: August 22, 2026
• First Posted: August 26, 2026
• Study Start: January 1, 2018
• Primary Completion: December 31, 2025
• Study Completion: January 31, 2026
• Last Updated: August 26, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

IL (2)