Intraoperative Glycemic Variability and Infectious Complications After Liver Transplantation

NCT07786857 | Not Yet Recruiting

• 1 other identifier: AKBE/192/2026
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate whether intraoperative glycemic variability (GV) is independently associated with the risk of infectious complications within 30 days after elective liver transplantation. This is an observational study with no intervention beyond standard perioperative care. Glycemic and clinical outcome data will be obtained from routinely collected medical records of patients undergoing liver transplantation at the 2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw.

Conditions

Liver Transplantation (LT)

Keywords

liver transplantation; glycemic variability; postoperative infections; surgical site infection

Outcome Measures

Primary Outcomes (1)

• Occurrence of at least one infectious complication within 30 days after liver transplantation

  Binary outcome (yes/no), including: pneumonia (clinical, radiological, and microbiological criteria), urinary tract infection (clinical symptoms + positive urine culture), surgical site infection per CDC criteria, sepsis/septic shock per Sepsis-3 criteria.

  30 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients undergoing liver transplantation at the 2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw.

You may qualify if:

• Age over 18 years
• Elective orthotopic liver transplantation

You may not qualify if:

• Liver retransplantation
• multi-organ transplantation
• Urgent/emergency transplantation
• Active infection under antibiotic treatment at the time of surgery
• Preoperative systemic inflammatory response syndrome (SIRS)
• Incomplete intraoperative glycemic data
• Pregnancy
• Participation in another interventional study that could affect glycemic control or infection risk

Sponsors & Collaborators

• Medical University of Warsaw: lead

Study Sites (1)

Medical University of Warsaw

Warsaw, Poland

Location

MeSH Terms

Conditions

Surgical Wound Infection

Condition Hierarchy (Ancestors)

Wound Infection; Infections; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Paula Dudek, MD

CONTACT

+225992002; paula.dudek@wum.edu.pl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 27, 2026
• First Posted: August 26, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): July 30, 2027
• Study Completion (Estimated): July 30, 2027
• Last Updated: August 26, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)