Knee Cartilage Repair Registry
C-SHORE
Cartilage Repair Study of Health Outcomes and Real-world Evidence (C-SHORE)
1 other identifier
observational
1,000
1 country
3
Brief Summary
This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage. Information will be collected from patients undergoing knee surgery for cartilage damage and entered into a large database that reflects routine clinical practice ("real-world" data). The data collected will be used to support future research and improve understanding of treatment outcomes for knee cartilage repair.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2026
Longer than P75 for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 21, 2026
CompletedFirst Posted
Study publicly available on registry
August 25, 2026
CompletedStudy Start
First participant enrolled
September 30, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2034
Study Completion
Last participant's last visit for all outcomes
March 31, 2034
August 25, 2026
June 1, 2026
7.5 years
August 21, 2026
August 21, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score change from Baseline to 24-months
The IKDC Subjective Knee Evaluation Form assesses the subject's opinion of their knee across 3 domains: symptoms (7 items), sports activity (2 items), and knee function (2 items; note: 'function prior to knee injury' is not included in the overall score). Responses vary for each item. The sum of all items is converted to a scale of 0 to 100, where 100 represents no limitation with activities \& absence of symptoms (i.e., the best outcome) and 0 represents the worst outcome.
Baseline and 24 months
Study Arms (2)
Marketed Product - MP01
Participants who are having knee cartilage surgery with Marketed Product - MP01
Other Knee Cartilage Procedures
Participants who are having knee cartilage surgery with a procedure other than using Marketed Product - MP01
Interventions
Marketed Product - MP01 is a medical device used in the treatment of knee-joint surface lesions.
Any other surgical procedures used in the treatment of knee-joint surface lesions that fall within the Marketed Product - MP01 on label indication.
Eligibility Criteria
Participants undergoing routine knee cartilage repair
You may qualify if:
- Prospective Subjects
- Provides written informed consent.
- Is eighteen (18) years of age or older at time of consent and considered skeletally mature in the opinion of the investigator.
- Scheduled to undergo knee cartilage surgery with the Marketed Product-MP01 OR other knee cartilage repair surgery.
- For subjects having other knee cartilage repair surgery:
- \- Falls within Marketed Product-MP01 on label indication: Knee chondral or osteochondral lesions (ICRS grade III and above, 1-7cm2) in patients with or without mild-moderate knee osteoarthritis (K/L 0-3).
- Has an electronic device and is willing and able to use the device to complete the 'Electronic Clinical Outcomes Assessment' (eCOA).
- Willing and able to complete all requested questionnaires.
- Able to follow instructions and deemed capable of completing registry protocol requirements.
- Retrospective/Prospective Subjects
- Provides written informed consent.
- Was eighteen (18) years of age or older at time of surgery and considered skeletally mature at that time in the opinion of the investigator.
- Underwent knee cartilage repair surgery with the Marketed Product-MP01 within the last 2-years.
- Has an electronic device and is willing and able to use the device to complete the eCOA.
- Willing and able to complete all requested questionnaires.
- +2 more criteria
You may not qualify if:
- History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate/coral derivatives.
- Is actively participating in a cartilage repair clinical trial.
- For subjects having other knee cartilage repair surgery:
- \- Treatment will be on patellar lesion(s).
- Has participated previously in this registry (with the index or contralateral knee).
- Meets the definition of a Vulnerable Subject per ISO 14155 Section 3.56.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
CAO Research Foundation
Washington D.C., District of Columbia, 20036, United States
The Orthopaedic Research Foundation, Inc.
Indianapolis, Indiana, 46278, United States
Oklahoma Sports Science and Orthopedics
Oklahoma City, Oklahoma, 73114, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Nick DePhillipo, PhD, MBA, ATC
Smith & Nephew, Inc.
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Target Duration
- 5 Years
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 21, 2026
First Posted
August 25, 2026
Study Start (Estimated)
September 30, 2026
Primary Completion (Estimated)
March 31, 2034
Study Completion (Estimated)
March 31, 2034
Last Updated
August 25, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will not share