Biochemical Factors in Patients With and Without Bruxism

NCT07783685 | Completed

• 1 other identifier: AYBU-2023-68
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This observational case-control study aimed to compare biochemical factors related to calcium metabolism between adults with and without bruxism. Participants were classified into bruxism and control groups based on self-reported bruxism behaviors assessed using the BRUX Scale together with standardized clinical examination findings. Serum vitamin D, parathyroid hormone (PTH), calcium, albumin, and albumin-corrected calcium levels were evaluated and compared between the two groups. The study aimed to determine whether these biochemical parameters differ between individuals with and without bruxism and to provide further insight into their potential relationship with bruxism

Conditions

Bruxism

Keywords

Bruxism; vitamin D; Parathyroid hormone; Calcium; Albumin

Outcome Measures

Primary Outcomes (1)

• Serum Vitamin D,calcium,albumin and PTH level

  Serum 25-hydroxyvitamin D \[25(OH)D\], calcium, PTH and albumin levels were obtained from available laboratory records and compared between participants with and without bruxism.

  Within 6 months before study assessment

Study Arms (2)

Bruxism Group

Participants who met the predefined criteria for bruxism based on self-reported bruxism behaviors assessed using the BRUX Scale and standardized clinical examination findings

Control Grup

Participants who did not meet the predefined criteria for bruxism and were matched to the bruxism group according to age and sex.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of adults evaluated at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara Yildirim Beyazit University. Eligible participants with suspected bruxism were assessed using self-reported bruxism behaviors and standardized clinical examination findings. Participants meeting the predefined criteria for bruxism constituted the bruxism group. Eligible participants without bruxism were selected as controls and matched to the bruxism group according to age and sex. Biochemical laboratory results available from the preceding 6 months were evaluated.

You may qualify if:

• Age 18 years or older. American Society of Anesthesiologists (ASA) physical status I or II. Availability of biochemical laboratory results, including serum vitamin D, parathyroid hormone (PTH), calcium, and albumin, obtained within the previous 6 months.
• Agreement to participate in the study.

You may not qualify if:

• Use of medications affecting vitamin D metabolism. Severe malocclusion. Complete or partial edentulism. Active dental or periodontal pain. History of jaw trauma. History of orthognathic surgery. History of temporomandibular joint (TMJ) surgery. Congenital craniofacial anomalies. Psychiatric disorders. Systemic diseases affecting bone metabolism.

Sponsors & Collaborators

• Ankara Yildirim Beyazıt University: lead

Study Sites (1)

Ankara Yıldırım Beyazıt University

Ankara, 06790, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Bruxism

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Habits; Behavior

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2026
• First Posted: August 25, 2026
• Study Start: May 1, 2023
• Primary Completion: November 1, 2023
• Study Completion: February 1, 2024
• Last Updated: August 25, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)