Trials Sponsors Conditions Drugs Pricing

Conditions

Apical Periodontitis

Keywords

Apical PatencyPostoperative PainRoot Canal TreatmentPeriapical LesionCone-Beam Computed Tomography

Outcome Measures

Primary Outcomes (1)

Postoperative Pain Intensity
Postoperative pain intensity was assessed using a 100-mm visual analog scale (VAS), where 0 mm indicated no pain and 100 mm indicated unbearable pain. Participants recorded the highest pain experienced during each predefined postoperative interval.
8 hours, 24 hours, 3 days, 5 days, and 7 days after root canal treatment

Secondary Outcomes (2)

Number of Participants Who Used Any Postoperative Analgesic Medication
From completion of root canal treatment through Day 7
Baseline Periapical Lesion Volume
Baseline, before root canal treatment

Study Arms (2)

Apical Patency

EXPERIMENTAL

Participants received standardized single-visit root canal treatment. During canal preparation, a #10 stainless-steel K-file was passively advanced approximately 0.5-1 mm beyond the working length after each rotary instrument to maintain apical patency. No intentional apical enlargement or dentin removal was performed.

Procedure: Apical Patency During Root Canal Treatment

No Apical Patency

ACTIVE COMPARATOR

Participants received the same standardized single-visit root canal treatment, but canal preparation was confined to the working length and no instrument was intentionally extended beyond the apical foramen.

Procedure: Root Canal Treatment Without Apical Patency

Interventions

Apical Patency During Root Canal TreatmentProcedure

A #10 stainless-steel K-file was passively advanced approximately 0.5-1 mm beyond the working length after each rotary instrument during standardized single-visit root canal treatment.

Apical Patency

Root Canal Treatment Without Apical PatencyProcedure

Standardized single-visit root canal treatment was performed with instrumentation confined to the working length and without intentional passage of an instrument beyond the apical foramen.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Adult patients.
Systemically healthy and not using regular systemic medications.

Sponsors & Collaborators

Recep Tayyip Erdogan University
Otherlead

Study Sites (1)

Recep Tayyip Erdoğan University Faculty of Dentistry, Department of Endodontics

Rize, Turkey (Türkiye)

MeSH Terms

Conditions

Periapical PeriodontitisPain, Postoperative

Condition Hierarchy (Ancestors)

Periapical DiseasesJaw DiseasesStomatognathic DiseasesPeriodontal DiseasesMouth DiseasesPeriodontitisPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Study Officials

Fatma Pertek Hatipoğlu
Recep Tayyip Erdogan University
PRINCIPAL INVESTIGATOR

Enrollment

113 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NON RANDOMIZED
Masking: NONE
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Associate Professor

Study Record Dates

First Submitted

August 14, 2026

First Posted

August 24, 2026

Study Start

May 22, 2025

Actual (reported)

Apical Patency, Periapical Lesion Volume, and Postoperative Pain After Root Canal Treatment

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (2)

Apical Patency

No Apical Patency

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (2)

Apical Patency

No Apical Patency

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations