NCT07780630

Brief Summary

The biological samples and associated data will facilitate the successful implementation of the research collaboration between Bordeaux University Hospital and the University of Bordeaux on the pathophysiology of bronchopulmonary diseases. In the longer term, this research could lead to the discovery of new therapeutic targets for asthma, chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and acute respiratory distress syndrome.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
650

participants targeted

Target at P75+ for all trials

Timeline
27mo left

Started Sep 2026

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress4%
Sep 2026Dec 2028

First Submitted

Initial submission to the registry

June 12, 2026

Completed
2 months until next milestone

First Posted

Study publicly available on registry

August 21, 2026

Completed
11 days until next milestone

Study Start

First participant enrolled

September 1, 2026

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2028

Last Updated

August 21, 2026

Status Verified

August 1, 2026

Enrollment Period

2.3 years

First QC Date

June 12, 2026

Last Update Submit

August 19, 2026

Conditions

COPD (Chronic Obstructive Pulmonary Disease)Asthma (Diagnosis)Safe Volunteers

Outcome Measures

Primary Outcomes (12)

  • Describe tobacco consumption

    Number pack in years

    At enrollment

  • Describe tobacco statut

    Described as either non-smokers, former smokers or current smokers

    At enrollment

  • Description of demographic status

    Gender (male or female)

    At enrollment

  • Description of demographic status

    Age as years

    At enrollment

  • Description of demographic status

    Body Mass Index (BMI) (kg/m\^2)

    At enrollment

  • Mesure of lung function parameters

    FEV1: forced expiratory volume in 1 sec

    At enrollment

  • Mesure of lung function parameters

    FVC: forced vital capacity

    At enrollment

  • Mesure of lung function parameters

    FEF25-75: forced expiratory flow between 25 and 75% of the FVC

    At enrollment

  • Mesure of lung function parameters

    TLC: total lung capacity

    At enrollment

  • Mesure of lung function parameters

    RV: residual volume

    At enrollment

  • Describe of disease status

    Described as Healthy, COPD or Asthma

    At enrollment

  • Collection type

    Described as bronchial or lung specimens (frozen of embedded in paraffin), bronchial smooth muscle cells, bronchial epithelial cells, alveolar cells, arterial smooth muscle cells, arterial endothelial cells, fibrocytes, mesenchymal cells, lymphocytes, neutrophils, macrophages, organoïds.

    At enrollment

Secondary Outcomes (3)

  • Mesure of blood gas parameter

    At enrollment

  • Mesure of blood gas parameter

    At enrollment

  • Mesure of blood gas parameter

    At enrollment

Study Arms (3)

Patient with COPD

Procedure: Fiberscopic samplesProcedure: SputumProcedure: blood sampling

Patient with Asthma

Procedure: Fiberscopic samplesProcedure: SputumProcedure: Nasal brushingProcedure: blood sampling

Healthy volunteer

Procedure: Fiberscopic samples

Interventions

Fiberscopic samplesPROCEDURE

Perform brushing and/or bronchial biopsies and/or BAL and/or aspiration during bronchial fiberscopy and surgical waste during a lobectomy.

Healthy volunteerPatient with AsthmaPatient with COPD
SputumPROCEDURE

Sputum has been collected for biological analysis.

Patient with AsthmaPatient with COPD
Nasal brushingPROCEDURE

Nasal brushing is a minimally invasive medical procedure used to collect cellular samples from the nasal lining by gently rubbing a small cytology brush against the mucosa.

Patient with Asthma
blood samplingPROCEDURE

Blood sampling is the safe collection of a blood specimen from a vein, finger, or artery to run medical lab tests

Patient with AsthmaPatient with COPD

Eligibility Criteria

Age1 Year - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The population includes male and female participants of all ages (adults and children) who are undergoing or require specific thoracic or bronchial procedures, sputum, nasal brushing, blood as part of clinical care or research. These procedures are conducted under the auspices of Bordeaux University Hospital (e.g., ARISE, BIRDIES, ICEBERG, VIRCHILLD) or Inserm (e.g., COBRA).

You may qualify if:

  • Male or female
  • Adult or children
  • Having required or necessitating, in the context of care or research involving the human person promoted by the Bordeaux University Hospital (ARISE, BIRDIES, ICEBERG, VIRCHILLD) or by Inserm (COBRA), either thoracic surgery such as lobectomy, pneumonectomy or lung transplantation in the Thoracic Surgery Department of the Haut Lévêque Hospital, or bronchial fiberscopy with biopsies and/or bronchial brushing and/or BAL at the children's hospital of the Pellegrin Hospital or at the Haut Lévêque Hospital.
  • Having received or, for children whose holders of parental authority have received, an information note with the possibility of opposition in accordance with the MR004 (French law - Commission Nationale de l'Informatique et des Libertés (CNIL))

You may not qualify if:

  • Patient or holder of parental authority for children who have expressed their opposition to participation in the research

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Bordeaux

Pessac, 33604, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

The origin of the samples is for: * the proximal or distal bronchi of surgical specimens, * pulmonary parenchymas of surgical specimens, * pulmonary arteries of surgical specimens, * bronchial and/or trans-bronchial biopsies of bronchial fiberscopy, * bronchial brushing of bronchial fiberscopy, * bronchoalveolar lavage, sputum, nasal brushing, blood and/or bronchial fiberscopy aspiration.

MeSH Terms

Conditions

Pulmonary Disease, Chronic ObstructiveAsthmaDisease

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsBronchial DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Intervention Hierarchy (Ancestors)

Specimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesSurgical Procedures, OperativeInvestigative Techniques

Central Study Contacts

Patrick BERGER, MD, PhD

CONTACT

+33 5 47 30 27 50patrick.berger@u-bordeaux.fr

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 12, 2026

First Posted

August 21, 2026

Study Start

September 1, 2026

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2028

Last Updated

August 21, 2026

Record last verified: 2026-08

Data Sharing

IPD Sharing
Will share

The data is available from Pr BERGER . An email can be sent to him so that he can contact the data manager and owner, the Bordeaux University Hospital. The data can be made available after contractual agreement.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR
Time Frame
End date

Locations

FR(1)