Prevalence of Fibromyalgia in Patients With Plaque Psoriasis

NCT07773766 | Not Yet Recruiting

• 1 other identifier: Fibromyalgia in Psoriasis
• Study Type: observational
• Target: 110
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational study aims to determine how common fibromyalgia syndrome and central sensitization are in adults with plaque psoriasis compared to healthy individuals. Plaque psoriasis is a chronic inflammatory skin disease that can affect the entire body, which may increase the risk of developing chronic pain conditions. Fibromyalgia causes widespread musculoskeletal pain, fatigue, and sleep disturbances, while central sensitization involves the central nervous system becoming highly sensitive to pain. Researchers will evaluate 55 adult patients diagnosed with plaque psoriasis and 55 age- and sex-matched healthy volunteers at the Dermatology Outpatient Clinic at Assiut University Hospital. Participants will undergo a clinical examination to assess their psoriasis severity and will complete standardized questionnaires to evaluate pain intensity, fibromyalgia symptoms, central sensitization, and overall quality of life. The findings of this study may help doctors better understand these overlapping conditions to improve the early identification and management of pain in patients with psoriasis.

Conditions

Plaque Psoriasis; Fibromyalgia

Keywords

Plaque Psoriasis; Fibromyalgia; Central Sensitization; Quality of Life; Chronic Pain

Outcome Measures

Primary Outcomes (1)

• Percentage of Participants Diagnosed With Fibromyalgia Syndrome

  Fibromyalgia will be diagnosed according to the 2016 American College of Rheumatology (ACR) Diagnostic Criteria. This assessment combines two measures: the Widespread Pain Index (WPI), which assesses pain in 19 body regions with scores ranging from 0 to 19, and the Symptom Severity Scale (SSS), which evaluates fatigue, waking unrefreshed, cognitive symptoms, and other somatic symptoms with scores ranging from 0 to 12. For both scales, higher scores indicate worse symptom severity. The combined scores are used to establish a diagnosis of fibromyalgia.

  Baseline

Study Arms (2)

Patients with Plaque Psoriasis

Adult male and female patients (18 years of age and older) who have been clinically diagnosed with plaque psoriasis.

Healthy Controls

Apparently healthy, age- and sex-matched volunteers with no history of psoriasis, psoriatic arthritis, or other chronic inflammatory or rheumatic diseases.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult male and female patients (18 years of age and older) clinically diagnosed with plaque psoriasis who are attending the Dermatology Outpatient Clinic at Assiut University Hospital. It also includes a control group of apparently healthy, age- and sex-matched volunteers.

You may qualify if:

• Adult patients (≥18 years) with clinically diagnosed plaque psoriasis.
• Both males and females.
• Willing to participate and provide written informed consent.
• For controls: Apparently healthy age- and sex-matched volunteers.
• For controls: No history of psoriasis, psoriatic arthritis, or other chronic inflammatory or rheumatic diseases.
• For controls: Willing to participate and provide written informed consent.

You may not qualify if:

• Patients with psoriatic arthritis or other inflammatory arthritis.
• Patients with other diagnosed rheumatic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis).
• Patients with previously diagnosed major depressive disorder or generalized anxiety disorder.
• Patients with uncontrolled diabetes mellitus, heart failure, renal failure, or thyroid disorders.
• Current use of antidepressants, anticonvulsants, or benzodiazepines.
• History of malignancy.
• Pregnancy.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Fibromyalgia; Chronic Pain

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Family Medicine

Study Record Dates

• First Submitted: August 14, 2026
• First Posted: August 19, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: August 19, 2026

Record last verified: 2026-08