Comparative Efficacy of Oil Pulling and Chlorhexidine on Plaque Induced Gingivitis

NCT07769112 | Completed

• 2 other identifiers: irb/D-000111/25LCMD
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized clinical trial aims to compare the efficacy of chlorhexidine and coconut oil in plaque-induced gingivitis patients. The study seeks to determine whether coconut oil pulling can provide comparable anti-plaque and anti-inflammatory effects to chlorhexidine mouthwash while producing fewer side effects. A total of 80 participants who diagnosed as plaque induced gingivitis will be randomly allocated into two equal groups (coconut and chlorhexidine). Clinical parameters, including Plaque Index and Gingival Index, will be assessed at baseline, day 7, day 14, and day 21 to evaluate changes in plaque and gingival inflammation following the interventions.

Conditions

Plaque Induced Gingivitis

Keywords

gingivitis, chlorhexidine, coconut oil, dental plaque , oral hygiene, periodontal diseases

Outcome Measures

Primary Outcomes (1)

• Reduction in Gingival Inflammation

  To assess the gingival inflammation using Gingival Index scores in participants receiving chlorhexidine mouthwash and coconut oil pulling therapy

  Baseline, Day 7, Day 14, and Day 21

Secondary Outcomes (1)

• Reduction in Dental Plaque

  Baseline, Day 7, Day 14, and Day 21

Study Arms (2)

chlorhexidine mouthwash group

EXPERIMENTAL

Participants will use 0.12% chlorhexidine mouthwash twice daily for 21 days.

Other: Chlorhexidine mouthwash (0.12%)

coconut oil pulling group

EXPERIMENTAL

Participants will rinse with coconut oil once daily for 10-15 minutes for 21 days.

Other: coconut oil pulling

Interventions

Chlorhexidine mouthwash (0.12%) OTHER

Participants will use 0.12% chlorhexidine mouthwash twice daily for 21 days.

chlorhexidine mouthwash group

coconut oil pulling OTHER

Participants will rinse with coconut oil once daily for 10-15 minutes for 21 days.

coconut oil pulling group

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Individual aged between 22-60years.
• Individual who have retained 28 no of teeth in the mouth.
• Individuals who have diagnosed as plaque induced gingivitis along with mild to moderate gingival inflammation.

You may not qualify if:

• Individual who have any systemic medical illness
• Multiple extractions, overhang restoration, wearing any appliance
• Periodontal problem with pocket depth more than 3mm
• Current or recent history of antibiotic consumption
• Non compliance that is unable to maintain their hygiene -

Sponsors & Collaborators

• Liaquat College of Medicine and Dentistry: lead

Study Sites (1)

Dr. Nida Tariq

Karachi, Sindh, 75330, Pakistan

Location

MeSH Terms

Conditions

Gingivitis; Dental Plaque; Periodontal Diseases

Condition Hierarchy (Ancestors)

Infections; Gingival Diseases; Mouth Diseases; Stomatognathic Diseases; Dental Deposits; Tooth Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Group A: CONTROL GROUP Participants will receive a 420ml(10 x42) ml opaque plastic bottle containing 0.12% chlorhexidine (CHX). They will be instructed to rinse 30sec with 10ml of the solution after brushing twice daily (morning after toothbrush and at night after tooth brush) for 3 weeks . Group B: TEST GROUP Participants will receive a 210 ml(10x21) ml opaque plastic bottle with a solution for cold pressed 100% original coconut oil pulling. They will be advised to rinse with two teaspoons(5ml each) until their mouth is half-filled, then swish the oil left to right and front to back until it turns milky white and thin before spitting it out. This procedure will be done on an empty stomach in the morning for 3 weeks.

Study Record Dates

• First Submitted: April 4, 2026
• First Posted: August 17, 2026
• Study Start: August 12, 2024
• Primary Completion: February 23, 2025
• Study Completion: July 12, 2025
• Last Updated: August 17, 2026

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)