Effects of Turkish Coffee and Green Tea in Fatty Liver Disease

NCT07768956 | Completed

• 1 other identifier: OKANU-NAFLD-2026-001
• Study Type: interventional
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

Non-alcoholic fatty liver disease (NAFLD) is a common liver condition associated with metabolic disorders and lifestyle factors. This study aims to evaluate the effects of Turkish coffee and green tea consumption in addition to a Mediterranean diet intervention on liver fat content, biochemical parameters, and anthropometric measurements in individuals with fatty liver disease. Participants received a 12-week Mediterranean diet program and were assigned to groups consuming Turkish coffee, green tea, or no additional beverage intervention. Changes in liver ultrasonography findings, liver enzymes, metabolic parameters, and body measurements were evaluated before and after the intervention.

Conditions

Non Alcoholic Fatty Liver Disease

Keywords

non-alcoholic fatty liver disease, Turkish coffee, green tea, diet therapy

Outcome Measures

Primary Outcomes (1)

• Change in liver steatozis grade by abdominal Ultrasonography

  Liver steatosis was assessed by abdominal ultrasonography and graded as Grade 0 (no steatosis), Grade 1 (mild steatosis), Grade 2 (moderate steatosis), and Grade 3 (severe steatosis). Higher grades indicate greater severity of hepatic steatosis.

  Baseline and 12 weeks

Secondary Outcomes (3)

• Change in Alanine Aminotransferase (ALT) Level (U/L)

  Baseline and 12 Weeks

• Change in Aspartate Aminotransferase (AST) Level (U/L)

  Baseline and Week 12

• Change in Gamma-Glutamyl Transferase (GGT) Level (U/L)

  Baseline and Week 12

Other Outcomes (9)

• Change in Body Weight (kg)

  Baseline and Week 12

• Change in Body Mass Index (BMI) (kg/m²)

  Baseline and Week 12

• Change in Waist Circumference (cm)

  Baseline and Week 12

Study Arms (3)

Mediterranean Diet + Green Tea

EXPERIMENTAL

Participants received a Mediterranean diet intervention and consumed green tea three times daily as an adjunct to the diet for 12 weeks.

Behavioral: green tea; Behavioral: mediterranean diet

Mediterranean Diet + Turkish Coffee

EXPERIMENTAL

Participants received a Mediterranean diet intervention and consumed Turkish coffee twice daily for 12 weeks

Behavioral: Turkish Coffee; Behavioral: mediterranean diet

Mediterranean Diet Control

ACTIVE COMPARATOR

Participants received a Mediterranean diet intervention without additional Turkish coffee or green tea consumption for 12 weeks.

Behavioral: mediterranean diet

Interventions

green tea BEHAVIORAL

Participants consumed green tea three times daily as an adjunct to a Mediterranean diet intervention for 12 weeks.

Mediterranean Diet + Green Tea

Turkish Coffee BEHAVIORAL

Participants consumed Turkish coffee twice daily as an adjunct to a Mediterranean diet intervention for 12 weeks.

Mediterranean Diet + Turkish Coffee

mediterranean diet BEHAVIORAL

participants received a Mediterranean diet intervention without additional Turkish coffee or green tea consumption for 12 weeks.

Mediterranean Diet + Green Tea; Mediterranean Diet + Turkish Coffee; Mediterranean Diet Control

Eligibility Criteria

• Age: 19 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants aged 19-65 years with a diagnosis of non-alcoholic fatty liver disease (NAFLD).
• Not using medications for diabetes, dyslipidemia, or rheumatoid arthritis.
• Not using dietary supplements.
• No dietary program followed within the previous month.
• No severe psychiatric disorders.
• Willingness to participate in the study and provide informed consent.

You may not qualify if:

• Presence of diabetes, dyslipidemia, or rheumatoid arthritis.
• Alcohol consumption.
• Positive hepatitis B surface antigen (HBsAg), hepatitis C positivity, autoimmune hepatitis, liver cirrhosis, toxic hepatitis, or alanine aminotransferase (ALT) levels ≥10 times the upper limit of normal.
• Presence of liver malignancy or hepatic decompensation.
• Use of systemic corticosteroids or methotrexate within the previous 6 months.
• Pregnancy or lactation.
• Regular use of dietary supplements.
• Following a dietary program within the previous month.
• Presence of severe psychiatric disorders.
• High daily consumption of tea and coffee.

Sponsors & Collaborators

• Okan University: lead

Study Sites (1)

Istanbul Dr. Lutfi Kirdar City Hospital

Istanbul, Istanbul, 34865, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Non-alcoholic Fatty Liver Disease

Interventions

Tea; Diet, Mediterranean

Condition Hierarchy (Ancestors)

Fatty Liver; Liver Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Plant Preparations; Biological Products; Complex Mixtures; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Diet, Plant-Based; Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena

Study Officials

• Hande Öngün Yılmaz, PhD

  BANDIRMA ONYEDI EYLUL UNIVERSITY, BANDIRMA VOCATIONAL SCHOOL

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This is a 12-week, three-arm, parallel-group randomized controlled study. Participants were assigned to one of three groups: Turkish coffee group, green tea group, or control group. All participants received a Mediterranean diet intervention. In addition, the Turkish coffee group consumed Turkish coffee twice daily, and the green tea group consumed green tea three times daily. The control group received the Mediterranean diet intervention without additional beverage supplementation.

Study Record Dates

• First Submitted: August 4, 2026
• First Posted: August 17, 2026
• Study Start: September 25, 2024
• Primary Completion: August 15, 2025
• Study Completion: August 15, 2025
• Last Updated: August 17, 2026

Record last verified: 2026-07

Locations

TU (1)