NCT07765225|Completed
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Sponsor study identifier
interventional
124
1 country
1
Study Start
February 1, 2020
Actual (reported)Primary Completion
March 1, 2026
Actual (reported)Study Completion
May 1, 2026
Actual (reported)This prospective, non-randomized, controlled study evaluated the efficacy of a topical cosmetic keratolytic preparation (serum and cream containing urea, salicylic acid, and collagen) in reducing the thickness and associated pain of hyperkeratotic foot lesions (calluses and corns). High-frequency ultrasonography (18 MHz) was used for precise, quantitative measurement of lesion thickness before and after a two-month intervention. Participants were allocated to four parallel groups (treated calluses, untreated callus controls, treated corns, and untreated corn controls).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 1, 2026
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 1, 2020
Actual (reported)March 1, 2026
Actual (reported)May 1, 2026
Actual (reported)August 10, 2026
Actual (reported)August 14, 2026
Actual (reported)Change in Hyperkeratotic Lesion Thickness
Lesion thickness measured in centimetres using high-frequency ultrasonography (Esaote MyLab60 with an 18 MHz linear probe)
Baseline and 2 months
Change in Lesion-Associated Pain
Baseline and 2 months
Women with foot calluses applying the topical keratolytic cosmetic serum and cream twice daily for 2 months.
Women with foot calluses receiving no topical treatment over the 2-month observation period
Women with foot corns applying the topical keratolytic cosmetic serum and cream twice daily for 2 months
Application of 2 mL serum followed by 2 mL cream containing urea, salicylic acid, and collagen, massaged into the hyperkeratotic lesion for 2 minutes, twice daily (morning and evening) for 2 months
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
OSTEON Clinic
Swidnica, Poland
1. Wortsman, X. Expanding dermatologic ultrasonography applications: further insights for enhanced patient management. Ultrasonography 42 (3), 476-477. https://doi.org/10.14366/usg.23082 (2023). 2. Bader, D. & Worsley, P. Technologies to monitor the health of loaded skin tissues. Biomed. Eng. Online 17 (1), 40-59. https://doi.org/10.1186/s12938-018-0457 (2018). 3. Benedetti, J. Diagnostic tests for skin disorders. MSD Manual Professional Edition (2024). 4. National Institute of Biomedical Imaging and Bioengineering. Ultrasound. NIBIB (Bethesda, MD). 5. Bhatta, A. et al. Application of high-frequency ultrasound in dermatology. Discov. Med. 26 (145), 237-242 (2018). 6. Cheng, X. et al. High-frequency ultrasound in blistering skin diseases: a useful method for differentiating blister locations. J. Ultrasound Med. 36 (11), 2367-2371. https://doi.org/10.1002/jum.14302 (2017). 7. Cohen, P. R. & Anderson, C. A. Topical selenium sulfide for the treatment of hyperkeratosis. Dermatol. Ther. (Heidelb.) 8 (4), 639-646. https://doi.org/10.1007/s13555-018-0247-2 (2018). 8. Wortsman, X. Top applications of dermatologic ultrasonography that can modify management. Ultrasonography 42, 183-202. https://doi.org/10.14366/usg.22130 (2023). 9. Argalia, G. et al. High-frequency and ultra-high-frequency ultrasound in dermatologic diseases and aesthetic medicine. Medicina (Kaunas) 61 (2), 220. https://doi.org/10.3390/medicina61020220 (2025). 10. Cisoń, H. & Białynicki-Birula, R. High-frequency ultrasonography: one of the modern imaging diagnostic methods in dermatology. Authors' own experience and review. Adv. Dermatol. Allergol. 41 (3), 306-313. https://doi.org/10.5114/ada.2024.141108 (2024). 11. Wang, Q. et al. Role of high-frequency ultrasound in differentiating benign and malignant skin lesions: potential and limitations. Ultrasonography 43 (4), 238-249. https://doi.org/10.14366/usg.24015 (2024). 12. Jaguś, D., Malinowska, S. & Mlosek, R. Skin ultrasound diagnostics in beauty parlour. Ae
124 participants (actual enrollment reported by the registry).
First Submitted
August 10, 2026
First Posted
August 14, 2026
Study Start
February 1, 2020
Actual (reported)Women with foot corns receiving no topical treatment over the 2-month observation period
Contact the study team to confirm eligibility.
Primary Completion
March 1, 2026
Actual (reported)Study Completion
May 1, 2026
Actual (reported)Last Updated
August 14, 2026
Record last verified: 2026-08
De-identified individual participant data (lesion thickness measurements and VAS pain scores, before and after the intervention) underlying the results reported in the associated publication will be made available.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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