PK_treatment
A Study of Efficacy of Chlorhexidine Scrub, ZnO Nanoparticles Socks and the Combination of Chlorhexidine Scrub and ZnO Nanoparticles Socks for Treatment of Pitted Keratolysis
Sponsor study identifier
interventional
60
1 country
1
Study Start
March 15, 2022
Actual (reported)Primary Completion
November 1, 2022
Actual (reported)Study Completion
November 1, 2022
Actual (reported)This study aimed to study the efficacy of chlorhexidine scrub, zinc oxide nanoparticles (ZnO-NPs) socks and the combination of chlorhexidine scrub and ZnO-NPs socks in treatment of pitted keratolysis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 1, 2022
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1, 2020
Actual (reported)April 3, 2020
Actual (reported)March 15, 2022
Actual (reported)November 1, 2022
Actual (reported)November 1, 2022
Actual (reported)The number of patients who had improvement of pitted lesion after treatment
Effectiveness was evaluated
4 weeks
The percentage of patients developed any side effect such as erythema, burning
4 weeks
Chorhexidine scrub was given to patients for 4 weeks
ZnO-NPs socks to patients for 4 weeks
Chorhexidine scrub and ZnO-NPs socks to patients for 4 weeks
Chorhexidine scrub was given to patients for 4 weeks
ZnO-NPs socks was given to patients for 4 weeks
Department of Dermatology Siriraj Hospital
Bangkok, 10700, Thailand
de Almeida HL Jr, Siqueira RN, Meireles Rda S, Rampon G, de Castro LA, Silva RM. Pitted keratolysis. An Bras Dermatol. 2016 Jan-Feb;91(1):106-8. doi: 10.1590/abd1806-4841.20164096.
Makhecha M, Dass S, Singh T, Gandhi R, Yadav T, Rathod D. Pitted keratolysis - a study of various clinical manifestations. Int J Dermatol. 2017 Nov;56(11):1154-1160. doi: 10.1111/ijd.13744. Epub 2017 Sep 18.
van der Snoek EM, Ekkelenkamp MB, Suykerbuyk JC. Pitted keratolysis; physicians' treatment and their perceptions in Dutch army personnel. J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1120-6. doi: 10.1111/j.1468-3083.2012.04674.x. Epub 2012 Aug 7.
Sumanas Bunyaratavej, MD
Mahidol University
60 participants (actual enrollment reported by the registry).
First Submitted
April 1, 2020
First Posted
April 3, 2020
Study Start
March 15, 2022
Actual (reported)Combination of chorhexidine scrub and ZnO-NPs socks was given to patients for 4 weeks
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Leeyaphan C, Bunyaratavej S, Taychakhoonavudh S, Kulthanachairojana N, Pattanaprichakul P, Chanyachailert P, Ongsri P, Arunkajohnsak S, Limphoka P, Kulthanan K. Cost-effectiveness analysis and safety of erythromycin 4% gel and 4% chlorhexidine scrub for pitted keratolysis treatment. J Dermatolog Treat. 2019 Sep;30(6):627-629. doi: 10.1080/09546634.2018.1543846. Epub 2018 Dec 11.
Vlahovic TC, Dunn SP, Kemp K. The use of a clindamycin 1%-benzoyl peroxide 5% topical gel in the treatment of pitted keratolysis: a novel therapy. Adv Skin Wound Care. 2009 Dec;22(12):564-6. doi: 10.1097/01.ASW.0000363468.18117.fe. No abstract available.
Bunyaratavej S, Leeyaphan C, Chanyachailert P, Pattanaprichakul P, Ongsri P, Kulthanan K. Clinical manifestations, risk factors and quality of life in patients with pitted keratolysis: a cross-sectional study in cadets. Br J Dermatol. 2018 Nov;179(5):1220-1221. doi: 10.1111/bjd.16923. Epub 2018 Sep 14. No abstract available.
Primary Completion
November 1, 2022
Actual (reported)Study Completion
November 1, 2022
Actual (reported)Last Updated
May 25, 2023
Record last verified: 2023-05
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Source: ClinicalTrials.gov.
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