Pericapsular Nerve Group (PENG) Block on Postoperative Pain Management After Acetabular Fracture Fixation

NCT07765095 | Recruiting

• 1 other identifier: 2406241594
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to find out whether a Pericapsular Nerve Group (PENG) block, a type of nerve block used to control pain, can reduce pain after surgery in adults with an acetabular (hip socket) fracture who are undergoing surgical repair. The study will also evaluate the safety of the PENG block. The main questions this study aims to answer are: Does a PENG block reduce pain after surgery? Does a PENG block reduce the need for opioid pain medications after surgery? Are there any side effects or complications related to the PENG block? Researchers will compare patients who receive a PENG block with patients who do not receive a PENG block to determine whether the block improves pain control after surgery. Participants will: Be randomly assigned to receive either a PENG block or no PENG block before surgery while under general anesthesia. Undergo surgery to repair their acetabular fracture. Receive the same standard pain medications after surgery. Be asked to rate their pain at several time points after surgery using a standard pain scale. Have their use of pain medications, recovery, and any side effects recorded during their hospital stay and follow-up.

Conditions

Acetabular Fractures

Keywords

Acetabular Fractures; Pain Management; Pericapsular Nerve Group (PENG); Open Reduction and Internal Fixation (ORIF); Regional Block

Outcome Measures

Primary Outcomes (1)

• Numeric Pain Rating Scale (NPRS)

  The NPRS is an 11-point scale scored from 0-10, with " 0 " representing no pain and "10" being the most intense pain experienced. Patients verbally select a value that is most in line with the intensity of pain that they have experienced at each time point under evaluation.

  From surgery to 48 hours after surgery (12 hour Intervals)

Secondary Outcomes (3)

• Morphine Miligram Equivalent (MME)

  From surgery to 48 hours after surgery (12 hour Intervals)

• Time to first opioid dose

  From surgery to 48 hours after surgery (Will quantify from surgery to time of administration)

• Postoperative Complications

  From surgery to 48 hours after surgery

Study Arms (2)

PENG Block Group

EXPERIMENTAL

This group includes participants who will receive the pericapsular nerve group (PENG) block after surgical intervention.

Procedure: Pericapsular nerve group (PENG) block

NO PENG Block Group

NO INTERVENTION

This group includes participants who will not receive the pericapsular nerve group (PENG) block after surgical intervention and will be considered our control group.

Interventions

Pericapsular nerve group (PENG) block PROCEDURE

PENG Block is a regional block technique well documented in the literature for certain orthopedic injuries and interventions. However, the efficacy of this intervention on acetabular fracture fixation has not been well studied or addressed in previous literature.

PENG Block Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient age 18 years or older
• Acetabular Fracture amenable to surgery through the Kocher-Langenbeck approach
• Full weight-bearing capacity prior to the trauma
• Providing written informed consent

You may not qualify if:

• Age less than 18 years old
• Fracture pattern not amenable to surgery through Kocher-Langenbeck approach
• Lower extremity fracture ipsilateral to the acetabular fracture
• Any traumatic injury that requires surgical management by other surgical specialty
• Bilateral Acetabular Fractures
• Limited weight bearing capacity prior to the trauma
• Procedure performed under any anesthesia other than GETA
• Chronic opioid use
• History of Substance Abuse
• Allergies or history of adverse reactions to any of the drugs used in the
• Mental Disability
• History of Psychiatric disorders

Sponsors & Collaborators

• University of Puerto Rico: lead

Study Sites (1)

Puerto Rico Medical Center

San Juan, 00935, Puerto Rico

RECRUITING

MeSH Terms

Conditions

Agnosia

Interventions

Dental Occlusion

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dentistry; Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Officials

• Luis Lojo Sojo, MD

  University of Puerto Rico

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Prospective Doble-Blinded Randomized Controlled Trial

Study Record Dates

• First Submitted: August 6, 2026
• First Posted: August 14, 2026
• Study Start: September 8, 2025
• Primary Completion (Estimated): January 30, 2027
• Study Completion (Estimated): March 30, 2027
• Last Updated: August 14, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share

Locations

PR (1)