Sarcopenia in Acute Ischemic Stroke

NCT07764172 | Recruiting

• 1 other identifier: ACUTE-SARC-MC-2026
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this observational study is to determine the prevalence of sarcopenia in patients aged 50 years and older with acute ischemic stroke, to characterize its trajectory during the acute phase using instrumental verification and functional-cognitive assessments, and to evaluate its impact on functional outcome at three months. The main research question is: Is the presence of sarcopenia at admission associated with less favorable stroke outcomes, including higher rates of complications and mortality? Participants receiving standard medical care for acute ischemic stroke will undergo extended functional assessment for sarcopenia, and a subset will additionally undergo cognitive evaluation.

Conditions

Sarcopenia; Acute Stroke

Keywords

sarcopenia; acute stroke

Outcome Measures

Primary Outcomes (2)

• Change from Baseline in Barthel Index for Activities of Daily Living at 14 days

  Lower scores indicate increasing disability and a greater need for skilled care. Min - 0 ( \< 20 - totally dependent), max - 100 ( \> 80 - independent).

  Baseline and 14 days

• Change from Baseline in Modified Rankin scale at 90 days

  Min - 0 (no disability), max - 6 (dead). A score of 0 is no disability, 5 is disability requiring constant care for all needs; 6 is death.

  Baseline and 90 days

Secondary Outcomes (11)

• Number of Participants with sarcopenia

  Baseline

• Change from Baseline in arm muscle mass at 14 and 28 days.

  Baseline, 14 and 28 days

• Change from Baseline in calf circumference at 14 and 28 days

  Baseline, 14 and 28 days

• Change from Baseline in handgrip strength at 14 and 28 days.

  Baseline, 14 and 28 days.

• Correlations between anthropometric measures and ultrasound/CT parameters

  Baseline, 14, 28, and 90 days

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population comprises patients with acute ischemic stroke admitted within the first 72 hours after symptom onset.

You may qualify if:

• Age 50 years and older
• Acute ischemic stroke confirmed by CT or MRI
• Admission within the first 72 hours
• Written informed consent and availability of a contact telephone number for follow-up

You may not qualify if:

• TIA without a visible lesion on neuroimaging; bilateral hemiparesis
• Amputations or severe contractures that preclude anthropometric assessment
• Active cancer at stage IV or life expectancy of less than 3 months
• Neuromuscular diseases; chronic use of systemic glucocorticoids for more than 3 months
• Pregnancy; refusal to participate
• Discontinuation criteria (drop-out)
• Discharge or death within the first 7 days
• Withdrawal of consent
• Transfer to another facility resulting in loss of contact

Sponsors & Collaborators

• University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba): lead

Study Sites (1)

Moscow State Budgetary Healthcare Institution "Moscow City Hospital named after S.S. Yudin, Moscow Healthcare Department"

Moscow, 115446, Russia

RECRUITING

MeSH Terms

Conditions

Sarcopenia; Stroke

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 4, 2026
• First Posted: August 13, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: August 13, 2026

Record last verified: 2026-07

Locations

RU (1)